IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0564874
(2012-08-02)
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등록번호 |
US-8568769
(2013-10-29)
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발명자
/ 주소 |
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출원인 / 주소 |
- The Regents of The University of Michigan
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대리인 / 주소 |
Dierker & Associates, P.C.
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인용정보 |
피인용 횟수 :
0 인용 특허 :
9 |
초록
▼
Porous materials and methods for forming them are disclosed. One method for immobilizing micro-particles and/or nano-particles onto internal pore surfaces and/or external pore surfaces of porous materials includes suspending the micro-particles and/or nano-particles in a liquid adapted to swell, sof
Porous materials and methods for forming them are disclosed. One method for immobilizing micro-particles and/or nano-particles onto internal pore surfaces and/or external pore surfaces of porous materials includes suspending the micro-particles and/or nano-particles in a liquid adapted to swell, soften, and/or deform either the porous materials and/or the particles, thereby forming a liquid-particle suspension. The method further includes adding the suspension to the porous materials; and removing the liquid, thereby forming the porous materials having the micro-particles and/or nano-particles immobilized on the internal pore surfaces and/or the external pore surfaces.
대표청구항
▼
1. A method for immobilizing at least one of micro-particles or nano-particles onto at least one of internal pore surfaces or external pore surfaces of porous materials, the method comprising: suspending the at least one of micro-particles or nano-particles in a non-solvent of both the porous materi
1. A method for immobilizing at least one of micro-particles or nano-particles onto at least one of internal pore surfaces or external pore surfaces of porous materials, the method comprising: suspending the at least one of micro-particles or nano-particles in a non-solvent of both the porous materials and the at least one of micro-particles or nano-particles, thereby forming a non-solvent-particle suspension;and then adding the suspension to the porous materials;removing the non-solvent to form the porous materials having the at least one of micro-particles or nano-particles loosely adhered on at least one of the internal pore surfaces or the external pore surfaces;adding a liquid adapted to perform at least one of swelling, deforming, or slightly dissolving of at least one of the porous materials or the at least one of micro-particles or nano-particles to the porous materials having the at least one of micro-particles or nano-particles loosely adhered thereon, thereby at least one of swelling, deforming or slightly dissolving at least one of the porous materials or the at least one of micro-particles or nano-particles and strongly adhering the at least one of micro-particles or nano-particles on the at least one of the internal pore surfaces or the external pore surfaces; andremoving the liquid, thereby forming the porous materials having the at least one of micro-particles or nano-particles immobilized on the at least one of the internal pore surfaces or the external pore surfaces. 2. The method as defined in claim 1 wherein the at least one of the micro-particles or the nano-particles is selected from natural materials, synthetic materials, organic materials, inorganic materials, metallic materials, composites thereof, and combinations thereof. 3. The method as defined in claim 1 wherein the at least one of the micro-particles or nano-particles is a controlled release particle having an agent embedded therein. 4. The method as defined in claim 3 wherein the agent is selected from proteins, hormones, DNA, RNA, nutrients, drugs, biologically regulating agents, and combinations thereof. 5. The method as defined in claim 3 wherein, prior to suspending the at least one of the micro-particles or nano-particles, the method further comprises varying at least one property of the at least one of the micro-particles or nano-particles, thereby altering at least one release characteristic of the agent. 6. The method as defined in claim 3 wherein the at least one of the micro-particles or nano-particles is selected from the group consisting of poly(lactide-co-glycolide), poly(L-lactic acid), poly(D,L-lactic acid), polyglycolic acid, polyanhydrides, poly(ortho ethers), poly(ε-caprolactone), poly(hydroxy butyrate), poly(propylene fumarate), polyphosphoesters, polyphosphazenes, collagen, gelatin, and carbohydrates. 7. The method as defined in claim 1 wherein removing the liquid is accomplished by at least one of freeze-drying, vacuum drying, evaporation, or exchange with a non-solvent of the particles and the porous material. 8. Porous materials formed by the method of claim 1. 9. The method as defined in claim 1 wherein the non-solvent is selected from the group consisting of hexane or a mixture of ethanol and water, and wherein the liquid is a mixture of hexane and tetrahydrofuran, a mixture of ethanol and acetone, or a mixture of isopropanol and acetone. 10. A method for immobilizing at least one of micro-particles or nano-particles onto at least one of internal pore surfaces or external pore surfaces of porous materials, the method comprising: suspending the at least one of micro-particles or nano-particles in a liquid adapted to at least one of swell, soften, and deform but not dissolve at least one of the porous materials and the at least one of micro-particles or nano-particles, thereby forming a liquid-particle suspension;adding the suspension to the porous materials; andremoving the liquid, thereby forming the porous materials having the at least one of the micro-particles or nano-particles immobilized on the at least one of the internal pore surfaces or the external pore surfaces. 11. The method as defined in claim 10 wherein the at least one of the micro-particles or the nano-particles is selected from natural materials, synthetic materials, organic materials, inorganic materials, metallic materials, composites thereof, and combinations thereof. 12. The method as defined in claim 10 wherein the at least one of the micro-particles or nano-particles is a controlled release particle having an agent embedded therein. 13. The method as defined in claim 12 wherein the agent is selected from proteins, hormones, DNA, RNA, nutrients, drugs, biologically regulating agents, and combinations thereof. 14. The method as defined in claim 12 wherein, prior to suspending the at least one of the micro-particles or nano-particles, the method further comprises varying at least one property of the at least one of the micro-particles or nano-particles, thereby altering at least one release characteristic of the agent. 15. The method as defined in claim 10 wherein removing the liquid is accomplished by at least one of freeze-drying, vacuum drying, evaporation, or exchange with a non-solvent of the particles and the porous material. 16. Porous materials formed by the method of claim 10.
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