IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0665531
(2012-10-31)
|
등록번호 |
US-8529880
(2013-09-10)
|
우선권정보 |
AU-2002950340 (2002-07-23) |
발명자
/ 주소 |
- Adhikari, Raju
- Gunatillake, Pathiraja Arachchillage
|
출원인 / 주소 |
- Polynovo Biomaterials Pty Limited
|
대리인 / 주소 |
Novak Druce Connelly Bove + Quigg LLP
|
인용정보 |
피인용 횟수 :
0 인용 특허 :
16 |
초록
▼
The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are de
The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.
대표청구항
▼
1. A biodegradable, biocompatible polyurethane/urea polymer composition comprising the reaction product of: a) a flowable prepolymer comprising the reaction product of: i) one or more isocyanates; andii) one or more multifunctional core molecules having a molecular weight of 400 or less and at least
1. A biodegradable, biocompatible polyurethane/urea polymer composition comprising the reaction product of: a) a flowable prepolymer comprising the reaction product of: i) one or more isocyanates; andii) one or more multifunctional core molecules having a molecular weight of 400 or less and at least two functional groups that react with said isocyanate thereby forming urethane or urea groups; andb) one or more soft segment-forming functional oligomers chosen from: i) linear oligomers;ii) star oligomers;iii) dendrimeric oligomers; andiv) hyperbranched oligomers;wherein the functional oligomer has degradable arms and is selected from the group consisting of lactides, glycolides, lactide/glycolides, caprolactones, propylene fumarates, glycolic acid, dioxanones, anhydrides and polyorthoesters;wherein the flowable prepolymer is curable with the functional oligomer at 30° C.; andwherein the polymer composition comprises one or more bioactive moieties. 2. The biodegradable, biocompatible polyurethane/urea polymer composition according to claim 1 wherein the one or more bioactive moieties is chemically bonded to the composition. 3. The biodegradable, biocompatible polyurethane/urea polymer composition according to claim 1 wherein the one or more bioactive moieties is chemically bonded to the composition via one or more hydrolysable linkages. 4. The biodegradable, biocompatible polyurethane/urea polymer composition according to claim 1 wherein the one or more bioactive moieties is chemically bonded to the multifunctional core molecule. 5. The biodegradable, biocompatible polyurethane/urea polymer composition according to claim 4 wherein the multifunctional core molecule has one of the following structures: [H]m-A-[B]n;[H-D]m-A-[E-B]n; or[H-D]m-A-[(E)p-B]n whereinA is a core molecule sub-structure;H is an active hydrogen atom;B is a bioactive moiety which is bound to A via one or more hydrolysable linkages;D is a degradable arm comprising one or more hydrolysable linkages and which is bound to A via the one or more hydrolysable linkages, said degradable arm being terminated by an active hydrogen atom;E is a degradable arm comprising one or more hydrolysable linkages and which is bound to A via the one or more hydrolysable linkages, said degradable arm being terminated by a bioactive moiety B via a hydrolysable linkage;m is an integer of 2 or greater;n is an integer of 1 or greater; andp is an integer of 1 or greater. 6. The biodegradable, biocompatible polyurethane/urea polymer composition according to claim 1 wherein the one or more bioactive moieties is chemically bonded to the isocyanate. 7. The biodegradable, biocompatible polyurethane/urea polymer composition according to claim 1 wherein the one or more bioactive moieties is chemically bonded to the functional oligomer. 8. The biodegradable, biocompatible polyurethane/urea polymer composition according to claim 1 wherein the bioactive moiety is selected from the group consisting of ascorbic acid, glycerol, glucose, lysine, lactic acid and ethanol. 9. The biodegradable, biocompatible polyurethane/urea polymer composition according to claim 1 wherein the one or more bioactive moieties is hydrolytically releasable from the polymer composition. 10. The biodegradable, biocompatible polyurethane/urea polymer composition according to claim 1 wherein the one or more bioactive moiety is hydrolytically releasable at a rate that is faster than the degradation rate of the biodegradable polymer backbone. 11. A biodegradable, biocompatible polyurethane/urea polymer composition according to claim 1, comprising the reaction product of: (a) a flowable prepolymer comprising the reaction product of any one of ascorbic acid, glycerol or glucose and diisocyanate, and(b) a functional oligomer having degradable arms. 12. A biodegradable, biocompatible polyurethane/urea polymer composition according to claim 1 where the bioactive moiety is a phosphorylcholine. 13. A biodegradable, biocompatible polyurethane/urea polymer composition according to claim 1, comprising the reaction product of: (a) a flowable prepolymer comprising the reaction product of a multifunctional core molecule and diisocyanate, and(b) the reaction product of polycaprolactone triol and phosphoryl choline. 14. A biodegradable, biocompatible polyurethane/urea polymer composition according to claim 1, comprising the reaction product of: (a) a flowable prepolymer comprising the reaction product of a multifunctional core molecule and diisocyanate, and(b) the reaction product of ethylene glycol, lactide and polycaprolactone triol. 15. A biodegradable, biocompatible polyurethane/urea polymer composition according to claim 1, comprising the reaction product of: (a) a flowable prepolymer comprising the reaction product of a multifunctional core molecule and ethyl 2,6-diisocyanato hexanoate, and(b) a functional oligomer having degradable arms. 16. The biodegradable, biocompatible polyurethane/urea polymer composition according to claim 1 wherein the one or more bioactive moieties comprises gelatine or hydroxyapatite. 17. A biodegradable, biocompatible polyurethane/urea polymer composition according to claim 1 further comprising one or more chain extenders. 18. A biodegradable, biocompatible polymeric scaffold comprising a cured biocompatible, biodegradable polyurethane/urea composition according to claim 1. 19. A process for the preparation of a biocompatible, biodegradable polyurethane/urea composition according to claim 1, comprising reacting one or more isocyanates with one or more multifunctional core molecules having a molecular weight less than 400 so as to form a flowable prepolymer having urethane or urea groups; andreacting said prepolymer with one or more functional oligomers with degradable arms and optionally, appropriate amounts of water and catalyst under conditions such that the reaction temperature does not exceed 90° C. 20. A process according to claim 19 optionally comprising the addition of one or more chain extenders. 21. A method of treatment of damaged bone or cartilage in a patient requiring such treatment, the method comprising administering to said patient a biocompatible, biodegradable polyurethane/urea composition according to claim 1, said administration occurring by the implant of a scaffold formed ex vivo from a cured form of said polyurethane/urea composition, or by the injection of said polymer in an uncured form for in vivo curing and scaffold formation. 22. A process of repairing bone or cartilage comprising integrating the scaffold according to claim 17 with said bone or cartilage.
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