IPC분류정보
| 국가/구분 |
United States(US) Patent
등록
|
| 국제특허분류(IPC7판) |
|
| 출원번호 |
US-0447045
(2007-10-25)
|
| 등록번호 |
US-8573197
(2013-11-05)
|
| 국제출원번호 |
PCT/US2007/022830
(2007-10-25)
|
| §371/§102 date |
20091224
(20091224)
|
| 국제공개번호 |
WO2008/051621
(2008-05-02)
|
|
발명자
/ 주소 |
- Axford, George S
- Glusker, Mark
- Alston, William W
- Palmer-Felgate, John
- Wilkins, Jonathan
- Foss, Willard R
- Rao, Nagaraja
- Postich, Mark
- Pakala, Neeraj R
- Maltz, David S
- Ung, Keith
|
| 출원인 / 주소 |
|
| 대리인 / 주소 |
|
| 인용정보 |
피인용 횟수 :
0 인용 특허 :
44 |
초록
▼
Methods and apparatuses for the pulmonary delivery of a composition, such as methods and apparatuses for dispersing dry powder medicaments for inhalation by a patient. Elements or aspects of the apparatuses, including receptacle puncturing mechanisms, deoccluding devices, receptacle impacting device
Methods and apparatuses for the pulmonary delivery of a composition, such as methods and apparatuses for dispersing dry powder medicaments for inhalation by a patient. Elements or aspects of the apparatuses, including receptacle puncturing mechanisms, deoccluding devices, receptacle impacting devices, and receptacle lock devices or systems.
대표청구항
▼
1. An apparatus, comprising: a support for supporting a receptacle comprising a blister having a wall;an outlet;a feed tube communicating with the outlet; and a mechanism configured to create at least one arc-shaped air inlet opening in a wall of the blister, the mechanism comprising a blade having
1. An apparatus, comprising: a support for supporting a receptacle comprising a blister having a wall;an outlet;a feed tube communicating with the outlet; and a mechanism configured to create at least one arc-shaped air inlet opening in a wall of the blister, the mechanism comprising a blade having a leading edge, wherein the leading edge comprises an elliptical leading edge having a rho value from 0.1 to 0.5, and a yaw value of 4 to 10 degrees as measured from a center and wherein the blade is configured and arranged to cut an opening in the wall of the blister wherein a smooth edge is produced. 2. The apparatus of claim 1, wherein the receptacle comprises a powder-containing receptacle, wherein the feed tube is structured and arranged to deliver the powder from the receptacle to the outlet, and wherein the mechanism is configured to create at least one opening in a wall of the receptacle by causing a puncture in the wall and causing a tearing of the wall. 3. The apparatus of claim 1, further comprising a puncturing and/or deoccluding device arranged within the feed tube. 4. The apparatus of claim 3, wherein the puncturing and/or deoccluding device comprises a blunt end which punctures the wall of the receptacle so as to allow an air flow from the receptacle and into the feed tube. 5. The apparatus of claim 3, wherein the puncturing and/or deoccluding device comprises one of: a generally V-shaped wire; anda portion which punctures the wall of the receptacle so as to allow an air flow from the receptacle and into the feed tube. 6. The apparatus of claim 3, wherein the puncturing and/or deoccluding device comprises a wire having a portion near an inner surface of the feed tube, and a puncturing portion. 7. The apparatus of claim 3, wherein the puncturing and/or deoccluding device comprises a member that is structured and arranged to at least partially rotate and deocclude the inner surface of the feed tube. 8. The apparatus of claim 1, further comprising a receptacle impacting device. 9. The apparatus of claim 8, wherein the receptacle impacting device comprises at least one arm that impacts the receptacle during or after insertion of the receptacle into the apparatus. 10. The apparatus of claim 8, wherein the receptacle impacting device rotates and impacts the receptacle during or after insertion of the receptacle into the apparatus. 11. The apparatus of claim 8, wherein the receptacle impacting device comprises a plurality of radially extending arms. 12. The apparatus of claim 8, wherein at least one of the radially extending arms is moved by the receptacle during insertion of the receptacle into the apparatus. 13. The apparatus of claim 12, wherein at least one of the radially extending arms is caused to move during insertion of the receptacle into the apparatus and at least another of the radially extending arms impacts the receptacle during insertion of the receptacle into the apparatus. 14. The apparatus of claim 8, further comprising a biasing member that causes the receptacle impacting device to impact the receptacle during insertion of the receptacle into the apparatus. 15. The apparatus of claim 1, further comprising a trigger mechanism that allows an air flow from the feed tube to the outlet when sufficient vacuum is generated at the outlet of the apparatus. 16. The apparatus of claim 1, further comprising a blister containing a powder comprising a medicament. 17. A method of opening a blister using the apparatus of claim 1, comprising: inserting a blister containing a powder into the apparatus; andcreating, with the mechanism configured to create at least one arc-shaped air inlet opening in a wall of the blister, a puncture in the wall and then a tear in the wall, wherein the tearing bends torn edges of the wall inwardly into the blister. 18. The method of claim 17, comprising: rotating one portion of a housing relative to another portion of the housing, wherein the rotating causes the mechanism configured to create the at least one arc-shaped air inlet opening in a wall of the blister to puncture the wall and then to tear the wall, wherein the tearing bends torn edges of the wall inwardly into the blister. 19. The method of claim 18, further comprising: rotating one portion of a housing relative to another portion of the housing, wherein the rotating automatically causes the mechanism configured to create the at least one arc-shaped air inlet opening in a wall of the blister to puncture the wall and then to tear the wall, whereby the tearing bends torn edges of the wall inwardly into the blister; andgenerating negative pressure on a mouthpiece coupled to the outlet of the apparatus. 20. A mechanism configured to create at least one opening in a wall of a blister, the mechanism comprising: a support; andat least one protruding member arranged on the support, the at least one protruding member comprising a blade having a leading edge, wherein the leading edge comprises an elliptical leading edge having a rho value from 0.1 to 0.5, and a yaw value of 4 to 10 degrees as measured from a center, and wherein the at least one protruding member is structured and arranged to initially puncture and then propagate an arc-shaped tear in the wall of the blister. 21. The mechanism of claim 20, wherein the mechanism is adapted for use in an apparatus for aerosolizing of powder. 22. The mechanism of claim 20, wherein there are a plurality of protruding members structured and arranged to form at least two spaced-apart arc-shaped openings in the wall of the blister. 23. The mechanism of claim 20, wherein the at least one protruding member comprises a substantially arc-shaped tooth. 24. The mechanism of claim 23, wherein the substantially arc-shaped tooth comprises a pointed free end and a substantially blunt side leading edge. 25. The mechanism of claim 24, wherein the substantially blunt side leading edge is structured and arranged to cause a tearing of the wall, whereby the tearing bends torn edges of the wall inwardly into the blister. 26. The mechanism of claim 20, wherein the at least one protruding member comprises plastic.
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