Medical devices having a coating of biologic macromolecules
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61F-002/12
A61K-038/02
출원번호
US-0708993
(2010-02-19)
등록번호
US-8574612
(2013-11-05)
발명자
/ 주소
Edelman, Peter
출원인 / 주소
Boston Scientific Scimed, Inc.
대리인 / 주소
Kenyon & Kenyon LLP
인용정보
피인용 횟수 :
0인용 특허 :
11
초록▼
A medical device having a coating of biologic macromolecules. The coating of biologic macromolecules is protected by a temporary protective layer disposed over the biologic macromolecules. The temporary protective layer serves to protect the structure (e.g., conformation) and/or function (e.g., targ
A medical device having a coating of biologic macromolecules. The coating of biologic macromolecules is protected by a temporary protective layer disposed over the biologic macromolecules. The temporary protective layer serves to protect the structure (e.g., conformation) and/or function (e.g., target binding capacity) of the biologic macromolecules during processing, storage, handling, and/or delivery (e.g., implantation or insertion into a patient) of the medical device. Upon implantation or insertion into a patient's body, the temporary protective layer may dissolve to expose the biologic macromolecules to the physiologic environment.
대표청구항▼
1. A medical device having a coating, the coating comprising: biologic macromolecules disposed over a surface of the medical device, wherein the biologic macromolecules are capable of binding endothelial cells; anda temporary protective layer disposed over at least a portion of the biologic macromol
1. A medical device having a coating, the coating comprising: biologic macromolecules disposed over a surface of the medical device, wherein the biologic macromolecules are capable of binding endothelial cells; anda temporary protective layer disposed over at least a portion of the biologic macromolecules, the temporary protective layer comprising a water-soluble low molecular weight carbohydrate, and wherein the temporary protective layer substantially dissolves within 24 hours after implantation or insertion of the medical device in a patient. 2. The medical device of claim 1, wherein the biologic macromolecules are antibodies that are directed to a cell surface component of endothelial cells. 3. The medical device of claim 1, wherein the biologic macromolecules form a monolayer. 4. The medical device of claim 1, wherein the low molecular weight carbohydrate is a monosaccharide or a disaccharide. 5. The medical device of claim 1, wherein the carbohydrate is a non-reducing carbohydrate. 6. The medical device of claim 1, wherein the temporary protective layer substantially dissolves within 6 hours after implantation or insertion of the medical device in a patient. 7. The medical device of claim 1, wherein the thickness of the temporary protective layer is in the range of 0.5 to 10 μm. 8. The medical device of claim 1, wherein the medical device is a stent. 9. The medical device of claim 1, wherein the medical device is a balloon catheter, and wherein the surface is the surface of a balloon on the balloon catheter. 10. A medical device having a coating, the coating comprising: a monolayer of antibodies disposed over a surface of the medical device, wherein the antibodies are directed to a cell surface component of endothelial cells; anda temporary protective layer disposed over at least a portion of the monolayer of antibodies, the temporary protective layer comprising a monosaccharide or a disaccharide, and wherein the temporary protective layer substantially dissolves within 6 hours after implantation or insertion of the medical device in a patient. 11. The medical device of claim 1, wherein the low molecular weight carbohydrate is a monosaccharide or a disaccharide, and the temporary protective layer substantially dissolves within 6 hours after implantation or insertion of the medical device in a patient. 12. The medical device of claim 11, wherein the low molecular weight carbohydrate is a non-reducing monosaccharide or a non-reducing disaccharide. 13. The medical device of claim 11, wherein the temporary protective layer substantially dissolves within one hour after implantation or insertion of the medical device in a patient. 14. The medical device of claim 12, wherein the temporary protective layer substantially dissolves within one hour after implantation or insertion of the medical device in a patient.
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