IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0030958
(2011-02-18)
|
등록번호 |
US-8568627
(2013-10-29)
|
발명자
/ 주소 |
|
출원인 / 주소 |
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
2 인용 특허 :
69 |
초록
▼
A lens for placement in a human eye, such as intraocular lens, has at least some of its optical properties formed with a laser. The laser forms modified loci in the lens when the modified loci have a different refractive index than the refractive index of the material before modification. Different
A lens for placement in a human eye, such as intraocular lens, has at least some of its optical properties formed with a laser. The laser forms modified loci in the lens when the modified loci have a different refractive index than the refractive index of the material before modification. Different patterns of modified loci can provide selected dioptic power, toric adjustment, and/or aspheric adjustment provided. Preferably both the anterior and posterior surfaces of the lens are planar for ease of placement in the human eye.
대표청구항
▼
1. A method for modifying at least one optical property of a lens in situ in a human eye, the lens comprising a body formed of an optical material and having an anterior surface, a posterior surface and an optical axis, the method comprising: forming a contiguous three-dimensional patterned microstr
1. A method for modifying at least one optical property of a lens in situ in a human eye, the lens comprising a body formed of an optical material and having an anterior surface, a posterior surface and an optical axis, the method comprising: forming a contiguous three-dimensional patterned microstructure in the body by modifying a plurality of contiguous loci in a layer of the body by optically distributing a focused laser beam on each locus causing a nonlinear absorption of photons in the optical material of each modified locus resulting in a change to the refractive index of the optical material in each locus,wherein the contiguous three-dimensional patterned microstructure comprises a phase shifting optical structure that modifies the at least one optical property of the lens, said phase shifting optical structure comprising a plurality of full-wave, phase-wrapped zones that compensate for optical path length differences within an array of neighboring light rays. 2. The method of claim 1, wherein the contiguous three-dimensional patterned microstructure formed in the forming step comprises a refractive structure. 3. The method of claim 1, wherein the layer is planar. 4. The method of claim 2, wherein the layer is substantially perpendicular to the optical axis. 5. The method of claim 1, wherein each modified locus being right cylindrically shaped and having an axis substantially parallel to the optical axis and an axial depth of at least 5 μm. 6. The method of claim 1, wherein the plurality of contiguous loci includes at least 1,000,000 modified loci in the layer. 7. The method of claim 1, wherein the at least one optical property comprises adjusting the diopter power of the lens by at least plus or minus 0.5. 8. The method of claim 1, wherein the forming step modifies at least some of the loci to have an optical path length of from 0.1 to about 1 wavelength greater than the optical path length of a non-modified locus, wherein the wavelength is with respect to light of wavelength of 555 nm. 9. The method of claim 1, wherein at least some of the modified loci are configured in a substantially circular pattern around an optical axis of the lens. 10. The method of claim 1, wherein after the forming step there are sufficient modified loci in the contiguous patterned microstructure that at least 90% of light projected onto the anterior surface in a direction generally parallel to an optical axis of the lens passes through at least one modified locus. 11. The method of claim 1, wherein after the forming step each modified locus has an axial depth of from 5 to 50 μm. 12. The method of claim 1, wherein after the forming step the modified loci have axial depths varying from 5 to 50 μm. 13. The method of claim 1, wherein each locus modified during the forming step has from 1 to 10 sites, the sites being arranged in an axial direction, each site being formed by a single burst of the focused laser beam. 14. The method of claim 1, wherein the contiguous three-dimensional patterned microstructure formed in the forming step comprises an annular ring pattern. 15. The method of claim 1, wherein the layer is approximately 50 μm thick. 16. The method of claim 1, wherein the lens is an intraocular lens. 17. The method of claim 1, wherein the intraocular lens is positioned in the posterior chamber of the eye. 18. The method of claim 1, wherein the lens is a contact lens. 19. The method of claim 1, wherein the lens is the cornea. 20. The method of claim 1, wherein the lens is a natural crystalline lens. 21. The method of claim 1, wherein the at least one optical property comprises modifying the diopter power of the lens. 22. The method of claim 1, wherein the laser beam has a wavelength and the optical material comprises a polymeric matrix that includes an absorber for light of the laser beam wavelength. 23. The method of claim 22 wherein the optical material includes absorber of at least 0.01% by weight. 24. The method of claim 1, wherein the laser has a wavelength and the method further comprises selecting a lens formed of a polymeric matrix doped with an absorber for light of the laser beam's wavelength. 