IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0595308
(2004-10-06)
|
등록번호 |
US-8584473
(2013-11-19)
|
우선권정보 |
DE-103 46 793 (2003-10-08) |
국제출원번호 |
PCT/EP2004/011172
(2004-10-06)
|
§371/§102 date |
20060406
(20060406)
|
국제공개번호 |
WO2005/036136
(2005-04-21)
|
발명자
/ 주소 |
- Schon, Uwe
- Zimmermann, Heiko
- Fuhr, Gunter
|
출원인 / 주소 |
- Fraunhofer-Gesellschaft zur Foerderung der angewandten Forschung, e.V.
|
대리인 / 주소 |
Caesar, Rivise, Bernstein, Cohen & Pokotilow, Ltd.
|
인용정보 |
피인용 횟수 :
0 인용 특허 :
8 |
초록
▼
The invention relates to a cooling apparatus, especially for cryogenically preserving biological samples, comprising a duct (5) for delivering a coolant (3) to a cooling chamber (1), a heater (6) that has an adjustable first heating performance (P2) for heating the coolant (3) delivered to the cooli
The invention relates to a cooling apparatus, especially for cryogenically preserving biological samples, comprising a duct (5) for delivering a coolant (3) to a cooling chamber (1), a heater (6) that has an adjustable first heating performance (P2) for heating the coolant (3) delivered to the cooling chamber (1), a first temperature sensor (8-10) for measuring the temperature (T2-T4) in the cooling chamber (1), a second temperature sensor (7) for measuring the temperature (T1) of the coolant (3) delivered to the cooling chamber (1), and a regulator (11) for regulating the temperature. Said regulator (11) is embodied as a multiple regulator which detects several temperatures (T1-T4) as control variables and/or adjusts several heating performances (P1, P2) as manipulated variables. The invention further relates to a corresponding operating method.
대표청구항
▼
1. Cooling equipment comprising: a) a cooling agent storage container housing a cooling agent;b) a cooling agent supply line connected to the cooling agent storage container for supplying the cooling agent to a non-recirculating cooling chamber, said cooling chamber having an open bottom with an ope
1. Cooling equipment comprising: a) a cooling agent storage container housing a cooling agent;b) a cooling agent supply line connected to the cooling agent storage container for supplying the cooling agent to a non-recirculating cooling chamber, said cooling chamber having an open bottom with an opening to cool an item positioned adjacent the opening of the cooling chamber;c) a heater with an adjustable first heating performance for heating the cooling agent supplied to the cooling chamber, the heater integrated in the cooling agent supply line;d) an evaporator in the cooling agent storage container with an adjustable second heating performance for evaporating the cooling agent present in the cooling agent storage container;e) a first temperature sensor for measuring a chamber temperature in the cooling chamber;f) a second temperature sensor for measuring an agent temperature of the cooling agent supplied to the cooling chamber; andg) a controller for temperature control, the controller having an input side and an output side, the input side connected to the first temperature sensor and the second temperature sensor, the output side connected to the heater and the evaporator,wherein the controller: (i) is adapted to detect several temperatures as control variables; (ii) is a multiple controller adjusting the first heating performance and the second heating performance as manipulated variables. 2. The cooling equipment according to claim 1, wherein the temperature sensors are arranged in a spatially distributed manner for measuring a spatial distribution of temperature. 3. The cooling equipment according to claim 1, wherein at least one of the temperature sensors is a thermocouple and at least one of the temperature sensors is a temperature-dependent electrical resistor. 4. The cooling equipment according to claim 1, wherein the cooling agent is nitrogen. 5. The cooling equipment according to claim 1, wherein the first temperature sensor and the second temperature sensor are connected to storage equipment that stores temperature courses. 6. The cooling equipment according to claim 1, wherein the cooling agent supply line is adapted to empty via a diffuser into the cooling chamber. 7. The cooling equipment according to claim 1, wherein the cooling agent supply line is adapted to empty laterally into the cooling chamber. 8. The cooling equipment according to claim 7, wherein the cooling agent supply line is adapted to empty into the cooling chamber only on one side of the cooling chamber. 9. The cooling equipment according to claim 1, wherein the cooling agent supply line is adapted to empty into the cooling chamber at a top of the cooling chamber. 10. The cooling equipment according to claim 1, wherein the cooling chamber is portable. 11. The cooling equipment according to claim 1, wherein the first temperature sensor is arranged inside the cooling chamber and spaced from a wall of the cooling chamber. 12. The cooling equipment according to claim 11, wherein the first temperature sensor is fastened to the cooling chamber by a holding member extending into the cooling chamber. 13. The cooling equipment according to claim 11, wherein the first temperature sensor is attached to one of a sample and a sample holder. 14. The cooling equipment according to claim 1, wherein the first temperature sensor is connected to a transponder that transmits a measured temperature in a wireless manner to the controller. 15. The cooling equipment according to claim 14, wherein the transponder is selected from the group consisting of a radio transponder, an ultrasonic transponder, an optical transponder and an infrared transponder. 