IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0510548
(2009-07-28)
|
등록번호 |
US-8562667
(2013-10-22)
|
발명자
/ 주소 |
|
출원인 / 주소 |
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
12 인용 특허 :
82 |
초록
▼
The present invention is directed to aneurysm treatment devices which are capable of being delivered to the situs of a vascular aneurysm through a catheter. The treatment devices comprise, in general, a body member formed by at least one support member and a reactive material selectively applied to
The present invention is directed to aneurysm treatment devices which are capable of being delivered to the situs of a vascular aneurysm through a catheter. The treatment devices comprise, in general, a body member formed by at least one support member and a reactive material selectively applied to the at least one support member. The body member provide support mechanical support to a weakened or otherwise incompetent blood vessel. The reactive material is capable of restricting or occluding blood flow to the aneurysm, without substantially affecting blood flow through the blood vessel.
대표청구항
▼
1. An apparatus that is implantable in the vasculature of a subject to treat a vascular aneurysm, said apparatus, comprising: at least one expandable stent having fenestrations, said expandable stent comprising a substantially cylindrical body member located between first and second ends, said cylin
1. An apparatus that is implantable in the vasculature of a subject to treat a vascular aneurysm, said apparatus, comprising: at least one expandable stent having fenestrations, said expandable stent comprising a substantially cylindrical body member located between first and second ends, said cylindrical body member having at least one circumferential element between said first and said second ends defining an internal lumen in communication with said first and second ends;wherein said at least one expandable stent is expandable between a first diameter D and a second diameter D′ wherein D′ is larger than D; anda reactive material applied to some but not all of the stent, said reactive material having a first state of protonation prior to implantation in the body and undergoing a change to a second state of protonation after implantation in the body, said change in the state of protonation resulting in expansion of the reactive material and resulting in a decrease in the size of some of the fenestrations such that blood flow through those fenestrations is lessened. 2. The apparatus of claim 1 wherein said reactive material is an expandable polymer. 3. The apparatus of claim 1 wherein said reactive material is a hydrogel. 4. The apparatus of claim 1 wherein said reactive material is responsive to pH. 5. The apparatus of claim 1 wherein said reactive material is integrally formed with said at least one expandable stent. 6. The apparatus of claim 1 wherein said reactive material has a non-reacted volume of V and a reacted volume of V′, wherein V′ is larger than V. 7. The apparatus of claim 6 wherein said reactive material is capable of obtaining the reacted volume V′ in the presence of a physiological pH of about 7.4. 8. The apparatus of claim 1 wherein said expanded stent comprises a radially and axially flexible fenestrated bifurcated stent having a bifurcated body member located between a first end, a second end, and a third end, said bifurcated body defining an internal lumen in communication with said first, second, and third ends. 9. The apparatus of claim 1 where said at least one expandable stent is capable of being delivered to a situs in vivo and controllably released from a delivery device, said delivery device selected from the group consisting of catheters, micro-catheters, balloon catheters, expandable catheters, guidewires, wires, and elongated bodies. 10. The apparatus of claim 1 where said at least one expandable stent is capable of being delivered to a situs in vivo and controllably released from a delivery device using a controllable release mechanism selected from the group consisting of mechanical, electrolytic, electro-mechanical, thermal, hydraulic, and shape-memory release mechanisms. 11. The apparatus of claim 1 wherein said expandable stent is manufactured from at least one biologically-compatible material selected from the group consisting of platinum, gold, tantalum, titanium, stainless steel, tungsten, Nitinol, shape memory alloys, polyurethane, polytetrafluoroethylene, polyvinyl alcohol, polyester, silicone, or acrylic. 12. The apparatus of claim 1 wherein said expandable stent comprises radio-opaque materials. 13. The apparatus of claim 1 wherein said expandable stent comprises echo-genic materials. 14. The apparatus of claim 1 wherein said expandable stent comprises a radially and axially expanding helical stent. 15. The apparatus of claim 1 wherein said expandable stent comprises a cylindrical reticulated body. 16. The apparatus of claim 1 wherein said expandable stent comprises a helical cylindrical member. 