IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0355362
(2012-01-20)
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등록번호 |
US-8568799
(2013-10-29)
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발명자
/ 주소 |
- Jia, Qi
- Nichols, Timothy C.
- Rhoden, Eric E.
- Waite, Scott
|
출원인 / 주소 |
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
5 인용 특허 :
78 |
초록
▼
The present disclosure provides compositions and methods for alleviating inflammatory-associated diseases and conditions. These methods include administering individual and/or a mixture of multiple flavans isolated from a single or multiple Acacia genus of plants. The present disclosure also include
The present disclosure provides compositions and methods for alleviating inflammatory-associated diseases and conditions. These methods include administering individual and/or a mixture of multiple flavans isolated from a single or multiple Acacia genus of plants. The present disclosure also includes methods for isolating and purifying from an Acacia genus of plants a composition of flavans having dual specificity for cyclooxygenase (COX-2) and 5-lipoxygenase (5-LO) enzymes.
대표청구항
▼
1. A method for alleviating pain, comprising administering to a human or animal in need thereof a therapeutically effective amount of an Acacia extract enriched for catechin and epicatechin, wherein the method alleviates cyclooxygenase and 5-lipoxygenase mediated inflammation in the human or animal.
1. A method for alleviating pain, comprising administering to a human or animal in need thereof a therapeutically effective amount of an Acacia extract enriched for catechin and epicatechin, wherein the method alleviates cyclooxygenase and 5-lipoxygenase mediated inflammation in the human or animal. 2. The method according to claim 1, wherein the Acacia is selected from Acacia catechu, Acacia concinna, Acacia farnesiana, Acacia senegal, Acacia speciosa, Acacia arabica, Acacia caesia, Acacia pennata, Acacia sinuata, Acacia mearnsii, Acacia picnantha, Acacia dealbata, Acacia auriculiformis, Acacia holoserecia, or Acacia mangium. 3. The method according to claim 1, wherein the extract is from an Acacia plant part selected from the group consisting of stems, stem barks, trunks, trunk barks, twigs, tubers, roots, root barks, young shoots, seeds, rhizomes, flowers and other reproductive organs, leaves and other aerial parts. 4. The method according to claim 1, wherein the pain associated with the cyclooxygenase and 5-lipoxygenase mediated inflammation is selected from the group consisting of osteoarthritis, rheumatoid arthritis, menstrual cramps, systemic lupus erythematosis, psoriasis, chronic tension headache, migraine headaches, inflammatory bowel disease; topical wounds, minor abrasions, sunburn, contact dermatitis, and solid cancers. 5. The method according to claim 1, wherein the Acacia extract is comprised of 0.01% to 100% of flavans. 6. The method according to claim 1, wherein the Acacia extract is administered at a dose of 0.01 to 200 mg/kg of body weight of the human or animal. 7. The method according to claim 1, wherein the route of the administration is selected from the group consisting of oral, topical, suppository, intravenous, intradermic, intragaster, intramusclar, intraperitoneal, and intravenous. 8. The method according to claim 1, wherein the extract is comprised of at least 14.83% catechin/epicatechin. 9. The method according to claim 1, wherein the pain is joint pain. 10. The method according to claim 9, wherein the joint pain is osteoarthritis, rheumatoid arthritis, or systemic lupus erythematosis. 11. A method for improving joint comfort, comprising administering to a human or animal in need thereof an effective amount of an Acacia extract enriched for catechin and epicatechin, wherein the method alleviates cyclooxygenase and 5-lipoxygenase mediated inflammation in the human or animal. 12. The method according to claim 11, wherein the Acacia is selected from Acacia catechu, Acacia concinna, Acacia farnesiana, Acacia senegal, Acacia speciosa, Acacia arabica, Acacia caesia, Acacia pennata, Acacia sinuata, Acacia mearnsii, Acacia picnantha, Acacia dealbata, Acacia auriculiformis, Acacia holoserecia, or Acacia mangium. 13. The method according to claim 11, wherein the extract is from an Acacia plant part selected from the group consisting of stems, stem barks, trunks, trunk barks, twigs, tubers, roots, root barks, young shoots, seeds, rhizomes, flowers and other reproductive organs, leaves and other aerial parts. 14. The method according to claim 11, wherein the cyclooxygenase and 5-lipoxygenase mediated inflammation is osteoarthritis, rheumatoid arthritis, or systemic lupus erythematosis. 15. The method according to claim 11, wherein the Acacia extract is comprised of 0.01% to 100% of flavans. 16. The method according to claim 11, wherein the Acacia extract is administered at a dose of 0.01 to 200 mg/kg of body weight of the human or animal. 17. The method according to claim 11, wherein the route of the administration is selected from the group consisting of oral, topical, suppository, intravenous, intradermic, intragaster, intramusclar, intraperitoneal, and intravenous. 18. The method according to claim 11, wherein the extract is comprised of at least 14.83% catechin/epicatechin.
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