16. An operating method for cooling equipment, said method comprising the following steps: a) introducing a cooling agent into a non-recirculating cooling chamber for cooling cooled material, the non-recirculating cooling chamber having an open bottom with an opening to cool an item positioned adjacent the opening of the non-recirculating cooling chamber;b) heating the cooling agent prior to the introducing step with an adjustable first heating performance;c) measuring an agent temperature of the heated cooling agent;d) measuring of a chamber temperature in the non-recirculating cooling chamber; ande) controlling at least one of the agent temperature and the chamber temperature in that both temperatures are detected as control variables, including controlling the adjustment of a second heating performance as another manipulated variable in addition to controlling the adjustment of the first heating performance; andf) evaporating the liquid cooling agent in a cooling agent storage container with an evaporator having the adjustable second heating performance to provide an evaporated cooling agent as the cooling agent. 17. The operating method according to claim 16, further comprising the following steps: g) heating the evaporated cooling agent prior to the introducing step with the adjustable first heating performance; andh) multiple controlling of the first heating performance and of the second heating performance. 18. The operating method according to claim 16, further comprising the following steps: g) measuring of several spatially distributed temperatures inside the cooling chamber; andh) multiple controlling of the first heating performance and of the second heating performance as a function of the different temperatures inside the cooling chamber. 19. The operating method according to claim 16, further comprising the following steps: g) measuring with a thermocouple one of the chamber temperature and the agent temperature prior to the introducing step;h) measuring with a temperature-dependent resistor the other one of the chamber temperature and the agent temperature prior to the introducing step; andi) multiple controlling of the first heating performance and of the second heating performance as a function of temperatures measured by the thermocouple and of temperatures measured by the temperature-dependent resistor. 20. The operating method according to claim 16, further comprising the following steps: g) setting a target value in the cooling chamber,h) controlling the agent temperature of the cooling agent entering into the cooling chamber in accordance with the target value set for the cooling chamber by adjusting the first heating performance. 21. The operating method according to claim 20, wherein the agent temperature of the cooling agent entering into the cooling chamber is controlled to the target value for the chamber temperature in the cooling chamber. 22. A method of cryopreserving a biological sample comprising cooling the biological sample in the cooling equipment according to claim 1. 23. The cooling equipment according to claim 1, wherein the cooling chamber is bell shaped. 24. The cooling equipment according to claim 1, wherein said cooling equipment is a non-recirculating cooling agent apparatus. 25. The cooling equipment according to claim 1, wherein said cooling chamber is open at its bottom for communication of the cooling agent to the atmosphere beyond the cooling equipment to reach and cool the item. 26. The operating method according to claim 16, wherein said cooling equipment is a non-recirculating cooling agent apparatus. 27. The operating method according to claim 16, further comprising introducing the cooling agent to the atmosphere beyond the cooling equipment to reach and cool the item. 28. Cooling equipment comprising: a) a cooling agent storage container housing a cooling agent;b) a cooling chamber in communication with the cooling agent storage container, said cooling chamber having an open bottom with an opening to cool an item positioned adjacent the opening of the cooling chamber;c) a cooling agent supply line connected to the cooling agent storage container for supplying the cooling agent to a cooling chamber;d) an antechamber in fluid communication between the cooling agent supply line and the cooling chamber, said antechamber including a diffuser spatially diffusing the cooling agent directly from the cooling agent supply line into distinct channels for supply to the cooling chamber;e) a heater with an adjustable first heating performance for heating the cooling agent supplied to the cooling chamber, the heater integrated in the cooling agent supply line;f) an evaporator in the cooling agent storage container with an adjustable second heating performance for evaporating the cooling agent present in the cooling agent storage container;g) a first temperature sensor for measuring a chamber temperature in the cooling chamber;h) a second temperature sensor for measuring an agent temperature of the cooling agent supplied to the cooling chamber; andi) a controller for temperature control, the controller having an input side and an output side, the input side connected to the first temperature sensor and the second temperature sensor, the output side connected to the heater and the evaporator, wherein the controller is adapted to detect several temperatures as control variables, and to adjust the first heating performance and the second heating performance as manipulated variables.
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