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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0463183 (2009-05-08) |
등록번호 | US-8532731 (2013-09-10) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 0 인용 특허 : 287 |
A region of skin, other than the fingertips, is stimulated. After stimulation, an opening is created in the skin (e.g., by lancing the skin) to cause a flow of body fluid from the region. At least a portion of this body fluid is transported to a testing device where the concentration of analyte (e.g
A region of skin, other than the fingertips, is stimulated. After stimulation, an opening is created in the skin (e.g., by lancing the skin) to cause a flow of body fluid from the region. At least a portion of this body fluid is transported to a testing device where the concentration of analyte (e.g., glucose) in the body fluid is then determined. It is found that the stimulation of the skin provides results that are generally closer to the results of measurements from the fingertips, the traditional site for obtaining body fluid for analyte testing.
1. A method of determining a concentration of an analyte in blood, the method comprising steps of: stimulating a region of skin other than a fingertip by manually rubbing the exterior surface of the region for a duration of at least 1 second;after stimulating the region of skin, creating an opening
1. A method of determining a concentration of an analyte in blood, the method comprising steps of: stimulating a region of skin other than a fingertip by manually rubbing the exterior surface of the region for a duration of at least 1 second;after stimulating the region of skin, creating an opening in the region of skin to cause a flow of blood from the region of skin;coupling a electrochemical sensor strip to a meter, wherein the sensor strip comprises: a sample chamber for holding blood, the sample chamber comprising a working electrode, wherein the sample chamber is sized to contain a volume of no more than about 1 μL of blood;a first electrode and a second electrode disposed in the sample chamber and flanking the working electrode, wherein the first electrode indicates when the sample chamber is beginning to fill with sample, and the second electrode indicates when the sample chamber is substantially filled with sample; andan analyte-responsive enzyme and a redox mediator disposed in the sample chamber;contacting the sensor strip to the blood;transporting no more than 1 microliter of the blood to the sample chamber via an un-pressurized mode of transport;determining when the sample chamber is beginning to fill with sample;determining when the sample chamber is substantially filled with sample; andelectrochemically determining the concentration of the analyte in the blood using the electrochemical sensor strip and meter. 2. The method of claim 1, wherein the step of creating an opening in the region of skin comprises lancing the region of skin. 3. The method of claim 1, wherein the step of stimulating the region of skin comprises manually rubbing the region of skin for at least five seconds. 4. The method of claim 1, wherein the step of stimulating the region of skin comprises stimulating a region of skin on a forearm. 5. The method of claim 1, wherein the step of stimulating the region of skin comprises stimulating a region of skin on a calf. 6. The method of claim 1, wherein the step of stimulating the region of skin comprises stimulating a region of skin on a thigh. 7. The method of claim 1, wherein the step of stimulating the region of skin comprises stimulating a region of skin on a hand. 8. The method of claim 1, wherein the step of stimulating the region of skin comprises stimulating a region of skin on a portion of an upper arm. 9. The method of claim 1, wherein the step of stimulating the region of skin comprises stimulating a region of skin on an abdomen. 10. The method of claim 1, wherein stimulating the region of skin results in a determination of the concentration of the analyte from blood which is at least 10% nearer a concentration determined from blood obtained from a fingertip than a determination of the concentration of the analyte from blood obtained from the region of skin without stimulating. 11. The method of claim 1, wherein the fingertip measurement is in the range of 60 to 80 mg/dL. 12. The method of claim 1, wherein the step of transporting no more than 1 microliter of the blood to the sample chamber comprises transporting no more than 0.5 microliter of blood to the sample chamber. 13. The method of claim 1, wherein the step of transporting no more than 1 microliter of the blood to the sample chamber comprises transporting no more than 0.25 microliter of blood to the sample chamber. 