The invention features bone screws having a threaded screw body and a screw head attached to one end of the screw body, the bone screw further including: a) an interior channel extending longitudinally through the screw head and through at least a portion of the screw body, wherein the interior chan
The invention features bone screws having a threaded screw body and a screw head attached to one end of the screw body, the bone screw further including: a) an interior channel extending longitudinally through the screw head and through at least a portion of the screw body, wherein the interior channel has a width of less than 5.0 millimeters; and b) a plurality of radially-disposed delivery channels connecting the interior channel to the exterior of the screw body, each delivery channel having exterior openings. The invention further features devices that include a bone screw and a delivery manifold detachably attached to the screw head of the bone screw. In addition, the invention features methods of treating a patient having a bone defect by using a bone screw described herein.
대표청구항▼
1. A bone screw comprising: a) a screw body comprising a plurality of threads along all or a portion of said screw body;b) a screw head attached to one end of said screw body;c) an interior channel extending longitudinally through said screw head and through at least a portion of said screw body, wh
1. A bone screw comprising: a) a screw body comprising a plurality of threads along all or a portion of said screw body;b) a screw head attached to one end of said screw body;c) an interior channel extending longitudinally through said screw head and through at least a portion of said screw body, wherein said interior channel of said screw body has a width of less than 5.0 millimeters (mm);d) a plurality of radially-disposed delivery through channels connecting said interior channel to an exterior of said screw body, said delivery through channels comprising exterior openings;e) a screw tip attached to said screw body at an end opposite to the screw head, wherein said screw tip is narrower than the screw body; andf) at least one helical exterior groove extending continuously along the exterior of said screw body, wherein said exterior groove extends through said plurality of threads of said screw body and connects each of said exterior openings of said delivery through channels, wherein said threads are interrupted only by said helical exterior groove. 2. The bone screw of claim 1, wherein said interior channel has a width of up to 2.0 mm. 3. The bone screw of claim 1, wherein said exterior openings are: i) of varying cross-sectional areas;ii) substantially circular, substantially cylindrical, substantially slot-shaped, substantially square, or substantially polygonal; oriii) comprised of substantially circular exterior openings and substantially slot-shaped exterior openings. 4. The bone screw of claim 1, wherein said delivery channels are sized to generate substantially equal flow rates of a flowable medium extruded through each said delivery channel following introduction of said flowable medium through said screw head into said interior channel. 5. The bone screw of claim 4, wherein said flowable medium comprises bone void filler material, cement, or a pharmaceutical agent. 6. The bone screw of claim 1, wherein each of said delivery channels is tapered along at least a portion of its radial axis or is substantially cylindrical. 7. The bone screw of claim 1, wherein said exterior openings are positioned between alternating threads of said screw body. 8. The bone screw of claim 1, wherein said interior channel extends through substantially the full length of said screw body. 9. The bone screw of claim 1, wherein for each of said delivery channel and exterior opening, one or more additional delivery channels and exterior openings are positioned at substantially the same longitudinal distance from said screw head and are positioned substantially 180 degrees, 120 degrees, or 90 degrees apart around said longitudinal axis of said screw body. 10. The bone screw of claim 1, wherein the depth of said at least one exterior groove is less than the depth of said delivery channels. 11. The bone screw of claim 1, comprising two, three, four, or more exterior grooves that are substantially equidistant relative to each other. 12. The bone screw of claim 1, comprising between 1 and 200 delivery channels. 13. The bone screw of claim 1, wherein said exterior openings range in cross-sectional area from 0.1 mm2 to 12 mm2, or wherein said exterior openings are substantially circular and range in diameter from 0.1 mm to 4 mm. 14. The bone screw of claim 1, wherein: i) the length of said screw body is between 10 mm and 200 mm;ii) the major diameter of said screw body is between 2 mm and 20 mm;iii) the threads of said bone screw are spaced between 0.5 mm and 500 mm apart;iv) the radial height of said threads is between 0.1 mm and 20 mm;v) the diameter of said screw head is between 3 mm and 30 mm; orvi) the height of said screw head is between 1 mm and 25 mm. 15. The bone screw of claim 1, wherein said bone screw comprises stainless steel alloy, titanium alloy, commercially pure titanium, cobalt chrome, or polyetheretherketone. 