IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0453767
(2012-04-23)
|
등록번호 |
US-8571286
(2013-10-29)
|
발명자
/ 주소 |
- Soenksen, Dirk G.
- Zirker-Smith, Kathy
|
출원인 / 주소 |
- Leica Biosystems Imaging, Inc.
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
6 인용 특허 :
61 |
초록
▼
Systems and methods for improving quality assurance in pathology using automated quality assessment and digital image enhancements on digital slides prior to analysis by the pathologist are provided. A digital pathology system (slide scanning instrument and software) creates, assesses and improves t
Systems and methods for improving quality assurance in pathology using automated quality assessment and digital image enhancements on digital slides prior to analysis by the pathologist are provided. A digital pathology system (slide scanning instrument and software) creates, assesses and improves the quality of a digital slide. The improved digital slide image has a higher image quality that results in increased efficiency and accuracy in the analysis and diagnosis of such digital slides when they are reviewed on a monitor by a pathologist. These improved digital slides yield a more objective diagnosis than reading the corresponding glass slide under a microscope.
대표청구항
▼
1. A computer implemented method of providing quality assurance in pathology, where one or more processors are programmed to perform steps comprising: acquiring a digital image of a pathological sample disposed on a glass slide;comparing one or more characteristics of the digital image against one o
1. A computer implemented method of providing quality assurance in pathology, where one or more processors are programmed to perform steps comprising: acquiring a digital image of a pathological sample disposed on a glass slide;comparing one or more characteristics of the digital image against one or more predetermined criteria to determine if a quality of the digital image is sufficient;if it is determined that the quality of the digital image is insufficient, rejecting the glass slide to cause a new glass slide to be prepared; and,when it is determined that the quality of the digital image is sufficient, enhancing at least a portion of the digital image. 2. The method of claim 1, wherein acquiring the digital image comprises scanning the digital image using a line scanning system, and further comprising acquiring a second digital image of a second pathological sample disposed on the new glass slide using the line scanning system. 3. The method of claim 2, further comprising, if it is determined that the quality of the second digital image is insufficient, modifying parameters of the line scanning system and reacquiring the second digital image using said modified parameters. 4. The method of claim 3, wherein modifying the parameters of the line scanning system comprises changing a brightness of a light of the line scanning system. 5. The method of claim 1, wherein enhancing the digital image comprises transforming the digital image into a different color space. 6. The method of claim 1, wherein enhancing the digital image comprises enhancing spatial details in the digital image. 7. The method of claim 1, wherein enhancing the digital image comprises enhancing a color of a stain captured in the digital image. 8. The method of claim 7, wherein enhancing the color of the stain comprises changing the color of the stain. 9. The method of claim 1, wherein enhancing the digital image comprises, based on pattern recognition, automatically identifying regions of the digital image having diagnostic significance. 10. The method of claim 1, further comprising sending the enhanced digital image to at least one recipient. 11. The method of claim 10, further comprising: accessing a database of reference images;identifying reference images which match one or more patterns in the digital image; andsending the identified reference images to the at least one recipient. 12. The method of claim 10, wherein the recipient is a remote viewing station, and wherein sending the enhanced digital image to the at least one recipient comprises sending the enhanced digital image over at least one network. 13. The method of claim 10, further comprising: acquiring a digital image of a barcode disposed on the glass slide; anddetermining the at least one recipient based on the digital image of the barcode. 14. A system for providing quality assurance in pathology, the system comprising: at least one hardware processor thatacquires a digital image of a pathological sample disposed on a glass slide,compares one or more characteristics of the digital image against one or more predetermined criteria to determine if a quality of the digital image is sufficient,if it is determined that the quality of the digital image is insufficient, rejects the glass slide to cause a new glass slide to be prepared, and,when it is determined that the quality of the digital image is sufficient, enhances at least a portion of the digital image. 15. The system of claim 14, wherein the system further comprises a line scan camera, wherein acquiring the digital image comprises scanning the digital image using the line scan camera, and further comprising acquiring a second digital image of a second pathological sample disposed on the new glass slide using the line scan camera. 16. The system of claim 15, wherein the at least one hardware processor, if it is determined that the quality of the second digital image is insufficient, modifies parameters of the line scan camera and reacquires the second digital image using said modified parameters. 17. The system of claim 16, wherein modifying the parameters of the line scan camera comprises changing a brightness of an illuminating light. 18. The system of claim 14, wherein enhancing the digital image comprises transforming the digital image into a different color space. 19. The system of claim 14, wherein enhancing the digital image comprises enhancing spatial details in the digital image. 20. The system of claim 14, wherein enhancing the digital image comprises enhancing a color of a stain captured in the digital image. 21. The system of claim 20, wherein enhancing the color of the stain comprises changing the color of the stain. 22. The system of claim 14, wherein enhancing the digital image comprises, based on pattern recognition, automatically identifying regions of the digital image having diagnostic significance. 23. The system of claim 14, wherein the at least one hardware processor sends the enhanced digital image to at least one recipient. 24. The system of claim 23, wherein the at least one hardware processor: accesses a database of reference images;identifies reference images which match one or more patterns in the digital image; andsends the identified reference images to the at least one recipient. 25. The system of claim 23, wherein the recipient is a remote viewing station, and wherein sending the enhanced digital image to the at least one recipient comprises sending the enhanced digital image over at least one network. 26. The system of claim 23, wherein the at least one hardware processor: acquires a digital image of a barcode disposed on the glass slide; anddetermines the at least one recipient based on the digital image of the barcode.
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