Compositions and methods for administering compartmentalized frozen particles
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-051/00
A61K-009/14
A61K-009/00
출원번호
US-0383829
(2009-03-27)
등록번호
US-8563012
(2013-10-22)
발명자
/ 주소
Boyden, Edward S.
Cook, Daniel B.
Hyde, Roderick A.
Leuthardt, Eric C.
Myhrvold, Nathan P.
Sweeney, Elizabeth A.
Wood, Jr., Lowell L.
출원인 / 주소
The Invention Science Fund I, LLC
인용정보
피인용 횟수 :
1인용 특허 :
128
초록▼
Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particula
Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.
대표청구항▼
1. A frozen particle composition, comprising: a frozen carbon dioxide particle approximately one micrometer or less, and defining at least one cavity;the at least one cavity containing at least one agent including a vitamin, vaccine or cytokine; andwherein the frozen carbon dioxide particle is coate
1. A frozen particle composition, comprising: a frozen carbon dioxide particle approximately one micrometer or less, and defining at least one cavity;the at least one cavity containing at least one agent including a vitamin, vaccine or cytokine; andwherein the frozen carbon dioxide particle is coated with at least one biological remodeling agent including one or more of calcium phosphate, albumin, fibrin, thrombin, glutaraldehyde-crosslinked pericardium, hyaluronic acid, hydroxyapatite, keratin, ligament, nitinol, polyethylene, polylethylene glycol, polyethylene glycol diacrylate, polyethylene terephthalate fiber, polyglycol, polylactate, polytetrafluoroethylene, fibrinogen, hyaluronate, chitin, chitosan, methylcellulose, alginate, hyaluronic acid, agarose, cellulose, polyaldehyde gluronate, Factor XIII, Factor XII, silk, nylon, collagen, elastin, silicone, polyurethane, ceramic powder, pectin, wax, glycosaminoglycan, poly(α-hydroxyacid), selectin, or glutaraldehyde. 2. The frozen particle composition of claim 1, further including at least one of nitrogen, helium, neon, xenon, krypton, chlorine, bromine, carbon dioxide, air, oxygen, or argon. 3. The frozen particle composition of claim 1, wherein at least one cavity is configured to physically or chemically separate the at least one agent from at least one other cavity of the frozen particle. 4. The frozen particle composition of claim 1, wherein at least one cavity is configured to physically or chemically separate from at least one other cavity of the frozen particle during administration. 5. The frozen particle composition of claim 1, wherein the at least one cavity is an inner core cavity of at least one frozen particle. 6. The frozen particle composition of claim 1, wherein the at least one cavity includes an inner core cavity and wherein the at least one agent is at least one of a liquid or gas. 7. The frozen particle composition of claim 1, wherein the at least one cavity has a higher concentration of the at least one agent than any other cavity. 8. The frozen particle composition of claim 1, wherein the at least one agent includes one or more of a pro-drug or precursor compound. 9. The frozen particle composition of claim 1, wherein the at least one agent includes one or more time-release or extended-release formulations. 10. The frozen particle composition of claim 1, further including one or more of an adhesive agent, reinforcement agent, abrasive, or explosive material. 11. The frozen particle composition of claim 1, further including a plurality of frozen particles that are approximately uniform in size, shape, weight, or density. 12. The frozen particle composition of claim 1, further including at least one of a nanoparticle, detection material, sensor, micro-syringe, or circuit. 13. The frozen particle composition of claim 12, wherein the detection material is located in at least one cavity of at least one frozen particle composition. 14. The frozen particle composition of claim 12, wherein the detection material includes at least one electronic identification device. 15. The frozen particle composition of claim 14, wherein the at least one electronic identification device includes at least one radio frequency identification device. 16. The frozen particle composition of claim 12, wherein the detection material includes at least one radioactive element. 17. The frozen particle composition of claim 12, wherein the detection material includes at least one luminescent, colorimetric or odorous substance. 18. The frozen particle composition of claim 12, wherein the at least one colorimetric substance includes one or more of an inorganic, organic, biological, natural, artificial, or synthetic substance. 19. The frozen particle composition of claim 12, wherein the at least one detection material includes one or more of a dye, pigment, luminescent substance, fluorescent substance, or phosphorescent substance. 20. The frozen particle composition of claim 12, wherein the detection material includes at least one of a diamagnetic particle, ferromagnetic particle, paramagnetic particle, super paramagnetic contrast agent, or other magnetic particle. 21. The frozen particle composition of claim 1, formulated to be administered to at least one substrate. 22. The frozen particle composition of claim 21, wherein the at least one substrate includes one or more of a cell, tissue, organ, structure, or device. 23. The frozen particle composition of claim 1, further including one or more agents located outside of the at least one cavity.
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