A method for coating catheter balloons with a defined amount of a pharmacologically active agent, uses a coating device having a volume measuring device for releasing a measurable amount of a coating solution by means of a dispensing device specifically onto the surface of the catheter balloon.
대표청구항▼
1. A method for coating a catheter balloon with a defined amount of a pharmacologically active agent, wherein the coating method uses a coating device with a volume measuring device for releasing a measurable amount of a coating solution by means of a dispensing device specifically in liquid contact
1. A method for coating a catheter balloon with a defined amount of a pharmacologically active agent, wherein the coating method uses a coating device with a volume measuring device for releasing a measurable amount of a coating solution by means of a dispensing device specifically in liquid contact with the surface of the catheter balloon, wherein the coating solution comprises at least one pharmacologically active agent. 2. The method according to claim 1, wherein the dispensing device is a nozzle, a plurality of nozzles, a thread, a mesh of threads, a piece of textile, a leather strip, a sponge, a ball, a syringe, a needle, a cannula or a capillary. 3. The method according to claim 1, wherein the coating method is a squirting method, a pipetting method, a capillary method, a fold spray method, a drag method, a thread drag method or roll method. 4. The method according to claim 1, wherein the coating solution contains at least one transport mediator, citrate ester, contrast medium, polymer, polysaccharide, peptide, nucleotide, oil, fat, wax, fatty acid, fatty acid ester, hydrogel, salt, solvent, pharmacologically acceptable excipient or a mixture of the aforementioned substances. 5. The method according to claim 1, wherein the coating solution comprises at least one citrate ester. 6. A method according to claim 5, wherein the citrate ester is acetyl tributyl citrate or acetyl triethyl citrate or a citrate ester of the formula wherein R, R′, and R″ are independently from each other hydrogen or an alkyl, arylalkyl or cycloalkyl residue which are linear or branched, saturated or unsaturated, and unsubstituted or substituted with at least one functional group. 7. A method according to claim 6, wherein the at least one active agent comprises paclitaxel or rapamycin. 8. A method for coating a catheter balloon with a defined amount of a pharmacologically active agent, the method, comprising: a) providing a catheter balloon in a folded, partially inflated or completely inflated state,b) providing a coating device with a dispensing device,c) dispensing a measured amount of a coating solution from the dispensing device;d) establishing a liquid interface between the dispensing device and the balloon through the dispensed coating solution, wherein the dispensed coating solution contacts the dispensing device and balloon,e) providing relative motion between the dispensing device and the surface of the catheter balloon to be coated while maintaining a constant volume of the coating solution at a the liquid interface between the dispensing device and the balloon and without the dispensing device itself contacting the surface of the catheter balloon, andf) redosing the coating solution so that the volume of the coating solution at the liquid contact substantially maintains a constant volume of the coating solution at the liquid contact between the dispensing device and the balloon. 9. The method according to claim 8, wherein specifically only the folds of the catheter balloon are filled by dragging the drop over the opening of the fold. 10. The method according to claim 8, wherein the surface of the catheter balloon is bedewed before coating with a solvent. 11. The method according to claim 8, wherein the dispensing device is a needle, syringe, cannula, pipette or nozzle. 12. The method according to claim 8, wherein the liquid interface is in the form of a drop. 13. A method for coating a catheter balloon with a defined amount of a pharmacologically active agent, the method, comprising: a) providing a catheter balloon in a folded, partially inflated or completely inflated state,b) providing a coating device with a dispensing device in form of a thread, sponge, leather strip or piece of textile,c) providing a coating solution,d) wetting the dispensing device with the coating solution,e) transferring the coating solution from the dispensing device onto the surface of the catheter balloon to be coated, andf) redosing of the coating solution so that a consistent dispense of the coating solution from the dispensing device onto the surface of the catheter balloon to be coated occurs. 14. The method according to claim 13, wherein the transfer of the coating solution from the dispensing device onto the surface of the catheter balloon to be coated is effected according to step e) by dragging the dispensing device over the surface of the catheter balloon to be coated. 15. The method according to claim 13, wherein specifically only the folds of the catheter balloon are filled by dragging the dispensing device over the opening of the fold or through the folds. 