IPC분류정보
국가/구분 |
United States(US) Patent
등록
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국제특허분류(IPC7판) |
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출원번호 |
US-0245608
(2011-09-26)
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등록번호 |
US-8575276
(2013-11-05)
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발명자
/ 주소 |
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출원인 / 주소 |
- KNC NER Acquisition Sub, Inc.
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대리인 / 주소 |
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인용정보 |
피인용 횟수 :
0 인용 특허 :
97 |
초록
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Synthesis methods for creating polymeric compounds comprising dihydroxyphenyl derivatives (DHPD), or DHPp i.e. polymers modified with DHPD, with desired surface active effects are described. The polymer backbone of DHPp has structural or performance features that can be tailored to control physical
Synthesis methods for creating polymeric compounds comprising dihydroxyphenyl derivatives (DHPD), or DHPp i.e. polymers modified with DHPD, with desired surface active effects are described. The polymer backbone of DHPp has structural or performance features that can be tailored to control physical properties of DHPp, allowing it to be useful for different applications i.e. tissue adhesives or sealants, adhesion promoting coatings, and antifouling coatings.
대표청구항
▼
1. A method for adhering a first surface to a second surface in a subject, comprising: a) providing a subject;b) providing a DHPD-modified linear polymer (DHPp) according to Formula (I): wherein LG is an optional linking group, DHPD is a dihydroxyphenyl derivative selected from dopamine or 3,4-dihyd
1. A method for adhering a first surface to a second surface in a subject, comprising: a) providing a subject;b) providing a DHPD-modified linear polymer (DHPp) according to Formula (I): wherein LG is an optional linking group, DHPD is a dihydroxyphenyl derivative selected from dopamine or 3,4-dihydroxyhydrocinnamic acid, and pB is a linear polymeric back bone;c) applying an effective amount of said phenyl derivative polymer to at least one of said first and said second surface in said subject; andd) approximating said first surface and said second surface such that said phenyl derivative polymer adheres said first surface to said second surface in said subject. 2. The method of claim 1, wherein said pB consists essentially of polyalkylene oxide. 3. The method of claim 1, wherein said pB is substantially a homopolymer. 4. The method of claim 1, wherein said DHPD-modified linear polymer (DHPp) is configured to cure at a predetermined rate. 5. The method of claim 1, wherein said DHPD-modified linear polymer (DHPp) is configured to degrade at a predetermined rate. 6. The method of claim 1, wherein at least one of said first surface or said second surface is a tissue. 7. The method of claim 6, wherein said first surface and said second surface are the same tissue. 8. The method of claim 6, wherein said first surface and said second surface are different tissue. 9. The method of claim 1, wherein said first surface is a living tissue and said second surface is a tissue implant. 10. The method of claim 1, wherein said first surface is a tissue and said second surface is device. 11. A method for sealing a surface in a subject, comprising: a) providing a subject;b) providing a DHPD-modified linear polymer DHPp according to Formula (II): wherein R1 is a monomer or prepolymer linked or polymerized to form a linear polymeric backbone (pB), DHPD is a dihydroxyphenyl derivative selected from dopamine or 3,4-dihydroxyhydrocinnamic acid, and LG is an optional linking group; andc) applying an effective amount of said phenyl derivative polymer to said surface in said subject. 12. The method of claim 11, wherein R1 is selected from the group consisting of polyether, polyester, polyamide, polyacrylate, and polyalkyl. 13. The method of claim 11, R1 is linked through urethane, urea, amide, ester, carbonate, or carbon-carbon bond formation. 14. The method of claim 11, wherein the pB comprises a polyacrylate, a polymethacrylate, a polyacrylamide, a polymethacrylamide, a polyacrylate ester, a polymethacrylate ester, a polyvinylic or a polyallylic polymeric backbone. 15. The method of claim 14, wherein the polyacrylate, polymethacrylate, polyacrylamide, polymethacrylamide, polyacrylate ester, polymethacrylate ester, polyvinylic or polyallylic polymeric backbone is selected from poly(ethylene glycol) methyl ether methacrylate, poly(ethylene glycol) methyl ether acrylamide, poly(ethylene glycol) methyl ether methacrylamide, acrylamide, N-acryloylmorpholine, 2-hydroxymethacrylate, N-isopropylacrylamide, 2-methoxyethyl acrylate, 3-methacryloylaminopropyldimethyl(3-sulfopropyl)ammonium hydroxide, vinylpyrrolidone, 3-acrylamidopropyl trimethylammonium, allylamine, 1,4-diaminobutane methacrylamide, 2-acrylamido-2-methyl-1-propanesulfonic acid, ethylene glycolmethacrylate phosphate and 2,2,2-trifluoroethyl methacrylate. 16. The method of claim 11, wherein said DHPD-modified linear polymer (DHPp) is configured to cure at a predetermined rate. 17. The method of claim 11, wherein said DHPD-modified linear polymer (DHPp) is configured to degrade at a predetermined rate. 18. The method of claim 11, wherein said DHPD-modified linear polymer (DHPp) comprises a predetermined burst strength. 19. The method of claim 11, wherein said surface is a tissue. 20. The method of claim 19, wherein said tissue comprises a wound.
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