초록 ▼

Devices and methods are provided for extracting and macerating tissue, and optionally for depositing the tissue onto a tissue scaffold. The device generally includes an outer tube having a substantially open distal end that is adapted to be placed on and preferably to form a seal with a tissue surfa

Devices and methods are provided for extracting and macerating tissue, and optionally for depositing the tissue onto a tissue scaffold. The device generally includes an outer tube having a substantially open distal end that is adapted to be placed on and preferably to form a seal with a tissue surface, and a shaft rotatably disposed within the outer tube and movable between a first, proximal position in which the shaft is fully disposed within the outer tube, and a second, distal position in which a portion of a distal end of the shaft extends through the opening in the distal end of the outer tube. The device also includes a tissue harvesting tip formed on the distal end of the shaft that is effective to excise a tissue sample when the shaft is moved to the distal position, and a cutting member that is coupled to the shaft at a position proximal to the tissue harvesting tip. The cutting member is effective to macerate a tissue sample excised by the tissue harvesting tip.

대표청구항 ▼

1. A tissue extraction and maceration device, comprising: a housing having proximal and distal ends;an outer tube fixedly coupled to and extending distally from the housing and having a substantially open distal end configured to be placed on a tissue surface;a shaft rotatably disposed within the ou

1. A tissue extraction and maceration device, comprising: a housing having proximal and distal ends;an outer tube fixedly coupled to and extending distally from the housing and having a substantially open distal end configured to be placed on a tissue surface;a shaft rotatably disposed within the outer tube and having proximal and distal ends, the shaft being slidably movable relative to the outer tube between a proximal position in which the shaft is fully disposed within the outer tube and a distal position in which a portion of the distal end of the shaft extends beyond the open distal end of the outer tube;a tissue harvesting tip formed on the distal end of the shaft, the tissue harvesting tip having a plurality of cutting teeth configured to excise a tissue sample; anda tissue collection device coupled to the housing and in fluid communication with the outer tube such that tissue excised by the tissue harvesting tip is delivered to the tissue collection device. 2. The device of claim 1, further comprising a tissue scaffold disposed within the tissue collection device and configured to receive tissue excised by the tissue harvesting tip. 3. The device of claim 1, wherein the tissue harvesting tip is substantially cylindrical. 4. The device of claim 1, wherein the substantially open distal end of the outer tube is configured to form a seal with a tissue surface. 5. The device of claim 1, wherein the tissue harvesting tip is configured to excise a predetermined volume of tissue. 6. The device of claim 5, wherein the predetermined volume of tissue, per tissue sample, is in the range of about 0.5 cm3 to 1.5 cm3. 7. The device of claim 5, wherein the predetermined volume of tissue, per tissue sample, is about 0.9 cm3. 8. The device of claim 1, wherein the tissue harvesting tip has a plurality of openings formed therein. 9. The device of claim 1, further comprising a driver mechanism coupled to the housing and to the proximal end of the shaft. 10. The device of claim 9, wherein the driver mechanism is effective to rotate the shaft at a speed in the range of about 100 to 5000 rpm. 11. The device of claim 1, wherein the substantially open distal end of the outer tube is defined by an edge wall that is at an angle with respect to a longitudinal axis of the outer tube. 12. The device of claim 11, wherein the angle is in the range of about 30° to 75°. 13. The device of claim 11, wherein the angle is about 40°. 14. The device of claim 1, wherein the tissue harvesting tip is hollow. 15. The device of claim 1, wherein the tissue collection device is configured to deposit the tissue sample onto a tissue scaffold for subsequent growth. 16. The device of claim 1, further comprising a biasing element effective to bias the shaft to the proximal position. 17. The device of claim 16, further comprising a trigger mechanism connected to the shaft, wherein, upon actuation, the trigger mechanism is effective to overcome the biasing force to move the shaft from the proximal position to the distal position.