[특허]Treatment composition comprising physically disrupted tooth pulp and non-cultured stem cells

Treatment composition comprising physically disrupted tooth pulp and non-cultured stem cells 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	C12N-005/00 A01N-063/00
출원번호	US-0772286 (2010-05-03)
등록번호	US-8562969 (2013-10-22)
발명자 / 주소	Wasielewski, Ray C.
출원인 / 주소	Wasielewski, Ray C.
대리인 / 주소	Wood, Herron & Evans, LLP
인용정보	피인용 횟수 : 0 인용 특허 : 24

초록 ▼

A medical implant comprising in components from a tooth and stem cells harvested from at least one tooth. Tooth stem cells may be harvested from the dental pulp of mammalian teeth, such as unerupted third molars in humans. After the stem cells are removed and isolated from the other teeth tissue, the hard tooth may be ground into a base material for the manufacture of a porous matrix into which the tooth stem cells can be added. Additionally, soft tissue from the harvested tooth may be used as a carrier scaffold for soft tissue applications such as meniscal or cartilage repair.

대표청구항 ▼

1. A medical treatment composition comprising physically disrupted tooth pulp including a plurality of non-cultured stem cells, wherein the composition is in a form for injection or depot. 2. The medical treatment composition of claim 1, wherein the physically disrupted tooth pulp is chosen from a diced tooth pulp, a minced tooth pulp, and combinations thereof. 3. The medical treatment composition of claim 1, wherein the physically disrupted tooth pulp is a sterilized, physically disrupted tooth pulp, and wherein the sterilized, physically disrupted tooth pulp includes a plurality of stem cells that are living. 4. The medical treatment composition of claim 1, wherein the physically disrupted tooth pulp including a plurality of stem cells includes: one or more endogenous growth factors expressed from endogenous genes of cells of the tooth pulp, orone or more exogenous growth factors. 5. The medical treatment composition of claim 4, wherein the one or more endogenous or exogenous growth factors are chosen from transforming growth factor beta, insulin like growth factor I, insulin like growth factor II, platelet-derived growth factor, fibroblast growth factor, and bone morphogenetic proteins. 6. The medical treatment composition of claim 1, wherein the plurality of stem cells includes pluripotent stem cells. 7. The medical treatment composition of claim 1, wherein the physically disrupted tooth pulp is non-enzyme-digested. 8. A medical treatment composition comprising physically disrupted non-enzyme-digested tooth pulp including a plurality of stem cells, wherein the composition is in a form for injection or depot. 9. A medical treatment composition comprising: (a) physically disrupted tooth pulp including a plurality of non-cultured stem cells, wherein the physically disrupted tooth pulp including a plurality of stem cells includes: (i) one or more endogenous growth factors expressed from endogenous genes of cells of the tooth pulp, or(ii) one or more exogenous growth factors; and(b) a plurality of ground mammalian tooth particles, wherein at least a portion of the plurality of ground mammalian tooth particles are derived from the same mammalian tooth from which at least a portion of the plurality of stem cells are derived. 10. A medical treatment composition comprising: (a) physically disrupted tooth pulp including a plurality of non-cultured stem cells, wherein the physically disrupted tooth pulp including a plurality of stem cells includes: (i) one or more endogenous growth factors expressed from endogenous genes of cells of the tooth pulp, or(ii) one or more exogenous growth factors; and(b) a plurality of ground mammalian tooth particles, wherein at least a portion of the plurality of ground mammalian tooth particles are derived from a different mammalian tooth from which at least a portion of the plurality of stem cells are derived. 11. A medical treatment composition comprising physically disrupted tooth pulp including a plurality of non-cultured stem cells, wherein the composition is in a form for topical application.

이 특허에 인용된 특허 (24)

Shi,Songtao; Gronthos,Stan; Robey,Pamela Gehron, Adult human dental pulp stem cells in vitro and in vivo.
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Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Isaacs, Dickon; Steibel, Dennis; Fraser, Richard; Harris, Stanley; Schein, Douglas, Apparatus and method for maintaining and/or restoring viability of organs.
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Caplan Arnold I. ; Fink David J. ; Young Randell G., Biomatrix for soft tissue regeneration.
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Kadiyala Sudhakar ; Caplan Arnold I. ; Fink David J. ; Young Randall G., Biomatrix for soft tissue regeneration using mesenchymal stem cells.
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Sharpe,Paul Thomas; Leek,Michael David; Kemp,Paul David; Campbell,Ewan James, Bone regeneration.
상세보기
Mooney David J. ; Rutherford Robert B., Engineering oral tissues.
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Sharpe, Paul Thomas, Generating teeth from bone marrow cells.
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Brockbank Kelvin G. M. (Marietta GA), Method for cryopreserving musculoskeletal tissues.
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Hiatt Andrew C. ; Ma Julian K.-C.,GBX ; Lehner Thomas,GBX ; Mostov Keith E., Method for producing immunoglobulins containing protection proteins in plants and their use.
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Brockbank,Kelvin G. M.; Campbell,Lia H.; Ratcliff,Kelly M.; Sarver,Kristy A., Method for treatment of cellular materials with sugars prior to preservation.
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Khirabadi Bijan S. ; Song Ying C. ; Brockbank Kelvin G. M., Method of cryopreservation of blood vessels by vitrification.
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Khirabadi, Bijan S.; Song, Ying C.; Brockbank, Kelvin G. M., Method of cryopreservation of tissues by vitrification.
상세보기
Khirabadi,Bijan S.; Song,Ying C.; Brockbank,Kelvin G. M., Method of cryopreservation of tissues by vitrification.
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Yelick, Pamela C.; Bartlett, John D.; Vacanti, Joseph P.; Olsen, Bjorn R.; Stashenko, Phillip, Methods and compositions for culturing a biological tooth.
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Phillips,Catherine, Methods and compositions for directing cells to target organs.
상세보기
Phillips, Catherine A., Methods and compositions for regenerating tissue.
상세보기
Yamanaka, Shinya; Takahashi, Kazutoshi; Okita, Keisuke, Nuclear reprogramming factor.
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Yamanaka, Shinya; Takahashi, Kazutoshi, Oct3/4, Klf4, c-Myc and Sox2 produce induced pluripotent stem cells.
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Benedict, James John; Brewster, Greg Allen; Freeman, Donald Barclay, Pliable medical device and method of use.
상세보기
Brockbank Kelvin G. M., Polyethylene glycol and glutathione composition and method for the treatment of blood vessels prior to cryopreservation.
상세보기
Carpenter John F. (Marietta GA) Brockbank Kelvin G. M. (Marietta GA), Process of revitalizing cells prior to cryopreservation.
상세보기
Sramek, Roger Anton; Javid, Bahram, Stem cell and dental pulp harvesting method and apparatus.
상세보기
Carinci, Francesco; D'Aquino, Riccardo; De Rosa, Alfredo; Graziano, Antonio; Laino, Gregorio; Papaccio, Gianpaolo, Stem cells obtained from pulp of deciduous or permanent teeth and of dental germ, able to produce human bone tissue.
상세보기
Campbell, Lia Hanson; Brockbank, Kelvin G. M.; Taylor, Michael J., Two stage method for thawing cryopreserved cells.
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