초록 ▼

A dry powder inhaler includes a chamber holding an actuator to which a powdered medicament is adhered. Air is drawn into the chamber through an inlet flow channel and exits through an outlet flow channel. The actuator oscillates in response to the air flow, dislodging powdered medicament to be entra

A dry powder inhaler includes a chamber holding an actuator to which a powdered medicament is adhered. Air is drawn into the chamber through an inlet flow channel and exits through an outlet flow channel. The actuator oscillates in response to the air flow, dislodging powdered medicament to be entrained in the air flow and delivered to the patient. A retaining member prevents the actuator from exiting the chamber. Thus, the medicament may be delivered to the patient without the use of carrier particles.

대표청구항 ▼

1. A dry powder inhaler, comprising: an inlet channel through which air enters the inhaler;a chamber that receives air from the inlet channel, the chamber containing a single actuator to which a powdered medicament is adhered, wherein the chamber has a longitudinal axis, and wherein the inlet channe

1. A dry powder inhaler, comprising: an inlet channel through which air enters the inhaler;a chamber that receives air from the inlet channel, the chamber containing a single actuator to which a powdered medicament is adhered, wherein the chamber has a longitudinal axis, and wherein the inlet channel is generally co-axial with the longitudinal axis;a retaining member disposed at an end of the chamber opposite the inlet channel, the retaining member having one or more openings sized to permit air and the powdered medicament to pass through the retaining member, and to prevent the actuator from passing through the retaining member; andan outlet channel through which air and the powdered medicament leave the inhaler to be delivered to a patient, wherein the outlet channel is generally co-axial with the longitudinal axis of the chamber;wherein the geometry of the inhaler is such that a flow profile is generated within the chamber that causes the single actuator to repeatedly oscillate generally co-axially with the longitudinal axis, thus, by virtue of the repeated oscillations, detaching the powdered medicament from the surface of the actuator to be entrained by the air and delivered to the patient through the outlet channel. 2. The dry powder inhaler of claim 1, wherein the cross sectional area of the flow path through the inhaler undergoes a step increase at an entrance to the chamber. 3. The dry powder inhaler of claim 2, wherein at the entrance to the chamber a diameter of the chamber is at least 1.5 times a diameter of the inlet channel. 4. The dry powder inhaler of claim 1, wherein the inlet channel comprises a tapered tube. 5. The dry powder inhaler of claim 1, wherein the outlet channel comprises a tube whose cross section changes along the length of the tube. 6. The dry powder inhaler of claim 1, wherein the outlet channel is comprised in a mouthpiece adapted to be placed within the mouth of the patient. 7. The dry powder inhaler of claim 1, wherein the outlet channel is comprised in a nasal adapter adapted to conform to the nostrils of the patient. 8. The dry powder inhaler of claim 1, further comprising one or more bypass channels that receive supplemental air from outside the inhaler and deliver the supplemental air to the patient without the supplemental air having passed through the chamber. 9. The dry powder inhaler of claim 1, wherein the inlet channel is a first inlet channel and the chamber is a first chamber, the dry powder inhaler further comprising a second inlet channel and a second chamber. 10. The dry powder inhaler of claim 9, wherein air and powdered medicament leaving the first and second chambers are delivered to the outlet channel. 11. The dry powder inhaler of claim 9, wherein the outlet channel is a first outlet channel, the dry powder inhaler further comprising a second outlet channel, and wherein air and powdered medicament leaving the first chamber are delivered to the first outlet channel, and air and powdered medicament leaving the second chamber are delivered to the second outlet channel. 12. The dry powder inhaler of claim 9, wherein the first and second chambers are of the same dimensions. 13. The dry powder inhaler of claim 1, wherein the dry powder inhaler is separable to permit insertion of a capsule into the chamber, the capsule containing the actuator. 14. The dry powder inhaler of claim 13, further comprising features for puncturing seals at ends of the capsule: 15. The dry powder inhaler of claim 1, wherein airflow through the inhaler is driven by inspiratory effort of the patient. 16. The dry powder inhaler of claim 1, wherein the actuator is made of expanded polystyrene. 17. The dry powder inhaler of claim 1, wherein the actuator has a density between 0.001 and 0.50 g/cm3. 18. The dry powder inhaler of claim 1, wherein the actuator has a diameter of at least 1000 microns. 19. The dry powder inhaler of claim 1, wherein the actuator has a diameter between 1000 and 6000 microns. 20. The dry powder inhaler of claim 1, wherein the actuator has a mass of between 0.1 and 5.0 milligrams. 21. The dry powder inhaler of claim 1, wherein the actuator has a mass of between 0.5 and 2.5 milligrams. 22. The dry powder inhaler of claim 1, wherein a combination of medicaments is adhered to the actuator. 23. The dry powder inhaler of claim 1, comprising a plurality of chambers disposed on a rotary element for selectively aligning any of the chambers with the outlet channel. 24. The dry powder inhaler of claim 1, wherein at an entrance to the chamber the diameter of the chamber is between 1.5 and 3.0 times the diameter of the inlet channel to facilitate the creation of a flow pattern within the chamber such that the actuator oscillates at a frequency in the range from 1 Hz to 1000 Hz. 25. A method, comprising: obtaining a dry power inhaler that includes an inlet channel, a chamber, and an outlet channel, wherein the chamber has a longitudinal axis and wherein the inlet is generally co-axial with the longitudinal axis, the chamber holding a single actuator, wherein one or more powdered medicaments are adhered to an outside surface of the actuator; andinhaling through the outlet channel that is generally co-axial with the longitudinal axis, causing air to flow into the inlet channel, through the chamber, and through the outlet channel, the flowing air also causing the actuator to repeatedly oscillate generally co-axially with the longitudinal axis to facilitate dislodgement of powdered medicament from the surface of the actuator to be entrained in the flowing air and carried through the outlet channel. 26. The method of claim 25, further comprising: separating two portions of the inhaler comprising the chamber and the outlet channel;loading the actuator into the chamber; andre-engaging the two portions of the inhaler. 27. The method of claim 25, wherein a combination of powdered medicaments is adhered to the actuator. 28. The method of claim 25, wherein the dry powder inhaler includes at least two chambers that each contain a single actuator having medicament adhered thereto, and wherein the flowing air causes each actuator to oscillate to facilitate dislodgement of powdered medicament to be inhaled. 29. The method of claim 28, wherein the at least two actuators have the same powdered medicament adhered to the actuators. 30. The method of claim 28, wherein the at least two actuators have different powdered medicaments adhered to the actuators. 31. The method of claim 25, wherein the actuator oscillates at a frequency in the range from 1 Hz to 1000 Hz. 32. The method of claim 25, wherein the actuator oscillates at a frequency in the range from 25 Hz to 150 Hz. 33. The method of claim 25, wherein at the entrance to the chamber a diameter of the chamber is between 1.5 and 3.0 times a diameter of the inlet channel. 34. A dry powder inhaler, comprising: an inlet channel through which air enters the inhaler;a chamber that receives air from the inlet channel, the chamber containing a single actuator to which a powdered medicament is adhered, wherein the chamber has a longitudinal axis, and wherein the inlet channel is generally co-axial with the longitudinal axis; andan outlet channel through which air and the powdered medicament leave the inhaler to be delivered to a patient, wherein the outlet channel is generally co-axial with the longitudinal axis;wherein the geometry of the inhaler is such that a flow profile is generated within the chamber that causes the single actuator to repeatedly oscillate generally co-axially with the longitudinal axis, thus, by virtue of the repeated oscillations, detaching the powdered medicament from the surface of the actuator to be entrained by the air and delivered to the patient through the outlet channel.