16. The method according to claim 13, wherein the surface of the catheter balloon is bedewed before coating with a solvent. 17. The method according to claim 13, wherein the dispensing device comprises a material that doesn't damage the catheter balloon. 18. The method according to claim 13, wherein all folds of the catheter balloon are coated or filled concomitantly. 19. The method according to claim 13, wherein the complete surface of the catheter balloon is coated concomitantly by a plurality of threads, leather strips, a piece of textile or a mesh of threads. 20. A method for coating a catheter balloon with a defined amount of a pharmacologically active agent, the method, comprising: a) providing a coating device with a ballpoint for transferring the coating solution onto the surface of the catheter balloon to be coated,b) providing a coating solution with access to the ballpoint,c) setting the ballpoint of the coating device onto the surface of the catheter balloon to be coated,d) exerting a pressure on the ballpoint of the coating device for enabling the outflow of the coating solution, ande) tracing the surface of the catheter balloon to be coated with the ballpoint thus transferring the coating solution onto the surface of the catheter balloon to be coated. 21. The method according to claim 20, wherein the complete surface of the catheter balloon to be coated is traced and coated by the ball in one pass. 22. The method according to claim 20, wherein the thickness of the layer is controlled through the pressure exerted on the ballpoint and the displacement velocity of the ballpoint over the surface of the catheter balloon to be coated. 23. A device for the coating of surfaces of catheter balloons comprising a coating device with a ballpoint having a feed line for the coating solution onto the ballpoint and a control for setting the ballpoint on the surface of the catheter balloon and for tracing the surface of the catheter balloon to be coated with the ballpoint. 24. The device according to claim 23, wherein the ballpoint comprises a rubber-like material and not of a metal. 25. A coated catheter balloon produced by the method of claim 8. 26. A coated catheter balloon produced by the method of claim 13. 27. A coated catheter balloon produced by the method of claim 20. 28. An apparatus for dispensing a coating solution on the surface of a catheter balloon, the apparatus comprising: a volumetric metering dispenser;a coating solution storage container connected to the metering dispenser;an apparatus that rotates a catheter having said catheter balloon thereon around its longitudinal axis and provides relative movement between the catheter balloon and the metering dispenser in the direction of the longitudinal axis of the balloon; andwherein the metering dispenser includes a wettable flexible tail that contacts the medical device to transfer the coating solution. 29. A method for preparing a substantially uniform coated medical device, comprising: (1) preparing a coating solution comprising a solvent, a therapeutic agent, and an additive which is a transport agent, citrate ester, contrast medium, polymer, polysaccharide, peptide, nucleotide, oil, fat, wax, fatty acid, fatty acid ester, hydrogel, salt, solvent, pharmacologically acceptable adjuvant or a mixture of aforesaid substances;(2) loading a metering dispenser with the coating solution;(3) rotating the medical device about the longitudinal axis of the medical device and providing relative linear movement between the catheter balloon and the metering dispenser in the direction of the longitudinal axis of the medical device;(4) dispensing the coating solution from the metering dispenser onto a surface of the medical device and flowing the coating solution on the surface of the medical device while the medical device is rotating and said relative linear movement is provided; and(5) evaporating the solvent, forming a substantially uniform coating layer on the medical device. 30. The method according to claim 29, wherein the medical device is a catheter balloon. 31. The method according to claim 29, wherein the metering dispenser comprises a dispensing tip, wherein the dispensing tip includes a tip and a flexible tail, and wherein in step (4) the method further comprises dispensing the coating solution from the metering dispenser to the flexible tail and flowing the coating solution from the flexible tail onto the surface of the medical device while the medical device is rotating and/or linearly moving. 32. The method of claim 29, wherein the metering device comprises a syringe or pipette. 33. The method according to claim 29, wherein steps (2), (3), (4) and (5) occur concomitantly.
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Wolinsky Harvey (New York NY) King Spencer L. (Atlanta GA) Barbere Michael D. (Dunstable MA), Catheter and method for locally applying medication to the wall of a blood vessel or other body lumen.
Bacher Peter (Nurnberg DEX) Walenga Jeanine M. (Lombard IL), Catheter and method for the prevention and/or treatment of stenotic processes of vessels and cavities.
Lindall Arnold W. (1150 Nordic Ave. North ; P.O. Box 187 Stillwater MN 55082), Catheter system for controllably releasing a therapeutic agent at a remote tissue site.
