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특허 상세정보

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Supplemented matrices for the repair of bone fractures

특허상세정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판) A61K-038/29    A61K-009/00    C07K-014/635   
미국특허분류(USC) 514/011.8; 514/013.6; 514/016.7; 424/484; 530/382
출원번호 US-0167488 (2011-06-23)
등록번호 US-8575101 (2013-11-05)
발명자 / 주소
출원인 / 주소
대리인 / 주소
    Pabst Patent Group LLP
인용정보 피인용 횟수 : 0  인용 특허 : 50
초록
▼

Supplemented matrices comprising a PTH releasably incorporated therein, optionally containing a granular material, which are used to heal bone fractures, particularly bone fractures with a risk of becoming delayed unions or non-unions, are described herein. The PTH is incorporated either through covalent linkage to the matrix or through non-covalent interaction with the matrix and/or the granules. These supplemented matrices decrease the time of healing compared to autograft and or trigger healing of bone fractures which otherwise would not heal. The mat...

대표
청구항
▼

1. A method of repairing a bone fracture, comprising administering to the site of the bone fracture, a formulation capable of forming a supplemented matrix under physiological conditions, wherein the bone fracture is a discontinuity in the bone structure which results in two or more distinct bone segments of the fractured bone,and forming a supplemented matrix at the site,wherein the supplemented matrix comprises (i) PTH or a PTH fusion peptide(ii) a matrix material comprising fibrin,wherein the PTH or PTH fusion peptide is present in an effective amount...

이 특허에 인용된 특허 (50)

