IPC분류정보
| 국가/구분 |
United States(US) Patent
등록
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| 국제특허분류(IPC7판) |
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| 출원번호 |
US-0041591
(2011-03-07)
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| 등록번호 |
US-8562538
(2013-10-22)
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발명자
/ 주소 |
- Osypka, Markus J.
- Bernstein, Donald P.
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| 출원인 / 주소 |
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| 대리인 / 주소 |
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| 인용정보 |
피인용 횟수 :
0 인용 특허 :
64 |
초록
▼
In order to reliably determine the left-ventricular ejection time TLVE of a heart of a subject, at least two different measuring methods are employed. This includes in any case the derivation of a first waveform related to thoracic electrical bioimpedance or bioadmittance. A second waveform can be d
In order to reliably determine the left-ventricular ejection time TLVE of a heart of a subject, at least two different measuring methods are employed. This includes in any case the derivation of a first waveform related to thoracic electrical bioimpedance or bioadmittance. A second waveform can be determined by using pulse oximetry, Doppler velocimetry, measurement of arterial blood pressure and measurement of peripheral electrical bioimpedance or bioadmittance. Depending on signal quality, the results obtained by each method are weighted and then averaged. The weighted average for left-ventricular ejection time is used as an input variable for cardiovascular monitoring methods, which determine objective measurements of cardiovascular function and performance. Such measurements include, but are not limited to, left ventricular ejection fraction, stroke volume, cardiac output, systolic time ratio, and indices of ventricular contractility.
대표청구항
▼
1. A system for determining the left-ventricular ejection time TLVE of a heart of a subject, the system comprising: a first apparatus for measuring data representing one of thoracic electrical bioimpedance and thoracic electrical bioadmittance over time;at least one second apparatus selected from th
1. A system for determining the left-ventricular ejection time TLVE of a heart of a subject, the system comprising: a first apparatus for measuring data representing one of thoracic electrical bioimpedance and thoracic electrical bioadmittance over time;at least one second apparatus selected from the group comprising:an apparatus for deriving plethysmogram data,an apparatus for deriving signal data representing the velocity of blood in an artery in the vicinity of the esophagus of the subject,an apparatus for deriving signal data representing the velocity of blood in radial artery of the subject,a first pressure sensor configured to be non-invasively attached to the subject, said first pressure sensor for measuring data representing the blood pressure in an artery of the subject,a second pressure sensor configured to be inserted into an artery of the subject, said second pressure sensor for measuring data representing the blood pressure in an artery of the subject,an apparatus for measuring data representing peripheral electrical bioimpedance, andan apparatus for measuring data representing peripheral electrical bioadmittance; anda device configured to input and derive from the data obtained by said first apparatus and said at least one second apparatus an averaged opening point of the aortic valve by averaging valve opening time-points measured by said first apparatus and said at least one second apparatus using predetermined criteria, and further configured to input and derive from the data obtained by said first apparatus and said at least one second apparatus an averaged closure point of the aortic valve by averaging valve closing time-points measured by said first apparatus and said at least one second apparatus using the predetermined criteria, and further configured to determine a value for TLVE by calculating the time interval between the averaged opening point of the aortic valve and the averaged closure point of the aortic valve. 2. The system according to claim 1, further comprising: a device communicating with said first apparatus using the predetermined criteria to independently define the opening and the closure points of the aortic valve of the subject based on the data obtained by said first apparatus, andfor each of said at least one second apparatus selected from the group, a device communicating with said at least one second apparatus using the predetermined criteria to independently define the opening and the closure points of the aortic valve of the subject based on the data obtained by said at least one second apparatus. 3. A system according to claim 2, wherein said device adapted to input, derive, and determine, said device communicating with said first apparatus, and said device communicating with said at least one second apparatus are formed as a unit. 4. The system according to claim 1, further comprising at least one of a display for displaying the value of TLVE determined by said system and an output line for electronically outputting the value of TLVE determined by said system. 5. The system according to claim 1, wherein the predetermined criteria includes weighted values for valve opening time-points and valve closing time-points. 6. The system according to claim 1, wherein said first apparatus comprises: at least two electrodes attached to the subject; an alternating current (AC) source connected to said at least two electrodes and applied to the subject; a voltmeter adapted to measure a voltage drop across the subject. 7. The system according to claim 6, wherein said electrodes are adapted to attach to the thorax of the subject. 8. The system according to claim 6, further comprising a catheter adapted to be inserted in the esophagus of the subject, wherein said electrodes are placed on said catheter.
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