Devices and methods for facilitating controlled bone growth or repair
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61B-017/70
A61F-002/44
출원번호
US-0412048
(2012-03-05)
등록번호
US-8523908
(2013-09-03)
발명자
/ 주소
Malone, David G.
출원인 / 주소
DePuy Synthes Products LLC
대리인 / 주소
Nutter McClennen & Fish LLP
인용정보
피인용 횟수 :
26인용 특허 :
149
초록▼
Bone implantable devices and methodologies permit careful application of biologically active substances and management of bone growth processes. The device includes a body defining a carrier receiving area for locating adjacent bone. Carrier material is located in the carrier receiving area. Substan
Bone implantable devices and methodologies permit careful application of biologically active substances and management of bone growth processes. The device includes a body defining a carrier receiving area for locating adjacent bone. Carrier material is located in the carrier receiving area. Substance is delivered onto carrier material through a port. A pathway delivers substance from the carrier receiving area to the bone surface. The body may be in the form of a spinal fusion cage, facet fusion screw, artificial joint, bone fixation plate, interbody graft, IM nail, hip stem, or other bone-to-bone appliances or bone-to-device appliances. In use, carrier is installed in the carrier receiving area of the device. The device is then implanted adjacent a bone. The substance is applied to the carrier for subsequent delivery to the bone. By doping carrier material after device implantation, inadvertent contact of the substance with non-target bone is more easily eliminated.
대표청구항▼
1. A facet screw, comprising: a threaded body defining an outside surface and configured to fuse a facet joint, said body having a size that facilitates passing said body through a superior facet of a lower vertebra and an inferior facet of an upper vertebra;a carrier receiving area defined by said
1. A facet screw, comprising: a threaded body defining an outside surface and configured to fuse a facet joint, said body having a size that facilitates passing said body through a superior facet of a lower vertebra and an inferior facet of an upper vertebra;a carrier receiving area defined by said body configured to receive a carrier material;a port that communicates said outside surface with said carrier receiving area for facilitating delivery of a biologically active substance onto said carrier material, wherein the port comprises a self-sealing member disposed therein;a pathway that communicates with said carrier receiving area for delivering said biologically active substance from said carrier receiving area to a target bone structure. 2. The facet screw of claim 1, wherein said body is configured to pass through said superior facet of said lower vertebra from a location adjacent a superior process of said lower vertebra and through said inferior facet of said upper vertebra. 3. The facet screw of claim 1, wherein said body is configured to pass through said inferior facet of said upper vertebra from a location adjacent a spinous process of said upper vertebra and through said superior facet of said lower vertebra. 4. The facet screw of claim 1, wherein the self-sealing member is configured to be penetrated by a syringe and to prevent substance from within the carrier receiving area from exiting the port. 5. The facet screw of claim 1, wherein said outside surface has perforated zones and non-perforated zones. 6. The facet screw of claim 5, wherein, upon implantation, the perforated zones are configured to be in contact with an adjacent bone structure to allow bone growth therethrough. 7. The facet screw of claim 6, wherein, upon implantation, no area of the perforated zones are not in contact with adjacent bone structure. 8. The facet screw of claim 1, wherein the body comprises an elongate member having a distal end and a proximal end and a thread extending over at least a portion of the outer surface, and wherein the pathway comprises a plurality of apertures extending through the outer surface. 9. The facet screw of claim 8, wherein the apertures extend through the outer surface between adjacent ridges of the thread. 10. The facet screw of claim 8, wherein the apertures are longitudinally separated. 11. The facet screw of claim 8, wherein the thread extends continuously from a first position distal to at least one of the apertures to a second position proximal to the at least one aperture. 12. An implant, comprising: a facet screw comprising an elongate threaded body having a proximal end, a distal end, and an outer surface extending therebetween, the elongate body configured to fuse a facet joint and having a size that facilitates passing the body through a superior facet of a lower vertebra and an inferior facet of an upper vertebra;a carrier receiving area defined by the body configured to receive a carrier material;an end cap located on the proximal end of the body configured to seal the carrier receiving area; anda pathway that communicates with the carrier receiving area for delivering the biologically active substance from the carrier receiving area to a target bone structure. 13. The implant of claim 12, wherein the end cap has a maximum diameter greater than a maximum diameter of the elongate body. 14. The implant of claim 12, wherein the end cap includes a self-sealing injection port disposed therein for facilitating delivery of a biologically active substance into the carrier receiving area. 15. An implant, comprising: a facet screw comprising a proximal head;a threaded body extending distally from the head and having a diameter less than a diameter of the proximal head, the threaded body defining an outside surface and configured to fuse a facet joint, the body having a size that facilitates passing the body through a superior facet of a lower vertebra and an inferior facet of an upper vertebra;a carrier receiving area defined by the body configured to receive a carrier material; anda plurality of apertures formed in the outside surface that communicate with the carrier receiving area for delivering said biologically active substance from said carrier receiving area to a target bone structure, the plurality of apertures configured to be adjacent at least one of the superior facet of the lower vertebra and the inferior facet of the upper vertebra,wherein the outside surface includes a single continuous perforated zone and a non-perforated zone, the perforated zone comprising all of the plurality of apertures and configured to be adjacent the superior facet and the inferior facet upon implantation, and wherein the non-perforated zone is configured to face away from the facet joint upon implantation. 16. The implant of claim 15, further comprising a self-sealing injection port located on a proximal surface of the proximal head that facilitates delivery of a biologically active substance onto the carrier material in the carrier receiving area. 17. The implant of claim 16, wherein the port is hexagonal.
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