14. The method of claim 1, wherein the step of electrochemically determining the concentration of the analyte comprises determining the concentration of the analyte using coulometry. 15. The method of claim 1, wherein the step of electrochemically determining the concentration of the analyte comprises determining the concentration of the analyte using amperometry. 16. The method of claim 1, wherein the step of electrochemically determining the concentration of the analyte comprises determining the concentration of the analyte using potentiometry. 17. The method of claim 1, wherein the analyte is glucose or a ketone body. 18. The method of claim 17, wherein the analyte is glucose and the analyte-responsive enzyme is glucose dehydrogenase. 19. A method of determining a concentration of an analyte in blood, the method comprising steps of: stimulating a region of skin other than a fingertip by manually rubbing the skin for a period of time adequate to obtain an analyte measurement that is at least 10% nearer a concentration determined from blood obtained from a fingertip measurement than a determination of the concentration of the analyte from blood obtained from the region of skin without stimulating;after stimulating the region of skin, lancing the region of skin to cause a flow of blood from the region;coupling an electrochemical sensor strip to a meter, wherein the sensor strip comprises: a sample chamber for holding blood, the sample chamber comprising a working electrode, wherein the sample chamber is sized to contain a volume of no more than about 1 μL of blood;a first electrode and a second electrode disposed in the sample chamber and flanking the working electrode, wherein the first electrode indicates when the sample chamber is beginning to fill with sample, and the second electrode indicates when the sample chamber is substantially filled with sample; andan analyte-responsive enzyme and a redox mediator disposed in the sample chamber;contacting the sensor strip to the blood and transporting no more than about 1 microliter of the blood to the sample chamber;determining when the sample chamber is beginning to fill with sample;determining when the sample chamber is substantially filled with sample; andelectrochemically determining the concentration of the analyte by coulometry, amperometry or potentiometry using the electrochemical sensor strip and meter. 20. The method of claim 19, wherein the step of stimulating the region of skin comprises manually rubbing the forearm skin for a period of at least one second. 21. The method of claim 19, wherein the step of stimulating the region of skin comprises manually rubbing the forearm skin for a period of at least 2 seconds. 22. The method of claim 19, wherein the step of stimulating the region of skin comprises manually rubbing the forearm skin for a period of at least 5 seconds. 23. The method of claim 19, wherein the step of transporting no more than about 1 microliter of the blood to the sample chamber comprises transporting no more than about 0.5 microliter of the blood. 24. The method of claim 23, wherein the step of transporting no more than about 0.5 microliter of the blood to the sample chamber comprises transporting no more than about 0.25 microliter of the blood. 25. The method of claim 24, wherein the step of transporting no more than about 0.25 microliter of the blood to the sample chamber comprises transporting no more than about 0.1 microliter of the blood. 26. The method of claim 19, wherein the step of coupling an electrochemical sensor strip comprises coupling a tip-fill electrochemical sensor strip. 27. The method of claim 19, wherein the step of coupling an electrochemical sensor strip comprises coupling a side-fill electrochemical sensor strip. 28. The method of claim 19 wherein the fingertip measurement is in the range of 60 to 80 mg/dL. 29. The method of claim 19, wherein the step of stimulating the region of skin comprises stimulating a region of skin on a forearm. 30. The method of claim 19, wherein the step of stimulating the region of skin comprises stimulating a region of skin on a calf. 31. The method of claim 19, wherein the step of stimulating the region of skin comprises stimulating a region of skin on a thigh. 32. The method of claim 19, wherein the step of stimulating the region of skin comprises stimulating a region of skin on a hand. 33. The method of claim 19, wherein the step of stimulating the region of skin comprises stimulating a region of skin on a portion of an upper arm. 34. The method of claim 19, wherein the step of stimulating the region of skin comprises stimulating a region of skin on an abdomen. 35. The method of claim 19, wherein the analyte is glucose or a ketone body. 36. The method of claim 35, wherein the analyte is glucose and the analyte-responsive enzyme is glucose dehydrogenase.
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