  1. Schroeder Jacqueline A. (Redwood City CA) Bentz Hanne (Newark CA) Estridge Trudy D. (Fremont CA). Affinity bound collagen matrices for the delivery of biologically active agents. USP1997125693341.
  2. Krstenansky John L. ; Nestor John J. ; Ho Teresa H.. Analogs of parathyroid hormone and parathyroid hormone relate peptide synthesis and use for the treatment of osteoporos. USP1998115840837.
  3. Reed Guy L. (Winchester MA) Haber Edgar (Salisbury NH) Matsueda Gary R. (Princeton NJ). Antibodies that bind to a
  4. Scheicher Hans (Rondell Neuwittelsbach 4 8000 Mnchen 19 DEX) Wendler Eberhard (Sedelhofstr. 3 8000 Mnchen 60 DEX). Bone replacement material on the basis of carbonate and alkali containing calciumphosphate apatites. USP1990044917702.
  5. Lagow,Richard J.. Calcium phosphate bone replacement materials and methods of use thereof. USP2006057045105.
  6. Kilburn Douglas G. (Vancouver) Miller Robert C. (Vancouver) Warren Richard A. J. (Vancouver) Gilkes Neil R. (Vancouver CAX). Cellulose binding fusion proteins having a substrate binding region of cellulase. USP1993045202247.
  7. J. Alexander Marchosky. Compositions and methods for forming and strengthening bone. USP2002046372257.
  8. Kilburn Douglas G.,CAX ; Humphries Keith R.,CAX ; Doheny James G.,CAX ; Jervis Eric,CAX ; Alimonti Judie,CAX. Compositions and methods for modulating cell proliferation using growth factor-polysaccharide binding fusion proteins. USP1999025874308.
  9. Lee,John C.; Yeh,Lee Chuan C.. Compositions and therapeutic methods using morphogenic proteins and stimulatory factors. USP2006047026292.
  10. Oldenburg Kevin R. ; Selick Harold E.. Compounds with PTH activity. USP1998095814603.
  11. Larsson Rolf (Uppsala SEX) Westberg David (Uppsala SEX) Formgren Birgitta (Uppsala SEX) Uhlin Anders (Uppsala SEX). Conjugate, its preparation and use and a substrate prepared with the conjugate. USP1996065529986.
  12. Chorev Michael ; Rosenblatt Michael. Continuous low-dose administration of parathyroid hormone or its agonist. USP1998055747456.
  13. Edelman Elazer R. (Brookline MA) Langer Robert S. (Somerville MA) Klagsburn Michael (Newton MA) Mathiowitz Edith (Brookline MA). Controlled release systems containing heparin and growth factors. USP1992035100668.
  14. Rhee Woonza M. ; DeLustro Frank A. ; Berg Richard A.. Crosslinked polymer compositions and methods for their use. USP1999025874500.
  15. Peterson Dale R. ; Nousek-Goebl Nancy ; Glancy Todd P.. Endothelin-based compositions for enhancing connective tissue repair. USP2001106303138.
  16. Hubbell Jeffrey A.,CHX ; Schense Jason,CHX. Enzyme-mediated modification of fibrin for tissue engineering. USP2001126331422.
  17. Hubbell,Jeffrey A.; Schense,Jason C.; Sakiyama,Shelly E.. Enzyme-mediated modification of fibrin for tissue engineering: fibrin formulations with peptides. USP2007077241730.
  18. Hubbell, Jeffrey A.; Schense, Jason C.; Sakiyama, Shelly E.. Enzyme-mediated modification of fibrin for tissue engineering: incorporation of proteins. USP2005116960452.
  19. Jeffrey A. Hubbell CH; Jason C. Schense CH; Shelly E. Sakiyama CH. Enzyme-mediated modification of fibrin for tissue engineering: incorporation of proteins. USP2002106468731.
  20. Hubbell, Jeffrey A.; Schense, Jason. Enzyme-mediated modification of fivrin for tissue engineering. USP2003086607740.
  21. Hubbell, Jeffrey A.; Schense, Jason C.; Sakiyama Elbert, Shelly E.. Growth factor modified protein matrices for tissue engineering. USP2009107601685.
  22. Hubbell, Jeffrey A.; Schense, Jason C.; Sakiyama-Elbert, Shelly E.. Growth factor modified protein matrices for tissue engineering. USP2005056894022.
  23. L？tolf,Matthias; Schense,Jason; Hubbell,Jeffrey A.; Jen,Anna. Growth factor modified protein matrices for tissue engineering. USP2007077247609.
  24. Harris Robert B. ; Sobel Michael. Heparin-binding peptides. USP1999035877153.
  25. Foster Donald C. (Seattle WA). Hybrid plasminogen activator. USP1996045504001.
  26. Lidor Cobi (Herzeliya ILX) Dekel Samuel (Ramat-Gan ILX) Edelstein Samuel (Rehovot ILX) Meyer Michael S. (Tel-Aviv ILX). Method and compositions comprising a vitamin D derivatives for the local treatment of bone fractures. USP1991125069905.
  27. Tunkel Lev (Edison NJ) Krasovitski Boris (Nesher ILX). Method for energy separation and utilization in a vortex tube which operates with pressure not exceeding atmospheric pre. USP1996105561982.
  28. Kuderer, Hubert. Method of and apparatus for testing a photosensor. USP2003086608293.
  29. Burgess, Willson H.; Greisler, Howard P.; Drohan, William N.; Maciag, Thomas; MacPhee, Martin J.. Method of preparing a tissue sealant-treated biomedical material. USP2003056559119.
  30. Radomsky Michael. Method of promoting bone growth with hyaluronic acid and growth factors. USP2001046221854.
  31. Debra G. Gilbertson ; Charles E. Hart. Methods for promoting growth of bone using ZVEGF4. USP2002106468543.
  32. Hart, Charles E.; Gilbertson, Debra G.. Methods for promoting growth of bone using zvegf3. USP2003126663870.
  33. Murphy, William L.; Mooney, David J.; Kohn, David H.; Spalding, Gabriel C.; Dearing, Matthew T.. Mineral and cellular patterning on biomaterial surfaces. USP2003046541022.
  34. Bezemer, Jeroen Mattijs; de Wijn, Joost Robert; Nieuwenhuis, Jan. Molding of a polymer. USP2004056730721.
  35. Ting,Kang. NELL-1 enhanced bone mineralization. USP2006057052856.
  36. Tregear ; Geoffrey William. Parathyroid hormone. USP1978044086196.
  37. Hock Janet M. (Indianapolis IN). Parathyroid hormone and raloxifene for increasing bone mass. USP1996045510370.
  38. Larm Olle (Nyngsvgen 86 S-161 39 Bromma SEX). Process for covalent coupling for the production of conjugates, and polysaccharide containing products thereby obtained. USP1986094613665.
  39. Larm Olle (Nyngsvgen 86 S-161 39 Bromma SEX). Process for covalent coupling for the production of conjugates, and products hereby obtained. USP1989034810784.
  40. Kale,Sujata; Long,Michael W.. Process for ex vivo formation of mammalian bone and uses thereof. USP2007067229826.
  41. Kopetzki Erhard,DEX. Process for the production of peptides by way of streptavidin fusion proteins. USP2000106136564.
  42. Cappello Joseph. Products comprising substrates capable of enzymatic cross-linking. USP1998065773577.
  43. Treco Douglas A. (Arlington MA) Heartlein Michael W. (Boxborough MA) Selden Richard F. (Wellesley MA). Protein production and protein delivery. USP1997065641670.
  44. Kronenberg Henry M. (Belmont MA) Nussbaum Samuel R. (Weston MA) Doi Tomoko (Osaka JPX). Recombinant DNA method for production of parathyroid hormone. USP1992125171670.
  45. Clark Richard A. ; Greiling Doris,GBX ; Gailit James. Recombinant fibronectin-based extracellular matrix for wound healing. USP1999095958874.
  46. MacPhee Martin James ; Drohan William Nash ; Liau Gene ; Haudenschild Christian. Supplemented and unsupplemented tissue sealants, method of their production and use. USP2000096117425.
  47. MacPhee Martin James ; Drohan William Nash ; Lasa ; Jr. Carlos I.,PHX ; Liau Gene ; Haudenschild Christian. Supplemented and unsupplemented tissue sealants, methods of their production and use. USP2001036197325.
  48. MacPhee Martin James ; Drohan William Nash ; Woolverton Christoper J.. Supplemented and unsupplemented tissue sealants, methods of their production and use. USP2000046054122.
  49. Labroo Virender (Mill Creek WA) Busby Sharon J. (Seattle WA). Transglutaminase cross-linkable polypeptides and methods relating thereto. USP1995065428014.
  50. Driessens Ferdinand C. M.,DEX ; Wenz Robert,DEX. Tricalcium phosphate-containing biocement pastes comprising cohesion promoters. USP2001036206957.

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