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Brem Henry (Lutherville MD) Langer Robert S. (Newton MA) Domb Abraham J. (Efrat ILX), Controlled local delivery of chemotherapeutic agents for treating solid tumors.
Brem Henry (Lutherville MD) Langer Robert S. (Newton MA) Domb Abraham J. (Efrat ILX), Controlled local delivery of chemotherapeutic agents for treating solid tumors.
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Crocker Michael (Mission Viejo CA) Henson Michael (Pleasanton CA) Chum Muny (Santa Ana CA), Delivery and balloon dilatation catheter and method of using.
Crocker Michael D. (Mission Viejo CA) Henson Michael R. (Pleasonton CA) Chum Muny (Santa Ana CA), Drug delivery and dilatation catheter having a reinforced perfusion lumen.
Shapland James E. (Shoreview MN) Knudson Mark B. (Shoreview MN) Shimada Jin (Falcon Heights MN) Hildebrand Keith R. (Houlton WI), Drug delivery apparatus and method.
Amundson Rodney R. (Lindstrom MN) Hull Vincent W. (Ham Lake MN) Dror Michael (Edina MN) Schwartz Robert S. (Rochester MN), Drug delivery balloon catheter with line of weakness.
Harrison Kent D. (Brooklyn Park MN) Hendrickson Gary L. (Big Lake MN) Holman Thomas J. (Minneapolis MN) Lafontaine Daniel M. (Plymouth MN) Miller Matthew J. (White Bear Lake MN) Robinson David B. (Ch, Drug delivery catheter with manifold.
Nicholas Peter M. (South Dartmouth MA) Sahatjian Ronald A. (Lexington MA) Barry James J. (Marlborough MA), Drug treatment of diseased sites deep within the body.
Herweck, Steve A.; Gingras, Peter H.; Martakos, Paul; Karwoski, Theodore, Expandable fluoropolymer device for delivery of therapeutic agents and method of making.
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Abele John E. (Concord MA) Heath Kevin R. (Providence RI) Landman Mark S. (Sharon MA) McLaughlin Paul D. (Scituate MA), Guidewire for crossing occlusions in blood vessels.
Richard,Robert E.; Strickler,Frederick H., Implantable or insertable medical devices containing graft copolymer for controlled delivery of therapeutic agents.
Schwartz Robert S. (Rochester MN) Bresnahan John (Rochester MN) Bergman Rebecca M. (North Oaks MN) Coury Arthur J. (St. Paul MN) Lindell Elaine (Blaine MN) Hull Vincent W. (Fridley MN) Dror Michael (, Intravascular radially expandable stent.
Brown ; III Charles L. ; Crawford Neville,GBX ; Freear Steven,GBX, Iontophoresis, electroporation and combination catheters for local drug delivery to arteries and other body tissues.
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Williams, Simon F.; Martin, David P.; Gerngross, Tillman; Horowitz, Daniel M., Medical device containing polyhydroxyalkanoate treated with oxidizing agent to remove endotoxin.
Norton William J. (Berkeley Heights NJ), Medical tubing having exterior hydrophilic coating for microbiocide absorption therein and method for using same.
Klein Enrique J. (Los Altos CA) Bajor Jordan (Palo Alto CA) Alba Paul (San Jose CA) Kaplan Aaron V. (Los Altos CA), Method and apparatus for providing external perfusion lumens on balloon catheters.
Shapland James E. (Shoreview MN) Hildebrandt Keith R. (Houlton WI) Knudson Mark B. (Shoreview MN), Method for iontophoretically delivering drug adjacent to a heart.
Amundson Rodney R. (Lindstrom MN) Hull Vincent W. (Ham Lake MN) Dror Michael (Edina MN) Schwartz Robert S. (Rochester MN), Method for making a drug delivery balloon catheter.
Schwartz Abraham (Durham NC) Graper Jane (Durham NC) Williams Joel (Cary NC), Method of applying a hydrophilic coating to a polymeric substrate and articles prepared thereby.
Ferguson Robert D. G. (Memphis TN) Tartaglino Sandra G. (Canton MA), Method of delivering a therapeutic agent or diagnostic device using a micro occlusion balloon catheter.
Machold Timothy R. (Moss Beach CA) Robinson Janine C. (Half Moon Bay CA) Michaels Mary B. (Sunnyvale CA) Sirhan Motasim M. (Sunnyvale CA), Method of delivery therapeutic or diagnostic liquid into tissue surrounding a body lumen.
