IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
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출원번호 |
US-0609538
(2009-10-30)
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등록번호 |
US-8521245
(2013-08-27)
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발명자
/ 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 |
피인용 횟수 :
0 인용 특허 :
77 |
초록
▼
A method and apparatus for controlling delivery of therapy that includes an emitting portion emitting light at a predetermined emitted light intensity to a volume of tissue at a plurality of wavelengths, and a detecting portion detecting the emitted light scattered by the volume of tissue to generat
A method and apparatus for controlling delivery of therapy that includes an emitting portion emitting light at a predetermined emitted light intensity to a volume of tissue at a plurality of wavelengths, and a detecting portion detecting the emitted light scattered by the volume of tissue to generate corresponding detected light intensity output signals. A control module adjusts the detected light intensity output signals for shifts in intensity corresponding to the emitted light intensity, and determines a tissue oxygenation index in response to only the adjusted detected light intensity output signals, and a therapy delivery module controlling therapy in response to the determined tissue oxygenation index.
대표청구항
▼
1. A method of delivering therapy in a medical device, comprising: emitting light from an emitting portion of a sensor at a predetermined emitted light intensity to an adjacent volume of tissue at a plurality of wavelengths;detecting the emitted light scattered by the volume of tissue to generate co
1. A method of delivering therapy in a medical device, comprising: emitting light from an emitting portion of a sensor at a predetermined emitted light intensity to an adjacent volume of tissue at a plurality of wavelengths;detecting the emitted light scattered by the volume of tissue to generate corresponding detected light intensity output signals;detecting, in the emitting portion of the sensor, a change corresponding to a shift in the emitted light intensity from the predetermined intensity before the emitted light enters the adjacent tissue volume;adjusting the detected light intensity output signals in response to the detected change;determining a tissue oxygenation index in response to only the adjusted detected light intensity output signals; andcontrolling delivery of a therapy in response to the determined tissue oxygenation index. 2. The method of claim 1, further comprising: generating an emitted light reference signal from a reference light detector in the emitting portion configured to detect the emitted light before it enters the adjacent tissue volume; andadjusting drive signals associated with the light emission in response to the generated emitted light reference signal. 3. The method of claim 1, wherein the wavelengths of the plurality of wavelengths are equally spaced. 4. The method of claim 1, wherein determining a tissue oxygenation index comprises: determining an attenuation measurement for each wavelength of the plurality of wavelengths in response to the detected light intensity output signals;determining a second derivative of the attenuation measurement for a first wavelength and a second wavelength of the plurality of wavelengths in response to only the adjusted detected light intensity output signals; anddetermining the tissue oxygenation index in response to the determined second derivative. 5. The method of claim 4, wherein determining a tissue oxygenation index further comprises: determining a scaled second derivative of the attenuation measurement of the first wavelength using the determined second derivative of the attenuation of the second wavelength of the predetermined wavelengths; anddetermining the tissue oxygenation index in response to the determined scaled second derivative. 6. The method of claim 5, further comprising determining at least one of an oxygen saturation index and a hemoglobin volume fraction in response to one of the second derivative and the scaled second derivative, wherein the tissue oxygenation index is determined in response to at least one of the oxygen saturation index and the hemoglobin volume fraction. 7. The method of claim 1, wherein adjusting the detected light intensity output signals comprises: generating an emitted light reference signal from a reference light detector in the emitting portion configured to detect the emitted light before it enters the adjacent tissue volume;determining a correction term in response to the generated reference signal; andadjusting the detected light intensity output signals in response to the correction term. 8. The method of claim 1, wherein detecting, in the emitting portion of the sensor, a change corresponding to a shift in the emitted light intensity comprises controlling a drive signal applied to a light source; wherein adjusting the detected light intensity output signal comprises adjusting a calibration constant in response to a change in the drive signal. 9. A medical device having a sensor for controlling delivery of therapy by the device, comprising: an emitting portion configured to emit light at a predetermined emitted light intensity to an adjacent volume of tissue at a plurality of wavelengths;a detecting portion configured to detect the emitted light scattered by the volume of tissue to generate corresponding detected light intensity output signals;a control module configured to: detect, in the emitting portion of the sensor, a change corresponding to a shift in the emitted light intensity from the predetermined intensity before the emitted light enters the adjacent tissue volume;adjust the detected light intensity output signals in response to the detected change, anddetermine a tissue oxygenation index in response to only the adjusted detected light intensity output signals; anda therapy delivery module configured to control delivery of a therapy in response to the determined tissue oxygenation index. 