초록 ▼

The current techniques provide a system for monitoring a physiological parameter of a patient using microneedles that are coupled to an optical system, allowing spectroscopic measurements to be made immediately below the outer layer of the epidermis. In embodiments of the present invention, the resu

The current techniques provide a system for monitoring a physiological parameter of a patient using microneedles that are coupled to an optical system, allowing spectroscopic measurements to be made immediately below the outer layer of the epidermis. In embodiments of the present invention, the results of the spectroscopic measurements are used to control the administration of a drug through an intravenous tube. In other embodiments, the microneedles may be coated with a drug for administration to the patient. In other embodiments, the microneedles may be mounted in a probe, wherein an actuator is used to move the needles into contact with the skin, and a drug delivery system is used to infuse the drug into the patient. A method for making needles is also provided.

대표청구항 ▼

1. An array of microneedles, comprising: one or more optically transmissive microneedles, wherein at least one of the optically transmissive microneedles is capable of transmitting light into a tissue and at least one of the optically transmissive microneedles is capable of receiving the light retur

1. An array of microneedles, comprising: one or more optically transmissive microneedles, wherein at least one of the optically transmissive microneedles is capable of transmitting light into a tissue and at least one of the optically transmissive microneedles is capable of receiving the light returning from the tissue and wherein at least one of the optically transmissive microneedles is coupled by one or more optical fibers to at least one of an optical emission device or an optical detection device. 2. The array of microneedles of claim 1 comprising one or more hollow microneedles. 3. The array of microneedles of claim 2 wherein the one or more hollow microneedles are capable of injecting a drug into a patient. 4. The array of microneedles of claim 1 wherein at least one of the microneedles comprises a continuous solid structure. 5. The array of microneedles of claim 4 wherein the microneedles comprising the respective solid structures are made from an optically transmissive material. 6. The array of microneedles of claim 1 wherein at least one of the microneedles is configured to enhance the permeability of the epidermis of a patient. 7. The array of microneedles of claim 1 wherein the array is configured to be moved by an actuator unit. 8. The array of microneedles of claim 7 wherein the actuator unit is configured to enable motion control of the array accurate to about 10 micrometers or less. 9. The array of microneedles of claim 1 wherein one or more of the microneedles are coated with a drug.