Highly reliable ingestible event markers and methods for using the same
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61B-005/00
A61M-037/00
출원번호
US-0744642
(2010-04-27)
등록번호
US-8545402
(2013-10-01)
국제출원번호
PCT/US2010/032590
(2010-04-27)
§371/§102 date
20100525
(20100525)
국제공개번호
WO2010/129288
(2010-11-11)
발명자
/ 주소
Hafezi, Hooman
Au-Yeung, Kityee
Duck, Robert
Holen, Maria
Robertson, Timothy
Costello, Benedict
출원인 / 주소
Proteus Digital Health, Inc.
대리인 / 주소
Bozicevic, Field & Francis LLP
인용정보
피인용 횟수 :
4인용 특허 :
255
초록▼
Ingestible event markers having high reliability are provided. Aspects of the ingestible event markers include a support, a control circuit, a first electrochemical material, a second electrochemical material and a membrane. In addition, the ingestible event markers may include one or more component
Ingestible event markers having high reliability are provided. Aspects of the ingestible event markers include a support, a control circuit, a first electrochemical material, a second electrochemical material and a membrane. In addition, the ingestible event markers may include one or more components that impart high reliability to the ingestible event marker. Further, the ingestible event markers may include an active agent. In some aspects, the active agent, such as a pharmaceutically active agent or a diagnostic agent may be associated with the membrane.
대표청구항▼
1. An ingestible event marker comprising: a circuitry element comprising: a control circuit comprising an upper surface and a lower surface;a first electrochemical material defining a first outer perimeter edge, the first electrochemical material electrically coupled to the upper surface of the cont
1. An ingestible event marker comprising: a circuitry element comprising: a control circuit comprising an upper surface and a lower surface;a first electrochemical material defining a first outer perimeter edge, the first electrochemical material electrically coupled to the upper surface of the control circuit; anda second electrochemical material defining a second outer perimeter edge, the second electrochemical material electrically coupled to the lower surface of the control circuit, wherein the first and second electrochemical materials are electrically isolated from each other;a membrane positioned between the first and second electrochemical materials comprising a signal amplification element comprising an insulating material positioned between the first and second electrochemical materials, the insulating material dimensioned to increase a length of the current path through conducting liquid in a body between the first and second electrochemical materials forming channels for the conducting fluid thereby boosting the conductance path therebetween, wherein the insulating material comprises a third outer edge extending beyond the first and second outer perimeter edges of the respective first and second electrochemical materials;wherein the first and second active electrode materials are configured to provide a voltage potential difference to the control circuit as a result of the first and second materials being in contact with the conducting liquid within the body; andwherein upon application of the voltage potential to the control circuit, the circuitry element generates a conductively transmitted signal comprising the current path that employs the body as a conduction medium such that the signal is conducted between the circuitry element and a receiver through the body tissues. 2. The ingestible event marker of claim 1 wherein the control circuit is electrically coupled to the first and second electrochemical materials, wherein the control circuit is configured to control a voltage potential difference between the first and second electrochemical materials. 3. The ingestible event marker according to claim 1 wherein the first and second electrochemical materials are configured to provide a voltage potential difference when in contact with a conducting liquid at a target physiological site, wherein the potential difference provides power for communication. 4. The ingestible event marker according to claim 1 wherein the membrane is a planar structure. 5. The ingestible event marker according to claim 1 wherein the membrane comprises at least one of multiple coatings and multiple layers. 6. The ingestible event marker of claim 1 further comprising at least one controlled activation element. 7. The ingestible event marker of claim 1 further comprising at least one of a non-active agent salt, an anti-foaming agent, a micro-environment modification agent and a soluble component comprising a weight equal or greater to 90% of the overall weight of the event marker. 8. The ingestible event marker according to claim 1 wherein the membrane comprises at least one of opposing curved edges, one or more projections, or one or more deployable elements. 9. The ingestible event marker of claim 1 further comprising a weight non-centrically positioned on the membrane. 10. The ingestible event marker of claim 1 further comprising a water-swellable component non-centrically positioned on the membrane. 11. The ingestible event marker according to claim 1, wherein the event marker comprises an active agent. 12. The ingestible event marker according to claim 11, wherein the membrane comprises the active agent. 13. The ingestible event marker according to claim 11, wherein the membrane is configured to controllably release the active agent. 14. The ingestible event marker according to claim 1, further comprising a solid component having a tablet configuration, wherein the tablet comprises at least one fluid passageway. 15. A system comprising: an ingestible event marker comprising:a circuitry element comprising: a control circuit comprising an upper surface and a lower surface;a first electrochemical material defining a first outer perimeter edge,the first electrochemical material electrically coupled to the upper surface of the control circuit; anda second electrochemical material defining a second outer perimeter edge, the second electrochemical material electrically coupled to the lower surface of the control circuit, wherein the first and second electrochemical materials are electrically isolated from each other;a membrane positioned between the first and second electrochemical materials comprising a signal amplification element comprising an insulating material positioned between the first and second electrochemical materials, the insulating material dimensioned to increase a length of the current path through conducting liquid in a body between the first and second electrochemical materials forming channels for the conducting fluid thereby boosting the conductance path therebetween, wherein the insulating material comprises a third outer edge extending beyond the first and second outer perimeter edges of the respective first and second electrochemical materialswherein the first and second active electrode materials are configured to provide a voltage potential difference to the control circuit as a result of the first and second materials being in contact with the conducting liquid within the body; andwherein upon application of the voltage potential to the control circuit, the circuitry element generates a conductively transmitted signal comprising the current path that employs the body as a conduction medium such that the signal is conducted between the circuitry element and a receiver through the body tissues. 16. The system of claim 15 wherein the ingestible event marker comprises an active agent. 17. The system of claim 15 wherein the active agent is located on the membrane. 18. The system of claim 15 wherein the event marker further comprises at least one of a non-active agent salt, an anti-foaming agent, a micro-environment modification agent and a soluble component having a weight equal or greater to 90% of the overall weight of the event marker. 19. The system of claim 15 wherein the membrane is a planar structure. 20. The system of claim 15 wherein the membrane comprises at least one of opposing curved edges, one or more projections, or one or more deployable elements.
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