10. The device of claim 9, further comprising a reference light detector in the emitting portion for detecting the emitted light before it enters the adjacent tissue volume and generating an emitted light reference signal, wherein the control module adjusts drive signals associated with the light emission in response to the generated emitted light reference signal. 11. The device of claim 9, wherein the wavelengths of the plurality of wavelengths are equally spaced. 12. The device of claim 9, wherein the control module is configured to determine an attenuation measurement for each wavelength of the plurality of wavelengths in response to the detected light intensity output signals, determine a second derivative of the attenuation measurement for a first wavelength and a second wavelength of the plurality of wavelengths in response to only the detected light intensity output signals, and determine the tissue oxygenation index in response to the determined second derivative. 13. The device of claim 12, wherein the control module is configured to determine a scaled second derivative of the attenuation measurement of the first wavelength using the determined second derivative of the attenuation of a second wavelength, and determine the first tissue oxygenation index in response to the determined scaled second derivative. 14. The device of claim 13, wherein the control module is configured to determine at least one of an oxygen saturation index and a hemoglobin volume fraction in response to one of the second derivative and the scaled second derivative, and determine the tissue oxygenation index in response to at least one of the oxygen saturation index and the hemoglobin volume fraction. 15. The device of claim 9, further comprising a reference detector for detecting the emitted light before it enters the adjacent tissue volume to generate an emitted light reference signal, wherein the control module is configured to determine a correction term in response to the generated reference signal and adjust the detected light intensity output signals in response to the correction term. 16. A non-transitory computer readable medium having computer executable instructions for performing a method comprising: emitting light from an emitting portion of a sensor at a predetermined emitted light intensity to an adjacent volume of tissue at a plurality of wavelengths;detecting the emitted light scattered by the volume of tissue to generate corresponding detected light intensity output signals;detecting, in the emitting portion of the sensor, a change corresponding to a shift in the emitted light intensity from the predetermined intensity before the emitted light enters the adjacent tissue volume;adjusting the detected light intensity output signals in response to the detected change;determining a tissue oxygenation index in response to only the adjusted detected light intensity output signals; andcontrolling delivery of a therapy in response to the determined tissue oxygenation index. 17. The computer readable medium of claim 16, the method further comprising: generating an emitted light reference signal from a reference light detector in the emitting portion configured to detect the emitted light before it enters the adjacent tissue volume; andadjusting drive signals associated with the light emission in response to the generated emitted light reference signal. 18. The computer readable medium of claim 16, wherein the wavelengths of the plurality of wavelengths are equally spaced. 19. The computer readable medium of claim 16, wherein determining a tissue oxygenation index comprises: determining an attenuation measurement for each wavelength of the plurality of wavelengths in response to the detected light intensity output signal;determining a second derivative of the attenuation measurement for a first wavelength and a second wavelength of the plurality of wavelengths in response to only the detected light intensity output signals; anddetermining the tissue oxygenation index in response to the determined second derivative. 20. The computer readable medium of claim 19, wherein determining a tissue oxygenation index comprises: determining a scaled second derivative of the attenuation measurement of the first wavelength using the determined second derivative of the attenuation of the second wavelength of the predetermined wavelengths; anddetermining the tissue oxygenation index in response to the determined scaled second derivative. 21. The computer readable medium of claim 20, the method further comprising determining at least one of an oxygen saturation index and a hemoglobin volume fraction in response to one of the second derivative and the scaled second derivative, wherein the tissue oxygenation index is determined in response to at least one of the oxygen saturation index and the hemoglobin volume fraction. 22. The computer readable medium of claim 16, wherein adjusting the detected light intensity output signal comprises: generating an emitted light reference signal from a reference light detector in the emitting portion configured to detect the emitted light before it enters the adjacent tissue volume;determining a correction term in response to the generated reference signal; andadjusting the detected light intensity output signals in response to the correction term.
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