IPC분류정보
| 국가/구분 |
United States(US) Patent
등록
|
| 국제특허분류(IPC7판) |
|
| 출원번호 |
US-0447143
(2007-10-26)
|
| 등록번호 |
US-8592220
(2013-11-26)
|
| 국제출원번호 |
PCT/US2007/082685
(2007-10-26)
|
| §371/§102 date |
20100215
(20100215)
|
| 국제공개번호 |
WO2008/052168
(2008-05-02)
|
|
발명자
/ 주소 |
- Bergh, H. Sam
- Wells, Jason
- Wong, Victor
- Gallipeo, John
- Van Erden, Lynn
- Volpe, Anthony F.
- Maag, Jeffrey
|
| 출원인 / 주소 |
|
| 인용정보 |
피인용 횟수 :
0 인용 특허 :
72 |
초록
▼
The present invention discloses an apparatus and method for rapid analysis of members of a combinatorial library. The apparatus includes a plurality of reactor vessels for containing individual library members, a fluid handling system that apportions a test fluid about equally between each of the ve
The present invention discloses an apparatus and method for rapid analysis of members of a combinatorial library. The apparatus includes a plurality of reactor vessels for containing individual library members, a fluid handling system that apportions a test fluid about equally between each of the vessels and a housing for enclosing the reactor vessels, the housing defining a pressure chamber, wherein the housing is configured to sustain a pressure substantially above atmospheric pressure. This allows for simultaneous screening of library members at high pressure by providing a small pressure differential on reactor components. The disclosed apparatus is especially useful for screening library members based on their ability to catalyze the conversion of fluid reactants.
대표청구항
▼
1. A method of screening a plurality of materials, the method comprising: confining the plurality of materials in a plurality of vessels, each material of the plurality of materials being confined in a separate vessel of the plurality of vessels;enclosing the plurality of vessels in a chamber, the c
1. A method of screening a plurality of materials, the method comprising: confining the plurality of materials in a plurality of vessels, each material of the plurality of materials being confined in a separate vessel of the plurality of vessels;enclosing the plurality of vessels in a chamber, the chamber further enclosing a flow splitting device;supplying a gas into the chamber to pressurize the chamber to a first pressure above an atmospheric pressure, wherein the flow splitting device and each of the plurality of vessels are subjected to the first pressure;contacting each of the plurality of materials with a test fluid by flowing the test fluid from the flow splitting device and into each of the vessels under reaction conditions comprising a second pressure above the atmospheric pressure in each of the vessels during the contacting step, the second pressure being different from the first pressure, the test fluid being different from the gas used to pressurize the chamber;detecting changes in the test fluid following contact with each of the plurality of materials; andrelating changes in the test fluid to a property of each of the plurality of materials. 2. The method of claim 1, wherein the plurality of vessels comprises at least four vessels. 3. The method of claim 1, wherein the plurality of vessels comprises at least sixteen vessels. 4. The method of claim 1, wherein the detecting step comprises detecting changes with an infrared spectrometer. 5. The method of claim 1, wherein the detecting step comprises detecting changes with an FTIR spectrometer. 6. The method of claim 1, wherein the detecting step comprises detecting changes with a mass spectrometer. 7. The method of claim 1, wherein the first pressure is greater than 50 psi. 8. The method of claim 1, wherein the first pressure is greater than 200 psi. 9. The method of claim 1, wherein the first pressure is greater than 1000 psi. 10. The method of claim 1, wherein a difference between the first pressure in the chamber and the second pressure in the vessels during the contacting step is less than 200 psi. 11. The method of claim 1, wherein a difference between the first pressure in the chamber and the second pressure in the vessels during the contacting step is less than 50 psi. 12. The method of claim 1, wherein the reaction conditions further comprise a temperature greater than 100° C. 13. The method of claim 1, wherein the reaction conditions further comprise a temperature greater than 300° C. 14. The method of claim 1, wherein the detecting step comprises detecting changes in the test fluid using at least one of gas chromatography, mass spectroscopy, visible spectroscopy, ultraviolet spectroscopy, and infrared spectroscopy. 15. The method of claim 1, wherein the property is a catalytic property of each of the plurality of materials. 16. The method of claim 1, wherein the chamber further encloses an exit volume control comprising a sample bypass and one or more outlet conduits. 17. The method of claim 1, wherein a difference between the second pressure and the first pressure is less than a difference between the first pressure and the atmosphere. 18. The method of claim 1, wherein the flow splitting device is a microfluidic distribution manifold. 19. The method of claim 1, wherein each of the plurality of vessels receives a same amount of the test fluid. 20. The method of claim 1, wherein the detecting changes in the test fluid comprises flowing the test fluid into a detector, the detector being positioned outside of the chamber and exposed to the atmospheric pressure. 21. The method of claim 1, wherein the contacting each of the plurality of materials with the test fluid comprises flowing the test fluid from a manifold connected to one or more reactant reservoirs, the manifold and the one or more reactant reservoirs being positioned outside of the chamber and exposed to the atmospheric pressure. 22. The method of claim 1, wherein the chamber comprises an inlet port for pressurizing the chamber to the first pressure, the inlet port being connected to an external pressure source. 23. The method of claim 1, further comprising maintaining a pressure differential between the first pressure and the second pressure within a predetermined range using a pressure controller. 24. The method of claim 23, wherein the first pressure is automatically adjusted based on changes to the second pressure in order to maintain the pressure differential within predetermined range. 25. The method of claim 23, wherein the pressure differential is maintained within predetermined range during supplying the gas into the chamber to pressurize the chamber to the first pressure. 26. The method of claim 23, wherein the pressure differential is maintained within predetermined range at all times. 27. The method of claim 1, wherein the chamber comprises a base, a cover, and one or more fasteners for connecting the base and the cover and for maintaining the first pressure within the chamber. 28. The method of claim 1, wherein the chamber comprises one of 17-4PH/H1100 stainless steel, 17-4PH/H1150 stainless steel, and 6AI-4V titanium.
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