IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
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출원번호 |
US-0851524
(2010-08-05)
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등록번호 |
US-8579856
(2013-11-12)
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발명자
/ 주소 |
- Sullivan, Timothy R.
- Nelson, Jeffrey
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출원인 / 주소 |
- Mystic Pharmaceuticals, Inc.
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대리인 / 주소 |
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인용정보 |
피인용 횟수 :
0 인용 특허 :
15 |
초록
▼
The delivery systems of the present disclosure are configurable to administer either single-dose or multiple-doses of one or more substances to a user, for example to the eye, nose, mouth, ear or rectum of the user. The precise and repeatable dosing features of the presently disclosed delivery syste
The delivery systems of the present disclosure are configurable to administer either single-dose or multiple-doses of one or more substances to a user, for example to the eye, nose, mouth, ear or rectum of the user. The precise and repeatable dosing features of the presently disclosed delivery systems overcome many of the disadvantages associated with known methods for dispensing substances to, for example, the eye of a user. The delivery systems administer precise doses of a substance to a precise location from unit dosage forms that may be single-dose or multiple-dose unit dosage forms, which may be externally or internally pierced.
대표청구항
▼
1. A drug delivery system comprising: a housing configured to contain one or more crushable unit dosage forms;a user activation mechanism, effective when activated, to engage a drug delivery mechanism comprising a piston drivable into at least one dosage form contained in the housing, wherein the ac
1. A drug delivery system comprising: a housing configured to contain one or more crushable unit dosage forms;a user activation mechanism, effective when activated, to engage a drug delivery mechanism comprising a piston drivable into at least one dosage form contained in the housing, wherein the activation mechanism provides a mechanical advantage, a mechanical disadvantage or a combination of mechanical advantage and disadvantage to the activation mechanism; anda discharge port formed in or contiguous with the housing and configured to release the contents of a dosage form upon activation of the activation mechanism. 2. The drug delivery system of claim 1, wherein the dosage forms are blisters comprising a piercable region and an internal piercing mechanism, wherein, the piercing mechanism comprises an internal channel positioned to release the content of the blister through the piercing mechanism in a spray, stream, or mist pattern and out the discharge port when the blister is crushed and the piercing mechanism pierces the piercable region. 3. The drug delivery system of claim 1, wherein the housing is configured to contain multiple dosage forms, and wherein the drug delivery system further comprises a mechanism to sequentially position a dosage form adjacent the dispensing channel and optionally to simultaneously advance a spent dosage form away from the dispensing channel. 4. The drug delivery system of claim 3, wherein the housing is configured to accept a cartridge containing one or more blister dosage forms and to position the dosage forms in dispensing position. 5. The drug delivery system of claim 4, wherein the housing is configured to accept a cartridge containing a single dosage form. 6. The drug delivery system of claim 4, wherein the housing is configured to accept a cartridge containing a plurality of dosage forms contained on a disc, a ring or a strip. 7. The drug delivery system of claim 6, comprising an indexing wheel knob connected to an indexing lever configured such that activating the indexing knob advances a unit dosage form into dispensing position. 8. The drug delivery system of claim 6, wherein the housing comprises a winding take-up wheel/torsion spring in engagement with an indexing sprocket attachable to a strip of blister dosage forms. 9. The drug delivery system of claim 4, wherein the housing is configured to accept a rotatable disc or ring containing a plurality of blister dosage forms. 10. The drug delivery system of claim 1, wherein the activation mechanism provides a mechanical disadvantage such that a pre-defined minimum threshold force must be applied to the activation mechanism in order to active a drug delivery mechanism. 11. The drug delivery system of claim 1, wherein the activation mechanism provides a mechanical advantage such that, when activated the force driving the piston into the dosage form is greater than the simultaneous force applied to the activating mechanism. 12. The drug delivery system of claim 1, wherein the activation mechanism comprises a hinge, spring, cam, or motorized drive. 13. The drug delivery system of claim 1, wherein the mechanically advantaged or disadvantaged mechanism comprises a lever, cam or an inclined plane. 14. The drug delivery system of claim 13, wherein a mechanical advantage or disadvantage is provided by an interaction of an angled face on an activation button and an angled face on a piston. 15. The drug delivery system of claim 13, wherein a mechanical advantage or disadvantage is provided by an interaction of an arcuate face on an activation button and an arcuate face on a piston. 16. The drug delivery system of claim 13, wherein the activation mechanism provides for a mechanical disadvantage during first stage of activation until a minimum threshold force is exerted and a mechanical advantage during a second stage of activation during which a piston is driven into a dosage form. 17. The drug delivery system of claim 2, wherein the dosage form contains a substance comprising an active pharmaceutical ingredient or biologic. 18. The drug delivery system of claim 17, wherein the substance is preservative-free. 19. The drug delivery system of claim 17, wherein the substance is dispensed as a drop, droplet, stream or spray upon release from the unit dosage form. 20. The drug delivery system of claim 17, wherein the substance is sterile until released from the unit dosage form. 21. The drug delivery system of claim 17, wherein the unit dosage forms further comprises a head space of gas or air. 22. The drug delivery system of claim 1, further comprising a delivery device configured to deliver the contents of a dosage form to a selected body part of a drug recipient. 