Apparatus and methods are provided for thermally and/or mechanically treating tissue, such as valvular structures, to reconfigure or shrink the tissue in a controlled manner. Mechanical clips are implanted over the leaflets of a valve, e.g., in the heart, either alone or after thermal treatment to c
Apparatus and methods are provided for thermally and/or mechanically treating tissue, such as valvular structures, to reconfigure or shrink the tissue in a controlled manner. Mechanical clips are implanted over the leaflets of a valve, e.g., in the heart, either alone or after thermal treatment to cause the valve to close more tightly. The clips are delivered by a catheter and may be configured to traverse directly over the valve itself or to lie partially over the periphery of the valve to prevent obstruction of the valve channel. The clips can be coated with drugs or a radiopaque coating. Alternatively, individual anchors with a tensioning element, like a suture, may be used to approximate the valves towards each other. The catheter can also incorporate sensors or energy delivery devices, e.g., transducers, on its distal end.
대표청구항▼
1. A method of reducing a diameter of a mitral valve of a heart to reduce regurgitation of blood across the mitral valve, the method comprising: providing a plurality of anchors coupleable to a tensioning element;advancing a catheter into a left ventricle of the heard and delivering the plurality of
1. A method of reducing a diameter of a mitral valve of a heart to reduce regurgitation of blood across the mitral valve, the method comprising: providing a plurality of anchors coupleable to a tensioning element;advancing a catheter into a left ventricle of the heard and delivering the plurality of anchors through the catheter;deploying a plurality of anchors into heart tissue around the periphery of the mitral valve where the plurality of anchors are connectable to the tensioning element;cinching the tensioning element once connected to the plurality of anchors to approximate opposing sides of the mitral valve to draw or close the opening of the valve;securing the tensioning element to maintain tension across the tensioning element and plurality of anchors; andremoving the catheter from the left ventricle. 2. The method of claim 1, where the tensioning element is sequentially coupled to each anchor. 3. The method of claim 1, where deploying, the plurality of anchors into heart tissue comprises deploying the plurality of anchors with the tensioning element pre-threaded through the anchors. 4. The method of claim 1, where deploying the plurality of anchors into heart tissue further comprises threading the tensioning element with the anchors after the anchors are positioned in tissue. 5. The method of claim 1, where securing the tensioning element to maintain tension comprises affixing a fastener to the tensioning element. 6. The method of claim 1, where the tensioning element comprises a suture or wire. 7. The method of claim 1, where advancing the catheter into the left ventrical comprises advancing the catheter through the vasculature. 8. The method of claim 1, where deploying the plurality of anchor comprises sequentially advancing each of the anchor from the catheter into heart tissue. 9. An assembly for reducing a diameter of a mitral valve of a heart to reduce regurgitation of blood across the mitral valve, the assembly comprising: a plurality of anchors configured to be implanted within muscle around a perimeter of the mitral valve through a catheter;a tensioning member sequentially connectible to each anchor, the tensioning member having sufficient strength for cinching the tensioning element once sequentially connected to the plurality of anchors to approximate opposing sides of the mitral valve to draw or close the opening of the valve; anda catheter containing the plurality of anchors and the tensioning element, where the catheter is sufficiently flexible to navigate through the vasculature and into a left atrium. 10. The assembly of claim 9, where the distal end of each of the anchors is barbed. 11. The assembly of claim 9, where the proximal end of each of the anchors is indented. 12. The assembly of claim 9, where the anchors each define at least one notch along a length of the member adjacent to the opening. 13. The assembly of claim 9, where the anchor embers each define a sharpened edge at least partially around the opening. 14. The assembly of claim 9, where the distal end of the anchors is bioabsorbable. 15. The assembly of claim 9, further comprising a fastener adapted to maintain a tensile force within the tensioning element once the tensioning element cinches the anchors and tissues. 16. The assembly of claim 15, where the fastener is adapted to allow unidirectional tensioning within the tensioning element. 17. The assembly of claim 15, where the fastener comprises a ratchet biased to remain in contact with the tensioning element. 18. The assembly of claim 9, where the tensioning element comprises a suture or a wire.
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