[특허]Biocompatible polymers and hydrogels and methods of use

Biocompatible polymers and hydrogels and methods of use 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61F-002/00
출원번호	US-0985588 (2007-11-16)
등록번호	US-8535705 (2013-09-17)
발명자 / 주소	Pathak, Chandrashekhar P. Sawhney, Amarpreet S. Edelman, Peter G.
출원인 / 주소	Incept, LLC
대리인 / 주소	Dardi & Herbert, PLLC.
인용정보	피인용 횟수 : 0 인용 특허 : 165

초록 ▼

Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable or not are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants.

대표청구항 ▼

1. A method of making a biocompatible degradable hydrogel to treat a medical condition of a patient comprising: identifying a medical condition for treatment by use of a hydrogel formed in situ in a patient and fully degradable in a patient in less than about 180 days; andmixing a first precursor with a second precursor in situ in the patient to form the hydro gel for treatment of the medical condition,with the first biocompatible synthetic hydrophilic polymer precursor having a water solubility of at least 1 gram per 100 milliliters and comprising at least two electrophilic functional groups; and the second biocompatible synthetic hydrophilic polymer precursor comprising at least two nucleophilic amine functional groups; andwherein (i) the first precursor is selected have only one or two chemically hydrolytically degradable ester bonds per every electrophilic functional group on the first precursor; and(ii) the second precursor comprises at least three nucleophilic functional groups;wherein the biodegradable groups of the hydrogel consist of the esters and the hydrogel as placed in situ in the patient is essentially fully degradable in a patient in less than about 180 days, andwherein mixing the first and the second synthetic hydrophilic polymer precursors forms crosslinking covalent bonds that are reaction products of the electrophilic and the nucleophilic groups, wherein essentially every ester bond in the hydrogel is separated from other ester bonds in the hydrogel by at least three covalent bonds when the hydrogel is formed. 2. The method of claim 1 wherein the medical condition is adhesion prevention. 3. The method of claim 1 wherein the medical condition is tissue adhesion. 4. The method of claim 1 wherein the medical condition is drug delivery. 5. The method of claim 1 wherein the medical condition is wound covering. 6. The method of claim 1 wherein the medical condition is tissue sealing. 7. The method of claim 1 wherein the medical condition is tissue coating. 8. The method of claim 1 wherein the solids concentration of the hydrogel ranges from 8.5% to 20% w/w. 9. The method of claim 1 wherein the second precursor has a molecular weight of less than about 1000 Daltons. 10. The method of claim 1 wherein the first precursor comprises carboxymethyl-hydroxybutyrate-N-hydroxysuccinimidyl polyethylene glycol. 11. The method of claim 1 wherein the first precursor comprises succinimidyl glutarate. 12. The method of claim 1 wherein the electrophilic functional groups of the first precursor comprise n-hydroxysuccinimide ester. 13. The method of claim 1 wherein the electrophilic functional groups of the first precursor comprise a member of the group consisting of carbonyldiimidazole, sulfonyl chloride, aryl halides, sulfosuccinimide ester, epoxide, aldehyde, maleimides and imidoester. 14. The method of claim 1 wherein the second precursor consists essentially of a member of the group consisting of dilysine, trilysine, and tetralysine. 15. The method of claim 1 wherein at least one of the precursors is selected to further comprise a chemical group having the formula (CH2CH2O)n. 16. The method of claim 1 wherein the second precursor comprises a lysine. 17. The method of claim 1 wherein the hydrogel is essentially fully degradable in a patient in less than about 90 days. 18. The method of claim 1 wherein the hydrogel is essentially fully degradable in a patient in less than about 45 days.

이 특허에 인용된 특허 (165)