17. An apparatus for treating vascular aneurysms, comprising: at least one expandable, woven stent having fenestrations, said expandable stent further having a cylindrical body member located between a first and second end, said cylindrical body member further defining an internal lumen in communication with said first and second ends, wherein blood is capable of flowing through said internal lumen and flowing radially through said fenestrations into the aneurysm;wherein said at least one expandable stent is expandable between a first D and a second D′ wherein D′ is larger than D; anda pH reactive material interwoven with said at least one expandable, woven stent, said pH reactive material located along some but not all of said fenestrations, said pH reactive material having a non-reacted state and a reacted state, wherein said pH reactive material in said reacted state is capable of increasing the resistance to blood flow through not all of said fenestrations. 18. An apparatus that is implantable in the vasculature of a subject to treat a vascular aneurysm, said apparatus comprising: a helical stent that is expandable from a first diameter D to a second diameter D′, wherein D′ is larger than D, said helical stent having an external surface and an internal lumen when expanded to its second diameter D′ and there being at least one opening through said external surface; anda reactive material selectively applied to some but not all of said helical stent, said reactive material having a first state of protonation prior to implantation in the body and undergoing a change to a second state of protonation after implantation in the body, said change in the state of protonation giving rise to expansion of the reactive material and resulting in a decrease in the size of at least one opening such that blood flow through said at least one opening is lessened. 19. An apparatus that is implantable in the vasculature of a subject to treat a vascular aneurysm, said apparatus, comprising: an expandable reticulated stent having a substantially cylindrical body member located between a first and second end, said cylindrical body member having at least one circumferential element between said first and said second end defining an internal lumen in communication with said first and second ends, wherein blood is capable of flowing through said internal lumen and radially out of the Internal lumen through fenestrations and into the aneurysm;said cylindrical body member formed by a plurality of support members capable of supporting vascular tissue;said cylindrical body member having a first diameter D and a second diameter D′, wherein D′ is larger than D; anda reactive material selectively applied to some but not all of said support members, said reactive material having a first state of protonation prior to implantation in the body and undergoing a change to a second state of protonation after implantation in the body, said change in the state of protonation giving rise to expansion of the reactive material and resulting in a decrease in the size of some of the fenestrations such that blood flow through those fenestrations is lessened. 20. An apparatus for treating vascular aneurysms, comprising: at least one expandable stent having fenestrations, said expandable stent comprising a substantially cylindrical body member located between a first and second end, said cylindrical body member further defining an internal lumen in communication with said first and second ends, wherein blood is capable of flowing through said internal lumen and flowing radially through said fenestrations into the aneurysm;wherein said at least one expandable stent is expandable between a first diameter D and a second diameter D′, wherein D′ is larger than D; anda stimulus-expandable hydrogel selectively applied to the stent adjacent to some but not all of said fenestrations, said stimulus-expandable hydrogel having a first state of protonation prior to implantation in the body and undergoing a change to a second state of protonation after implantation in the body, said change in the state of protonation of giving rise to expansion of the reactive material and resultant lessening the size of some of the adjacent fenestrations such that blood flow through those fenestrations is lessened. 21. The apparatus of claim 20 wherein said stimulus-expandable hydrogel is responsive to pH. 22. The apparatus of claim 20 wherein said stimulus-expandable hydrogel is capable of obtaining an increased volume in said reacted state in the presence of a physiological pH of about 7.4. 23. The apparatus of claim 20 wherein said stimulus-expandable hydrogel comprises at least an ethylenically unsaturated monomer with an ionizable functional group. 24. The apparatus of claim 23 wherein said ionizable functional group comprises an amine. 25. The apparatus of claim 23 wherein said ionizable functional group comprises carboxylic acid.
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