Anderson Jere R. (Newburyport MA) Jandris Louis J. (Georgetown MA) Barbere Michael D. (Dunstable MA) Murphy Richard T. (Dracut MA 4), Method of making a distensible dilatation balloon using a block copolymer.
Fefeu Michel A. (Magny les Hameaux FRX) Perrin Grard (Chatenois les Forges FRX), Method of manufacturing a hollow shaft with internal swellings of revolution and shaft obtained by this method.
Kresse Mayk (Berlin DEX) Lawaczeck Rudiger (Berlin DEX) Pfefferer Detlef (Berlin DEX), Nanocrystalline magnetic iron oxide particles-method for preparation and use in medical diagnostics and therapy.
Lesniak, Christoph; Schiestel, Thomas; Schmidt, Helmut; Jordan, Andreas, Nanoscale particles having an iron oxide-containing core enveloped by at least two shells.
Raad Isaam (Houston TX) Sherertz Robert (Winston-Salem NC), Non-glycopeptide antimicrobial agents in combination with an anticoagulant, an antithrombotic or a chelating agent, and.
Lesniak Christoph,DEX ; Schiestel Thomas,DEX ; Nass Rudiger,DEX ; Schmidt Helmut,DEX, Process for preparing agglomerate-free nanoscalar iron oxide particles with a hydrolysis resistant coating.
Shapland James E. (Shoreview MN) Knudson Mark B. (Shoreview MN) Shimada Jin (Falcon Heights MN) Racchini Joel R. (Edina MN), Simultaneous angioplasty and phoretic drug delivery.
Scott Neal A. (Atlanta GA) Hanson Stephen R. (Stone Mountain GA) King ; III Spencer B. (Atlanta GA) Harker Laurence A. (Atlanta GA), Stent sheath for local drug delivery.
Pinaki Ray ; Vinayak D. Bhat ; Daryush Mirzaee, Substance delivery apparatus and a method of delivering a therapeutic substance to an anatomical passageway.
Ray,Pinaki; Bhat,Vinayak D.; Mirzaee,Daryush, Substance delivery apparatus and a method of delivering a therapeutic substance to an anatomical passageway.
Wu, Steven Z.; Harish, Sameer; Sanders-Millare, Deborra; Guruwaiya, Judy A.; Mirzaee, Daryush; Hossainy, Syed; Chen, Charlene, Surface features of an implantable medical device.
Barnikol,Wolfgang; Burkhard,Oswald; P철tzschke,Harald; Domack,Ulrike; Dinkelmann,Stephanie; Fiedler,Bernd; Manz,Birgit, Synthetic oxygen transport made from cross-linked modified human or porcine haemoglobin with improved properties, method for a preparation thereof from purified material and use thereof.
Flaherty, J. Christopher; Makower, Joshua; Evard, Philip C.; MacAulay, Patrick E.; Whitt, Jason B.; Colloton, Robert C.; Macfarlane, K. Angela, Systems and methods for delivering drugs to selected locations within the body.
Kunz Lawrence L. ; Klein Richard A. ; Reno John M. ; Grainger David J.,GBX ; Metcalfe James C.,GBX ; Weissberg Peter L.,GBX ; Anderson Peter G., Therapeutic inhibitor of vascular smooth muscle cells.
Brisken Axel F. ; McKenzie John R. ; Zuk Robert F. ; Nassi Menahem ; Cowan Mark W. ; Corl Paul D., Therapeutic ultrasonic catheter for delivering a uniform energy dose.
Fearnot Neal E. (West Lafayette IN) Ragheb Anthony O. (West Lafayette IN) Voorhees ; III William D. (West Lafayette IN), Thrombolytic treated intravascular medical device.
Ewing, Benjamin T.; Brucker, Gregory G.; Bednar, Scott A.; Periard, John R.; Sharma, Ashok A.; Savage, Steven D.; Uber, Arthur E.; Dickerson, Brian P., Method of coating a catheter balloon having a fold.
Ewing, Benjamin T.; Brucker, Gregory G.; Bednar, Scott A.; Periard, John R.; Sharma, Ashok A.; Savage, Steven D.; Uber, III, Arthur E.; Dickerson, Brian P., Method of coating a folded catheter balloon.
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