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Hubbell Jeffrey A. (Austin TX) Pathak Chandrashekhar P. (Waltham MA) Sawhney Amarpreet S. (Newton MA) Desai Neil P. (Los Angeles CA) Hill-West Jennifer L. (Austin TX), Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers.
상세보기
Hubbell Jeffrey A. ; Pathak Chandrashekhar P. ; Sawhney Amarpreet S. ; Desai Neil P. ; Hill Jennifer L., Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers.
상세보기
Hubbell Jeffrey A. ; Pathak Chandrashekhar P. ; Sawhney Amarpreet S. ; Desai Neil P. ; Hill-West Jennifer L., Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers.
상세보기
Zalipsky Samuel (Princeton NJ) Bolikal Durgadas (Edison NJ) Nathan Aruna (Piscataway NJ) Kohn Joachim B. (Highland Park NJ), Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon.
상세보기
Zalipsky Samuel (Princeton NJ) Bolikal Durgadas (Edison NJ) Nathan Aruna (Piscataway NJ) Kohn Joachim B. (Highland Park NJ), Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon.
상세보기
Coury Arthur J. ; Avila Luis Z. ; Pathak Chandrashekhar P. ; Barman Shikha P., Poly(hydroxy acid)/polymer conjugates for skin applications.
상세보기
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Polymer conjugates ophthalmic devices comprising collagen-polymer conjugates.
상세보기
Russell Alan J. ; Beckman Eric J. ; Andreopoulos Fotios M. ; Wagner William R., Polymer for reversible photoinduced sol gel transitions.
상세보기
Sawhney Amarpreet S. ; Jarrett Peter K. ; Coury Arthur J. ; Rudowsky Ronald S. ; Powell Michelle D. ; Avila Luis Z. ; Enscore David J. ; Goodrich Stephen D. ; Nason William C. ; Yao Fei ; Weaver Doug, Polymerizable biodegradable polymers including carbonate or dioxanone linkages.
상세보기
Russell Alan J. ; Beckman Eric J. ; Andreopoulos Fotios M. ; Wagner William R., Polymers for reversible photoinduced sol gel transitions.
상세보기
Veronese Francesco M. (Padua ITX) Schiavon Oddone (Padua ITX) Caliceti Paolo (Padua ITX) Sartore Luciana (Marano Vic. ITX) Ranucci Elisabetta (Brescia ITX) Ferruti Paolo (Milan ITX), Polymers of N-acryloylmorpholine activated at one end and conjugates with bioactive materials and surfaces.
상세보기
Cohn Daniel (Jerusalem ILX) Yitzchaiek Shlomo (Ramat Gan ILX) Bilenkis Sophie (Jerusalem ILX), Polyurethane-based polymeric materials and biomedical articles and pharmaceutical compositions utilizing the same.
상세보기
Morse Brenda S. (Chamblee GA) Turner A. Denise (Dunwoody GA) Carpenter John F. (Marietta GA), Preparation of fibrinogen/factor XIII precipitate.
상세보기
Rhee Woonza M. (Palo Alto CA) Berg Richard A. (Los Altos CA) Rosenblatt Joel S. (Palo Alto CA) Schroeder Jacqueline A. (Redwood City CA) Braga Larry J. (Fremont CA) Smestad Thomas L. (Palo Alto CA) F, Process for preparing a sterile, dry crosslinking agent.
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Chesterfield Michael P. (Norwalk CT) Muth Ross R. (Brookfield CT) Kennedy John (Stratford CT), Process for preparing particles of bioabsorbable polymer.
상세보기
Rubinstein ; Menachem ; Simon ; Shulamit ; Bloch ; deceased ; Rene, Process for the cross-linking of proteins.
상세보기
Bui-Khac Trung (Montreal CAX) Lavoie Lise (St-Eustache CAX) Michel St Picq Dominique (Ste-Genevive CAX), Process for the obtention of a biological adhesive made of concentrated coagulation factors by “salting-out”.
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Wallace Donald G. ; Cruise Gregory M. ; Rhee Woonza M. ; Schroeder Jacqueline Anne ; Coker ; III George T. ; Maroney Marcee M., Rapid gelling biocompatible polymer composition.
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Hsu Chung C. (Los Altos Hills) Nguyen Hoc M. (San Francisco) Wu Sylvia S. (San Ramon CA), Reconstitutable lyophilized protein formulation.
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Avoy Donald R. (5988 Garces Ave. San Jose CA 95123), Refillable fibrinogen dispensing kit.
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David Lentz ; Jamie Henderson ; Edward Dormier ; Richard Zdrahala ; Gary Loomis ; Ronald Rakos ; Krzysztof Sowinski, Self-sealing PTFE vascular graft and manufacturing methods.
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Harris J. Milton, Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution.
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Lonneman Alan (Plymouth MN) Miller Curtis H. (Burnsville MN), Sprayer assembly for physiologic glue.
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Pasque Michael K. (13218 Hawkshead Ct. Town and Country MO 63131), Sternal closure device.
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Matsuda Takehisa (Minoo JPX) Iwata Hiroo (Suita JPX) Itoh Tetsuo (Shiga JPX), Surgical adhesive.
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Baichwal Anand, Sustained release heterodisperse hydrogel systems--amorphous drugs.
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Hicks Allen J., Tapered and reinforced catheter.
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Schwarz Otto (Vienna ATX) Linnau Yendra (Vienna ATX) Lblich Franz (Vienna ATX) Seelich Thomas (Vienna ATX), Tissue adhesive.
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Bass Lawrence S. (Little Neck NY) Libutti Steven K. (Fort Lee NJ) Eaton Alexander M. (Durham NC), Tissue bonding and sealing composition and method of using the same.
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Jeffrey A. Hubbell CH; Chandrashekhar P. Pathak ; Amarpreet Sawhney ; Neil Desai ; Syed Hossainy ; Jennifer L. Hill-West, Treating medical conditions by polymerizing macromers to form polymeric materials.
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Shaw William J. (Cambridge MA), Treating wounds caused by medical procedures.
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Hedgepeth Joseph (San Francisco CA) Wachtel Helmut (Berlin DEX), Treatment of multiple sclerosis.
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Breitsprecher Charles O. (Plymouth MN), Two component fluid spray gun and method.
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Higham Paul A. (Ringwood NJ) Posey-Dowty Jessica D. (Kingsport TN), Use of derivatives of chitin soluble in aqueous solutions for preventing adhesions.
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Hamilton Raymond (Somerville MA) Fox Ellen M. (Cranston RI) Acharya Raksha A. (Northboro MA) Walts Alan E. (Brookline MA), Water insoluble derivatives of hyaluronic acid.
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Grasel Timothy G. (Laurel MD) Guthrie James L. (Ashton MD), Water-absorbent, high capacity polyurethane foams.
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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표IPC 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 공고번호, 공고일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표출원인, 출원인국적, 출원인주소, 발명자, 발명자E, 발명자코드, 발명자주소, 발명자 우편번호, 발명자국적, 대표IPC, IPC코드, 요약, 미국특허분류, 대리인주소, 대리인코드, 대리인(한글), 대리인(영문), 국제공개일자, 국제공개번호, 국제출원일자, 국제출원번호, 우선권, 우선권주장일, 우선권국가, 우선권출원번호, 원출원일자, 원출원번호, 지정국, Citing Patents, Cited Patents
저장형식	Text(ASCII format) Excel format PIAS분석(.xls)
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

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Biocompatible polymers and hydrogels and methods of use 원문보기

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