IPC분류정보
| 국가/구분 |
United States(US) Patent
등록
|
| 국제특허분류(IPC7판) |
|
| 출원번호 |
US-0177147
(2011-07-06)
|
| 등록번호 |
US-8529961
(2013-09-10)
|
|
발명자
/ 주소 |
- Campbell, Phil G.
- Burgess, James E.
- Weiss, Lee E.
- Smith, Jason
|
| 출원인 / 주소 |
- Carmell Therapeutics Corporation
|
| 대리인 / 주소 |
|
| 인용정보 |
피인용 횟수 :
3 인용 특허 :
119 |
초록
▼
Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the
Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.
대표청구항
▼
1. A coating comprising a blood plasma-derived plastic, wherein the blood plasma-derived plastic comprises at least partially dried clotted blood plasma, wherein the clotted blood plasma comprises whole plasma, including a plasma clot and serum. 2. The coating of claim 1, wherein the coating is a sh
1. A coating comprising a blood plasma-derived plastic, wherein the blood plasma-derived plastic comprises at least partially dried clotted blood plasma, wherein the clotted blood plasma comprises whole plasma, including a plasma clot and serum. 2. The coating of claim 1, wherein the coating is a sheet or film. 3. The coating of claim 1, wherein the coating is applied or adhered to a device. 4. The coating of claim 3, wherein the device is selected from the group consisting of a medical device, surgical instrument, diagnostic instrument, drug delivery device, and prosthetic implant. 5. The coating of claim 3, wherein the device is to be used in the body or in contact with bodily fluids. 6. The coating of claim 3, wherein the device is selected from the group consisting of a pacemaker, defibrillator, stent, orthopedic implant, urological implant, dental implant, breast implant, tissue augmentation, heart valve, artificial cornea, bone reinforcement, implant for maxillofacial reconstruction, percutaneous catheter, percutaneous cannulae, catheter, urinary catheter, percutaneous electrical wire, ostomy appliance, and electrode. 7. The coating of claim 1, wherein the blood plasma-derived plastic comprises one or more of a plasticizer, stabilizer, drug or other therapeutic, filler, porogen, crosslinker, biological response modifier, polymeric material, tracer, labeled compound, and metal ion. 8. The coating of claim 7, wherein the biological response modifier is a bioactive protein selected from the group consisting of hormones, growth factors, cytokines, extracellular matrix molecules, and mixtures thereof. 9. The coating of claim 8, wherein the bioactive protein comprises at least one growth factor selected from the group consisting of platelet derived growth factors (PDGF), acidic and basic fibroblast growth factors, transformation growth factor beta (TGF-beta), insulin like growth factors (IGF), epidermal growth factors (EGF), platelet-derived angiogenesis factors (PDAF), platelet-derived endothelial growth factors (PDEGF), tumor necrosis factor-alpha (TNF-α), tumor necrosis factor-beta (TNF-β), vascular endothelial growth factors (VEGF), epithelial cell growth factors (ECGF), granulocyte-colony stimulating factors (G-CSF), granulocyte-macrophage colony stimulating factors (GM-CSF), nerve growth factors (NGF), neurotrophins, erythropoietin (EPO), thrombopoietin (TPO), myostatin (GDF-8), growth differentiation factor-9 (GDF9), hepatocyte growth factors (HGF), platelet factors, and mixtures thereof. 10. The coating of claim 8, wherein the bioactive protein comprises at least one extracellular matrix molecule selected from the group consisting of osteocalcin, osteonectin, fibrinogen, vitronectin, fibronectin, thrombospondin 1 (TSP-1), bone sialoprotein (BSP), proteoglycans and mixtures thereof. 11. The coating of claim 7, wherein the plasticizer is selected from the group consisting of water, glycerol, and mixtures thereof. 12. The coating of claim 11, wherein the plasticizer is glycerol. 13. The coating of claim 7, wherein the crosslinker is selected from the group consisting of carbodiimides, Factor XIII, dihomo bifunctional NHS esters, genipin, and mixtures thereof. 14. The coating of claim 13, wherein the crosslinker is genipin. 15. The coating of claim 7, wherein the drug is selected from the group consisting of analgesics; anti-infective agents; antineoplastics; biologicals; blood modifiers; cardioprotective agents; cardiovascular agents; cholinesterase inhibitors; hormones; immunomodulators; immunosuppressives; ophthalmic preparations; respiratory agents; anti-inflammatory agents; skin and mucous membrane agents; anti-cancer agents; and mixtures thereof. 16. The coating of claim 8, wherein the porogen is soluble in an aqueous phase. 17. The coating of claim 7, wherein the blood plasma-derived plastic comprises at least one biological response modifier. 18. The coating of claim 17, wherein the blood plasma-derived plastic comprises at least one biological response modifier that is heat-sensitive. 19. The coating of claim 1, wherein the coating is pliant, elastic, or a combination thereof. 20. The coating of claim 1, wherein the coating is rigid. 21. The coating of claim 1, wherein the coating comprises a gradient of physical or chemical characteristics. 22. The coating of claim 21, wherein the physical characteristics are selected from the group consisting of one or more of density, porosity, elasticity and tensile strength. 23. The coating of claim 21, wherein the chemical characteristics comprise a variation in the concentration of one or more additional agents. 24. The coating of claim 23, wherein the additional agents are selected from the group consisting of one or more of a plasticizer, stabilizer, growth factor, drug or other therapeutic, filler, porogen, crosslinker, biological response modifier, polymeric material, tracer, labeled compound, and metal ion. 25. The coating of claim 21, wherein the coating has multiple gradients. 26. The coating of claim 1, wherein the coating comprises cells seeded in or on the coating. 27. The coating of claim 26, wherein the cells are stem cells. 28. The coating of claim 27, wherein the stem cells are embryonic, adult, autologous, allogenic, or xenogenic stem cells. 29. The coating of claim 1, wherein the blood plasma-derived plastic retains biological activity. 30. The coating of claim 1, wherein the coating is applied as a putty. 31. The coating of claim 1, wherein the whole plasma is obtained from an autologous donor. 32. The coating of claim 1, wherein the whole plasma is obtained from allogeneic donors. 33. The coating of claim 1, wherein the at least partially dried clotted blood plasma is essentially fully dried. 34. The coating of claim 1, wherein the platelet concentration of the whole plasma in the blood plasma-derived plastic is increased compared to a baseline platelet concentration of whole plasma.
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