초록 ▼

The invention provides compositions comprising extended release memantine in combination with immediate release donepezil to a subject. Memantine in an extended release form containing 22.5 to 30 mg memantine or a pharmaceutically acceptable salt thereof in combination with donepezil achieves partic

The invention provides compositions comprising extended release memantine in combination with immediate release donepezil to a subject. Memantine in an extended release form containing 22.5 to 30 mg memantine or a pharmaceutically acceptable salt thereof in combination with donepezil achieves particular pharmacokinetic criteria such as change in plasma concentration of memantine over time and ratio of maximum memantine plasma concentration to mean memantine plasma concentration.

대표청구항 ▼

1. A method of treating a patient with a neurological condition, comprising orally administering to a human subject in need thereof: (a) 22.5 to 37.5 mg memantine or a pharmaceutically acceptable salt thereof provided in an extended release dosage form, wherein administration of a dose of said dosag

1. A method of treating a patient with a neurological condition, comprising orally administering to a human subject in need thereof: (a) 22.5 to 37.5 mg memantine or a pharmaceutically acceptable salt thereof provided in an extended release dosage form, wherein administration of a dose of said dosage form provides a mean plasma memantine concentration profile characterized by a change in memantine concentration of memantine as a function of time (dC/dT) that is less than about 50% of the dC/dT provided by the same quantity of an immediate release form of memantine, determined in a time period between 0 hours to 6 hours of administration of memantine, and wherein dC/dT is measured in a single-dose human PK study; and(b) a therapeutically effective amount of immediate release donepezil; wherein the neurological condition is selected from Alzheimer's disease, dementia, Parkinson's disease, and neuropathic pain. 2. The method of claim 1, comprising 25 mg to 37.5 mg memantine or a pharmaceutically acceptable salt thereof. 3. The method of claim 1, comprising 28 mg memantine or a pharmaceutically acceptable salt thereof. 4. The method of claim 1, wherein administration of a dose of the composition to a human subject provides a mean plasma memantine concentration profile characterized by dC/dT that is 2.1 ng/ml/hr or less, determined in a time period of 0 to 4 hours, and wherein dC/dT is measured in a single-dose human PK study. 5. The method of claim 4, wherein the dC/dT of 2.1 ng/ml/hr or less is determined in a time period of 2 to 4 hours. 6. The method of claim 2, wherein administration of a dose of the composition to a human subject provides a mean plasma memantine concentration profile characterized by dC/dT that is 2.1 ng/ml/hr or less, determined in a time period of 0 to 4 hours, and wherein dC/dT is measured in a single-dose human PK study. 7. The method of claim 6, wherein the dC/dT of 2.1 ng/ml/hr or less is determined in a time period of 2 to 4 hours. 8. The method of claim 3, wherein administration of a dose of the composition to a human subject provides a mean plasma memantine concentration profile characterized by dC/dT that is 2.1 ng/ml/hr or less, determined in a time period of 0 to 4 hours, and wherein dC/dT is measured in a single-dose human PK study. 9. The method of claim 8, wherein the dC/dT of 2.1 ng/ml/hr or less is determined in a time period of 2 to 4 hours. 10. The method of claim 1, wherein the neurological condition is Alzheimer's disease.