25. A method for modifying a lens in situ in a human eye, the lens comprising a disc with an anterior surface and a posterior surface, the method comprising the step of forming a contiguous three-dimensional patterned microstructure in a layer of the disc by modifying the index of refraction of a plurality of contiguous loci in the layer of the disc, wherein the plurality of loci includes at least 1,000,000 modified loci in the layer, each modified locus having an axial depth of no more than about 50 μm,wherein the contiguous three-dimensional patterned microstructure constitutes a phase shifting optical structure that modifies an optical property of the lens, said phase shifting optical structure comprising a plurality of full-wave, phase-wrapped zones that compensate for optical path length differences within an array of neighboring light rays. 26. The method of claim 25 wherein the layer is aligned with a plane substantially perpendicular to an optical axis of the disc. 27. The method of claim 25 wherein the layer is closer to the anterior surface than the posterior surface. 28. The method of claim 1, wherein said phase shifting optical structure generates a spherical focusing effect. 29. The method of claim 1, wherein said phase shifting optical structure generates an aspherical focusing effect. 30. The method of claim 1, wherein said phase shifting optical structure includes a defocusing meridian to accommodate for astigmatism. 31. The method of claim 1, wherein by compensating for optical path length differences within said array of neighboring light rays, contiguous individual light beams are in phase with each other. 32. The method of claim 1, further comprising: modifying a second plurality of loci in a second layer of the body by focusing said laser beam on each locus in said second plurality of loci causing a nonlinear absorption of photons in the optical material of each modified locus in said second plurality of loci resulting in a change to the refractive index of the material in each locus in said second plurality of loci;wherein the layer and second layer are spaced apart from one another. 33. The method of claim 32, wherein step of modifying said second plurality of loci in said second layer of the body comprises forming a second contiguous patterned microstructure using a modulo 2π phase wrapping technique, wherein said second contiguous patterned microstructure comprises a phase shifting optical structure having a plurality of full-wave phase-wrapped zones that compensate for optical path length differences within an array of neighboring light rays. 34. The method of claim 1, wherein the focusing step includes distributing the focused laser beam on each locus for a predetermined amount of time. 35. The method of claim 34, wherein the change to the refractive index of the material in each modified locus correlates to the total energy to which each modified locus is exposed. 36. The method of claim 34, wherein the predetermined amount of time is constant for each modified locus in the patterned microstructure. 37. The method of claim 34, wherein the predetermined amount of time is variable for the modified loci in the patterned microstructure. 38. The method of claim 1, wherein the step of optically distributing the focused laser beam includes using an optical scanner. 39. The method of claim 1, wherein the focused laser beam is distributed in a raster-scan pattern. 40. The method of claim 1, wherein the focused laser beam is distributed in a flying spot-scan pattern. 41. The method of claim 1, wherein said laser beam is a pulsed laser beam and wherein said method further comprises controlling the pulse rate of the pulsed laser beam. 42. The method of claim 41, wherein each locus is modified with a predetermined number of laser bursts, each laser burst comprising a predetermined number of laser pulses. 43. The method of claim 42, wherein the predetermined number of laser bursts is variable from a first locus to a second locus. 44. The method of claim 41, wherein each locus is modified with a predetermined number of laser bursts at a plurality of different focal depths in the locus. 45. The method of claim 44, wherein the predetermined number of laser bursts is variable from a first focal depth to a second focal depth. 46. The method of claim 25, wherein said phase shifting optical structure generates a spherical focusing effect. 47. The method of claim 25, wherein said phase shifting optical structure generates an aspherical focusing effect. 48. The method of claim 25, wherein said phase shifting optical structure includes a defocusing meridian to accommodate for astigmatism. 49. The method of claim 25, wherein by compensating for optical path length differences within said array of neighboring light rays, contiguous individual light beams are in phase with each other. 50. The method of claim 25, further comprising: modifying the index of refraction of a second plurality of loci in a second layer of the body, wherein the second plurality of loci includes at least 1,000,000 modified loci in the second layer, each modified locus in the second layer having an axial depth of no more than about 50 μm,wherein the layer and second layer are spaced apart from one another. 51. The method of claim 45 wherein step of modifying said second plurality of loci in said second layer of the body comprises forming a second contiguous patterned microstructure using a modulo 2π phase wrapping technique, wherein said second contiguous patterned microstructure comprises a phase shifting optical structure having a plurality of full-wave phase-wrapped zones that compensate for optical path length differences within an array of neighboring light rays. 52. The method of claim 25, wherein the index of refraction of each locus is modified with a predetermined number of focused laser bursts, each laser burst comprising a predetermined number of laser pulses. 53. The method of claim 52, wherein the predetermined number of focused laser bursts is variable from a first locus to a second locus. 