Certain aspects of the invention are generally directed to devices for withdrawing a substance from the skin and/or from beneath the skin of a subject, and/or for delivering a substance to the skin and/or to a location beneath the skin of a subject. In some embodiments, the devices may comprise one
Certain aspects of the invention are generally directed to devices for withdrawing a substance from the skin and/or from beneath the skin of a subject, and/or for delivering a substance to the skin and/or to a location beneath the skin of a subject. In some embodiments, the devices may comprise one or more skin insertion objects, such as needles or microneedles. In some cases, the device also may comprise one or more vacuum chambers. In some aspects, the device may be contained within an environment able to assist with maintenance of such pressures. For example, a package containing such an environment may also have a pressure less than atmospheric pressure, and/or the package may be molded to the device or otherwise have a shape that does not contain substantial gases that can “leak” into the device and alter the pressure of any vacuum chambers that may be contained therein.
대표청구항▼
1. An article, comprising: a receiving device for receiving blood and/or other bodily fluid from the skin and/or from beneath the skin of a subject, comprising at least one microneedle and a vacuum chamber containing therein a first reduced pressure that is less than about 50 mmHg below atmospheric
1. An article, comprising: a receiving device for receiving blood and/or other bodily fluid from the skin and/or from beneath the skin of a subject, comprising at least one microneedle and a vacuum chamber containing therein a first reduced pressure that is less than about 50 mmHg below atmospheric pressure;a package containing therein the receiving device, the package comprising a material having a permeability to O2 or N2 of less than about 2000 cm3 mm/(m2 Bar day) and having an inner surface; anda second reduced pressure between the receiving device and the inner surface of the package, wherein the second reduced pressure is less than about 50 mmHg below atmospheric pressure. 2. The article of claim 1, wherein one or more of the at least one microneedles is solid. 3. The article of claim 1, wherein at least a portion of the package is manually deformable. 4. The article of claim 1, wherein at least a portion of the package is rigid. 5. The article of claim 1, wherein the package comprises a laminate of a metal and a polymer. 6. The article of claim 5, wherein the laminate comprises aluminum foil that is laminated to the polymer. 7. The article of claim 5, wherein the polymer is polyester. 8. The article of claim 1, wherein the first reduced pressure is less than about 500 mmHg below atmospheric pressure, and the second reduced pressure is less than about 500 mmHg below atmospheric pressure. 9. The article of claim 1, wherein the pressure of the vacuum chamber and the pressure of the package are substantially equal. 10. The article of claim 1, wherein the receiving device defines therein a first volume, and the package defines therein a second volume defined externally of the receiving device, wherein the second volume is no more than about 25% of the first volume. 11. The article of claim 1, wherein the receiving device defines therein a first volume, and the package defines therein a second volume defined externally of the receiving device, wherein the second volume is at least about 50% of the first volume. 12. The article of claim 1, wherein the package contains a sterile environment. 13. The article of claim 1, wherein the package further comprises an oxygen scavenger. 14. The article of claim 13, wherein the oxygen scavenger is an oxygen scavenging film contained within the material of the package. 15. The article of claim 1, wherein the material of the package further comprises an oxygen barrier layer. 16. The article of claim 1, wherein the receiving device further comprises a device activator that, when the device activator is activated, applies the reduced pressure from the vacuum chamber to the skin of the subject to cause blood and/or other bodily fluids released from the subject due to action of the at least one microneedle to flow, from the subject, into the receiving device.
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