Provided are methods of manufacturing microstructures, in which at least one viscous composition each containing at least one active ingredient is disposed directly or indirectly on a first substrate and/or a second substrate and the viscous composition(s) is elongated between the first and second s
Provided are methods of manufacturing microstructures, in which at least one viscous composition each containing at least one active ingredient is disposed directly or indirectly on a first substrate and/or a second substrate and the viscous composition(s) is elongated between the first and second substrates. The methods are simpler and more cost-effective.
대표청구항▼
1. A method of manufacturing a microstructure, the method comprising the steps of: (a) facing the inner surface of a first substrate with the inner surface of a second substrate, wherein the first substrate has a first viscous composition spotted directly or indirectly on the inner surface of the fi
1. A method of manufacturing a microstructure, the method comprising the steps of: (a) facing the inner surface of a first substrate with the inner surface of a second substrate, wherein the first substrate has a first viscous composition spotted directly or indirectly on the inner surface of the first substrate at predetermined positions and the second substrate has a second viscous composition spotted directly or indirectly on the inner surface of the second substrate at predetermined positions;(b) moving the first substrate, the second substrate, or both so as to allow the first viscous composition and the second viscous composition to become in contact with each other;(c) moving the first substrate, the second substrate, or both so as to allow the first viscous composition and the second viscous composition to be elongated;(d) solidifying the elongated first and second viscous compositions; and(e) cutting the solidified first and second viscous compositions at predetermined positions between the first substrate and the second substrate to provide a microstructure. 2. The method of claim 1, wherein at least one of the steps (a) to (e) is performed while air is blown. 3. The method of claim 1, wherein the step (a) comprises the steps of: (a-1) forming a first bottom layer on the first substrate by applying a first viscous material on the inner surface of the first substrate, solidifying the applied first viscous material, and spotting the first viscous composition on the first bottom layer; and(a-2) forming a second bottom layer on the second substrate by applying a second viscous material on the inner surface of the second substrate, solidifying the applied second viscous material, and spotting the second viscous composition on the second bottom layer. 4. The method of claim 3, wherein air is blown in at least one of the steps (a-1) and (a-2). 5. The method of claim 3, wherein the first bottom layer formed on the first substrate is a discontinuous layer comprising a plurality of spots spaced apart from each other, and the first viscous composition is spotted on all or part of the plurality of spots, and wherein the second bottom layer formed on the second substrate is a discontinuous layer comprising a plurality of spots spaced apart from each other, and the second viscous composition is spotted on all or part of the plurality of spots. 6. The method of claim 3, wherein the first viscous material is different from the second viscous material and the first viscous composition is different from the second viscous composition. 7. The method of claim 1, wherein the step (a) comprises the steps of: (a-1) forming a first bottom layer on the first substrate by applying a first viscous material on the inner surface of the first substrate, solidifying the applied first viscous material, forming a first top layer on the first bottom layer by applying a second viscous material on the first bottom layer, solidifying the applied second viscous material, and spotting the first viscous composition on the first top layer; and(a-2) forming a second bottom layer on the second substrate by applying a third viscous material on the inner surface of the second substrate, solidifying the applied third viscous material, forming a second top layer on the second bottom layer by applying a fourth viscous material on the second bottom layer, solidifying the applied fourth viscous material, and spotting the second viscous composition on the second top layer. 8. The method of claim 7, wherein air is blown in at least one of the steps (a-1) and (a-2). 9. The method of claim 7, wherein the first bottom layer formed on the first substrate, the first top layer formed on the first bottom layer, or both are discontinuous layers each comprising a plurality of spots spaced apart from each other, and the first viscous composition is spotted on all or part of the plurality of spots, and wherein the second bottom layer formed on the second substrate, the second top layer formed on the second bottom layer, or both are discontinuous layers each comprising a plurality of spots spaced apart from each other, and the second viscous composition is spotted on all or part of the plurality of spots. 10. The method of claim 7, wherein at lest one of the first, second, third, and fourth viscous materials is different from the other or others and the first viscous composition is different from the second viscous composition. 11. The method of claim 1, wherein the step (c) comprises the steps of: (c-1) elongating the first and second viscous compositions for a first predetermined time period;(c-2) stopping the elongation for a second predetermined time period; and(c-3) further elongating the elongated first and second viscous compositions for a third predetermined time period. 12. The method of claim 11, wherein air is blown in at least one of the steps (c-1) to (c-3). 13. The method of claim 1, wherein the first viscous composition contains at least one first active ingredient that can induce a pharmacological or cosmetic effect when being introduced into a subject and the second viscous composition contains at least one second active ingredient that can induce a pharmacological or cosmetic effect when being introduced into a subject. 14. The method of claim 13, wherein the first active ingredient is different from the second active ingredient and the pharmacological or cosmetic effect induced by the first active ingredient is the same as or different from the pharmacological or cosmetic effect induced by the second active ingredient. 15. The method of claim 1, wherein the first viscous composition, the second viscous composition, or both contain at least one biocompatible material, at least one biodegradable material, or a combination thereof. 16. The method of claim 1, wherein at least a portion of the microstructure contains an active ingredient that can induce a first pharmacological or cosmetic effect when being introduced into a subject and at least one of the other portions of the microstructure contains a different active ingredient that can, when being introduced into a subject, induce a pharmacological or cosmetic effect that is the same as or different from the first pharmacological or cosmetic effect. 17. A method of manufacturing a microstructure, the method comprising the steps of: (a) facing the inner surface of a first substrate with the inner surface of a second substrate, wherein the first substrate has a first viscous composition spotted directly or indirectly on the inner surface of the first substrate at predetermined positions and the second substrate has a second viscous composition spotted directly or indirectly on the inner surface of the second substrate at predetermined positions; (b) moving the first substrate, the second substrate, or both so as to allow the first viscous composition and the second viscous composition to become in contact with each other; (c) moving the first substrate, the second substrate, or both in opposite directions at a first speed so as to allow the first viscous composition and the second viscous composition to elongated; (d) blowing air directly or indirectly to the first and second viscous compositions to solidify the first and second viscous compositions; and (e) moving the first substrate, the second substrate, or both at a second speed higher than the first speed so as to cut the solidified first and second viscous compositions.
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이 특허를 인용한 특허 (1)
Falo, Jr., Louis D.; Erdos, Geza; Ozdoganlar, O. Burak, Tip-loaded microneedle arrays for transdermal insertion.
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