54. The method of claim 25, wherein each locus is modified with a predetermined number of focused laser bursts at a plurality of different focal depths in the locus. 55. The method of claim 54, wherein the predetermined number of laser bursts is variable from a first focal depth to a second focal depth. 56. A method for modifying at least one optical property of a lens in situ in a human eye, the lens comprising a body formed of an optical material and having an anterior surface, a posterior surface and an optical axis, the method comprising: i) emitting laser beams; andii) using a) at least one scanner to distribute the laser beams, b) a modulator, which controls the frequency of the laser beams, and c) a focusing lens to distribute the laser beams;iii) the laser beams, which cause a nonlinear absorption of photons in the optical material, are focused on a plurality of contiguous loci in a layer of the optical material; andiv) forming a predetermined contiguous three-dimensional patterned refractive microstructure in the body of the optical material;wherein the contiguous three-dimensional patterned refractive microstructure comprises a phase shifting structure which utilizes a plurality of zones to shift the phase of light rays to compensate for optical path length differences within an array of neighboring light rays. 57. The method of claim 56, wherein each modified locus is right cylindrically shaped and having an axis substantially parallel to the optical axis and an axial depth of at least 5 μm. 58. The method of claim 56, wherein the plurality of contiguous loci includes at least 1,000,000 modified loci. 59. The method of claim 56, wherein the at least one optical property comprises adjusting the diopter power of the lens by at least plus or minus 0.5. 60. The method of claim 56, wherein at least some of the loci to have an optical path length of from 0.1 to about 1 wavelength greater than the optical path length of a non-modified locus, wherein the wavelength is with respect to light of wavelength of 555 nm. 61. The method of claim 56, wherein at least some of the modified loci are configured in a substantially circular pattern around an optical axis of the lens. 62. The method of claim 56, wherein after the forming step there are sufficient modified loci in the contiguous patterned microstructure that at least 90% of light projected onto the anterior surface in a direction generally parallel to an optical axis of the lens passes through at least one modified locus. 63. The method of claim 56, wherein each modified locus has an axial depth of from 5 to 50 μm. 64. The method of claim 56, wherein the modified loci have axial depths varying from 5 to 50 μm. 65. The method of claim 56, wherein each modified locus m has from 1 to 10 sites, the sites being arranged in an axial direction, each site being formed by a single burst of the focused laser beams. 66. The method of claim 56, wherein the contiguous three-dimensional patterned microstructure formed in the forming step comprises an annular ring pattern. 67. The method of claim 56, wherein the lens is an intraocular lens. 68. The method of claim 56, wherein the intraocular lens is positioned in the posterior chamber of the eye. 69. The method of claim 56, wherein the lens is a contact lens. 70. The method of claim 56, wherein the lens is the cornea. 71. The method of claim 56, wherein the lens is a natural crystalline lens. 72. The method of claim 56, wherein the at least one optical property comprises modifying the diopter power of the lens. 73. The method of claim 56, wherein the laser beams have a wavelength and the optical material comprises a polymeric matrix that includes an absorber for light of the laser beams' wavelength. 74. The method of claim 73 wherein the optical material includes absorber of at least 0.01% by weight. 75. The method of claim 56, wherein the laser has a wavelength and the method further comprises selecting a lens formed of a polymeric matrix doped with an absorber for light of the laser beams' wavelength. 76. The method of claim 56, wherein the distributing step includes directing the focused laser beams on each locus for a predetermined amount of time. 77. The method of claim 56, wherein the change to the refractive index of the material in each modified locus correlates to the amount of energy applied to the focal spot in the locus. 78. The method of claim 56, wherein the predetermined amount of time is constant for each modified locus in the patterned microstructure. 79. The method of claim 56, wherein the predetermined amount of time is variable for the modified loci in the patterned microstructure. 80. The method of claim 56, wherein the focused laser beams are distributed in a raster-scan pattern. 81. The method of claim 56, wherein the focused laser beam are distributed in a flying spot-scan pattern. 82. The method of claim 56, wherein said laser beams are pulsed laser beams and wherein said method further comprises controlling the pulse rate of the laser beams. 83. The method of claim 56, wherein each locus is modified with a predetermined number of laser bursts, each laser burst comprising a predetermined number of laser pulses. 84. The method of claim 83, wherein the predetermined number of laser bursts is variable from a first locus to a second locus. 85. The method of claim 56, wherein each locus is modified with a predetermined number of laser bursts at a plurality of different focal depths in the optical material, each laser burst comprising a predetermined number of laser pulses. 86. The method of claim 85, wherein the predetermined number of laser bursts is variable from a first focal depth to a second focal depth.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.