23. The drug delivery system of claim 22, wherein the delivery system is designed to deliver a dosage of drug into to the eye, nose, mouth, ear, or rectum of a recipient. 24. The drug delivery system of claim 22, wherein the delivery device is an eyecup. 25. The drug delivery system of claim 22, wherein the delivery device further comprises a detachable cap. 26. The drug delivery system of claim 25, wherein the cap is configured as a storage device for dosage form containing cartridges. 27. The drug delivery system of claim 1, wherein the delivery system further comprises a programmable microprocessor. 28. The drug delivery system of claim 27, wherein the programmable microprocessor is a Printed Circuit Board or an Application Specific Integrated Circuit coupled to visual display interface and audible notification system. 29. The drug delivery system of claim 27, wherein the visual display interface is a Liquid Crystal Display or Light Emitting Diodes. 30. An ophthalmic drug delivery system comprising: a housing configured to contain one or more crushable unit dosage forms;a user activation mechanism, effective when activated, to engage a drug delivery mechanism comprising a piston drivable into at least one dosage form contained in the housing, wherein the activation mechanism provides a mechanical advantage, a mechanical disadvantage or a combination of mechanical advantage and disadvantage to the activation mechanism;a discharge port formed in or contiguous with the housing and configured to release the contents of a dosage form upon activation of the activation mechanism; andan eye cup attached to the housing disposed to direct the contents of the dosage form into the eye of a recipient. 31. The ophthalmic drug delivery system of claim 30, further comprising one or more unit dosage forms contained in the housing, wherein the dosage forms are blisters comprising a piercable region and an internal piercing mechanism, wherein, the piercing mechanism comprises an internal channel positioned to release the content of the blister through the piercing mechanism in a spray, stream, or mist pattern and out the discharge port when the blister is crushed and the piercing mechanism pierces the piercable region. 32. The ophthalmic drug delivery system of claim 31, wherein the dosage forms are contained in a cartridge. 33. The ophthalmic drug delivery system of claim 32, wherein the cartridge contains a plurality of unit dosage blisters configured on a strip, disk or ring, and further wherein the housing contains an indexing wheel connected to an indexing lever configured such that activating the indexing knob advances a unit dosage form into dispensing position. 34. The drug delivery system of claim 30, wherein the activation mechanism provides a mechanical disadvantage such that a pre-defined minimum threshold force must be applied to the activation mechanism in order to active a drug delivery mechanism. 35. The drug delivery system of claim 30, wherein the activation mechanism provides a mechanical advantage such that, when activated the force driving the piston into the dosage form is greater than the simultaneous force applied to the activating mechanism. 36. The drug delivery system of claim 30, wherein the activation mechanism comprises a hinge, spring, cam, or motorized drive. 37. The drug delivery system of claim 30, wherein the mechanically advantaged or disadvantaged mechanism comprises a lever, cam or an inclined plane. 38. The drug delivery system of claim 37, wherein a mechanical advantage or disadvantage is provided by an interaction of an angled face on an activation button and an angled face on a piston. 39. The drug delivery system of claim 37, wherein a mechanical advantage or disadvantage is provided by an interaction of an arcuate face on an activation button and an arcuate face on a piston. 40. The drug delivery system of claim 37, wherein the activation mechanism provides for a mechanical disadvantage during first stage of activation until a minimum threshold force is exerted and a mechanical advantage during a second stage of activation during which a piston is driven into a dosage form. 41. The drug delivery system of claim 32, wherein the unit dosage form cartridge comprises one or more aids for administering the unit dosage forms to a user selected from the group consisting of numbering, color coding, icon system coding, Braille, bar coding, and Radio Frequency Identification Device. 42. A drug delivery system comprising: a housing;a button on a surface of the housing and pivotable indexing lever that acts as a cover and an indexing lever from a closed position to a dispense position;a firing mechanism comprising a piston connected to a link contained in the housing and in contact with the button through the link;a discharge port attached to the housing and in fluid communication with a unit dosage form dispensing position in the housing; anda feed mechanism for a blister strip contained in the housing, and comprising a feed wheel, an indexing wheel, and a take-up wheel, effective to sequentially move unit dosage forms contained on the blister strip into dispensing position in front of the discharge port by turning the indexing wheel;wherein when the dispensing button is in the raised position, depressing the button forces the piston into an unit dosage form in the dispensing position, thereby forcing the contents of the unit dosage form through the discharge port into the eye, and wherein the link provides a mechanical advantage to the piston. 43. The drug delivery system of claim 42, wherein the link comprises an inclined plane cam or a lever. 44. The drug delivery system of claim 42, wherein the blister strip comprises a plurality of internally pierced unit dosage forms. 45. The drug delivery system of claim 42, comprising an indicator connected to the indexing wheel and visible from outside the housing, wherein the indicator comprises symbols to indicate the number of unused unit dosage forms on a blister strip. 46. The drug delivery system of claim 42, wherein the symbols are numbers, letters, colors, or a combination thereof. 47. The drug delivery system of claim 42, wherein the indexing mechanism comprises a rotating lever. 48. The drug delivery system of claim 42, wherein the indexing mechanism comprises a rotating lever that also acts as a cover to the drug discharge area. 49. The drug delivery system of claim 42, comprising an indicator port adjacent to the discharge port positioned to reveal dosage counter indicators on the delivery system when viewed from the exterior of the housing.
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