16. The bone screw of claim 1, wherein said screw head further comprises a sealable polymeric barrier that separates an interior region of the screw head from the exterior environment of said bone screw, thereby forming a reservoir within said screw head. 17. The bone screw of claim 16, wherein said sealable polymeric barrier is a silicone elastomer. 18. The bone screw of claim 1, further comprising an internal plug that fully or partially occludes said interior channel or one or more of said delivery channels, wherein said internal plug is positionable along the length of said interior channel or is a solid state component of said bone screw. 19. The bone screw of claim 18, wherein said internal plug is solid, substantially cylindrical with a hollow core, substantially cylindrical with a hollow core and at least one solid end, or comprises a flowable medium selected from polyethylene, a metal alloy, a bone void filler material, a cement, or a pharmaceutical agent that is capable of releasing from said plug by fluid dissolution. 20. The bone screw of claim 1, wherein said interior channel has a diameter of up to 4.0 mm. 21. The bone screw of claim 1, wherein said bone screw is capable of delivering bone cement through each of said delivery channels following introduction of said bone cement through said screw head into said interior channel. 22. The bone screw of claim 21, wherein said bone screw is configured to allow delivery of said bone cement by application of manual pressure. 23. The bone screw of claim 1, wherein the depth of the exterior groove is between 0.1 mm and 1.0 mm. 24. The bone screw of claim 1, wherein said exterior openings are positioned along the length of said screw body. 25. The bone screw of claim 1, wherein said exterior openings are positioned between one or more threads of said screw body. 26. The bone screw of claim 1, wherein said exterior openings are arrayed in increasing cross-sectional area along a direction distal to said screw head. 27. The bone screw of claim 1, wherein said interior channel is substantially cylindrical. 28. The bone screw of claim 1, wherein said interior channel decreases in width along a direction distal to said screw head. 29. The bone screw of claim 1, wherein said interior channel decreases in width substantially linearly as a function of longitudinal distance from said screw head. 30. The bone screw of claim 1, wherein said interior channel decreases in width in a step-wise fashion along a direction distal to said screw head. 31. The bone screw of claim 1, wherein: i) the length of said screw body is between 10 mm and 200 mm;ii) the major diameter of said screw body is between 2 mm and 20 mm;iii) the threads of said bone screw are spaced between 0.5 mm and 500 mm apart;iv) the radial height of said threads is between 0.1 mm and 20 mm;v) the diameter of said screw head is between 3 mm and 30 mm; andvi) the height of said screw head is between 1 mm and 25 mm. 32. The bone screw of claim 1, wherein said screw head is machined to fit a delivery manifold capable of introducing a flowable medium to the interior channel of said bone screw. 33. The bone screw of claim 1, wherein said screw head is machined to fit a rotational driver capable of engaging a recess within said screw head. 34. The bone screw of claim 1, wherein said screw head is hollow. 35. The bone screw of claim 1, wherein said screw head comprises interior or exterior threads. 36. The bone screw of claim 1, wherein said screw head is substantially circular, substantially hexagonal, substantially square, or substantially hexagonal. 37. The bone screw of claim 1, wherein said screw head is machined to be driven by a spanner or has a hexagonal opening, a Robertson opening, a slotted opening, a Phillips opening, a Torx opening, a triple square opening, a polydrive opening, a one-way clutch opening, a spline drive opening, a double hex opening, or a Bristol opening. 38. The bone screw of claim 1, wherein said bone screw is machined for use as a fastener or anchor for an implant. 39. The bone screw of claim 1, wherein said interior channel has a width between 0.5 mm and 5.0 mm. 40. The bone screw of claim 1, wherein said interior channel extends longitudinally through the distal end of said screw body. 41. The bone screw of claim 1, wherein the distal end of the screw body is closed. 42. The bone screw of claim 1, wherein said screw body is fully threaded. 43. The bone screw of claim 1, wherein said bone screw is a fixation bone screw. 44. The bone screw of claim 1, wherein said bone screw is configured for use in the repair of a bone defect selected from the group consisting of a subarticular fracture, a defect of the spine or vertebra, and a defect of the radius, ulna, fibula, clavicle, humerus, pelvis, femur, patella, tibia, talus, calcaneus, navicular, cuneiforms, metatarsals, metacarpals, phalanges, scapula, ankle, teeth, or mandible. 45. The bone screw of claim 1, wherein said bone screw is a vertebral fixation screw. 46. The bone screw of claim 1, wherein said bone screw is configured for maxillomandibular or craniofacial fixation.
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