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Stabilized protein crystals, formulations comprising them and methods of making them

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C07C-007/14
  • C07C-007/20
  • C01C-001/18
출원번호 US-0609650 (2009-10-30)
등록번호 US-8558048 (2013-10-15)
발명자 / 주소
  • Margolin, Alexey L.
  • Khalaf, Nazar K.
  • St. Clair, Nancy L.
  • Rakestraw, Scott L.
  • Shenoy, Bhami C.
출원인 / 주소
  • Althea Technologies, Inc.
대리인 / 주소
    Wilson, Sonsini, Goodrich & Rosati
인용정보 피인용 횟수 : 0  인용 특허 : 43

초록

This invention relates to methods for the stabilization, storage and delivery of biologically active macromolecules, such as proteins, peptides and nucleic acids. In particular, this invention relates to protein or nucleic acid crystals, formulations and compositions comprising them. Methods are pro

대표청구항

1. A formulation, said formulation comprising: (a) a protein crystal, and(b) at least one excipient selected from the group consisting of sucrose, trehalose, lactitol, gelatin, hydroxypropyl-β-cyclodextrin, and methoxypolyethylene glycol, wherein the amount of methoxypolyethylene glycol in the formu

이 특허에 인용된 특허 (43)

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  2. Hopkins Thomas R. (Bartlesville OK), Alcohol removal from blood with alcohol oxidase.
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  5. Margolin Alexey L. ; Persichetti Rose A. ; St. Clair Nancy L. ; Khalaf Nazer K., Controlled dissolution crosslinked protein crystals.
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  9. Grau Ulrich (Hofheim am Taunus DEX), Crystal suspensions of insulin derivatives, processes for their preparation and their use.
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  11. Carter Daniel C. (Decatur AL), Crystals of serum albumin for use in genetic engineering and rational drug design.
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