A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive sp
A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible.
대표청구항▼
1. An analyte measurement system, comprising: at least one sensor introducer;a first electrochemical sensor having at least one electrode with an analyte response enzyme thereon, the first electrochemical sensor coupleable to the at least one sensor introducer for positioning at least a portion of t
1. An analyte measurement system, comprising: at least one sensor introducer;a first electrochemical sensor having at least one electrode with an analyte response enzyme thereon, the first electrochemical sensor coupleable to the at least one sensor introducer for positioning at least a portion of the first electrochemical sensor under a skin surface;a second electrochemical sensor having at least one electrode with an analyte response enzyme thereon, the second electrochemical sensor coupleable to the at least one sensor introducer for positioning at least a portion of the second electrochemical sensor under a skin surface; anda device configured to normalize a signal obtained from the first electrochemical sensor with respect to a signal obtained from the second electrochemical sensor, to determine a standard deviation for a difference between the normalized signal of the first electrochemical sensor and the signal obtained from the second electrochemical sensor, to reject the signals of the first electrochemical sensor and the second electrochemical sensor that differ by more than the standard deviation, and to calibrate the signal obtained from the first electrochemical sensor based on a calibration factor. 2. The system of claim 1 wherein at least one electrode of the one or more of the first sensor or the second sensor comprises gold, platinum, palladium, or carbon. 3. The system of claim 1 wherein the signal from the first electrochemical sensor is calibrated using a blood sample. 4. The system of claim 1 wherein the signal from the first electrochemical sensor is calibrated using single point calibration. 5. The system of claim 1 wherein the analyte is glucose. 6. The system of claim 1 wherein at least one of the first electrochemical sensor and the second electrochemical sensor is implanted. 7. The system of claim 6 wherein the at least one of the first electrochemical sensor and the second electrochemical sensor is implanted subcutaneously. 8. The system of claim 1 wherein at least the one electrode of at least one of the first electrochemical sensor or the second electrochemical sensor is implanted. 9. A method, comprising: positioning, using a sensor introducer, at least a portion of at least one electrode of a first electrochemical sensor having analyte response enzyme thereon, in fluid contact with interstitial fluid, the first electrochemical sensor coupleable to the sensor introducer;positioning, using the sensor introducer, at least a portion of at least one electrode of a second electrochemical sensor having analyte response enzyme thereon, in fluid contact with interstitial fluid, the second electrochemical sensor coupleable to the sensor introducer; normalizing, using a device, a signal obtained from the first electrochemical sensor with respect to a signal obtained from the second electrochemical sensor;determining, using the device, a standard deviation for a difference between the normalized signal of the first electrochemical sensor and the signal obtained from the second electrochemical sensor;rejecting, using the device, the signals of the first electrochemical sensor and the second electrochemical sensor that differ by more than the standard deviation; andcalibrating, using the device, the signal obtained from the first electrochemical sensor based on a calibration factor. 10. The method of claim 9 further including determining whether at least one of the signal obtained from the first electrochemical sensor or the signal obtained from the second electrochemical sensor is valid based on the comparison. 11. The method of claim 9 further including measuring an analyte level of the interstitial fluid. 12. The method of claim 11 wherein measuring the analyte level includes measuring a glucose level of the interstitial fluid. 13. The method of claim 9 further including calibrating at least one of the signal obtained from the first electrochemical sensor or the signal obtained from the second electrochemical sensor using a blood sample. 14. The method of claim 9 further including calibrating using single point calibration at least one of the signal obtained from the first electrochemical sensor or the signal obtained from the second electrochemical sensor. 15. The method of claim 9, wherein the first and second electrochemical sensors are positioned at different areas of a body. 16. The method of claim 9, wherein the first and second electrochemical sensors are positioned at substantially the same area of a body. 17. The system of claim 1, wherein the calibration factor is based on at least one signal from one of the first electrochemical sensor or the second electrochemical sensor and a glucose level from a blood sample. 18. The system of claim 1 wherein the device is configured to validate the signal from the second electrochemical sensor based on the signal from the first electrochemical sensor. 19. The system of claim 1 wherein the device is configured to validate a calibrated signal from the second electrochemical sensor based on the signal from the first electrochemical sensor. 20. The system of claim 1 wherein the device is configured to validate the signal from the second electrochemical sensor based on the calibrated signal from the first electrochemical sensor. 21. The system of claim 1 wherein the device is configured to validate a calibrated signal from the second electrochemical sensor based on the calibrated signal from the first electrochemical sensor.
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