IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0650370
(2009-12-30)
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등록번호 |
US-8602997
(2013-12-10)
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발명자
/ 주소 |
- Banet, Matt
- Dhillon, Marshal
- McCombie, Devin
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출원인 / 주소 |
|
대리인 / 주소 |
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인용정보 |
피인용 횟수 :
12 인용 특허 :
201 |
초록
▼
The present invention provides a technique for continuous measurement of blood pressure based on pulse transit time and which does not require any external calibration. This technique, referred to herein as the ‘Composite Method’, is carried out with a body-worn monitor that measures blood pressure
The present invention provides a technique for continuous measurement of blood pressure based on pulse transit time and which does not require any external calibration. This technique, referred to herein as the ‘Composite Method’, is carried out with a body-worn monitor that measures blood pressure and other vital signs, and wirelessly transmits them to a remote monitor. A network of body-worn sensors, typically placed on the patient's right arm and chest, connect to the body-worn monitor and measure time-dependent ECG, PPG, accelerometer, and pressure waveforms. The disposable sensors can include a cuff that features an inflatable bladder coupled to a pressure sensor, three or more electrical sensors (e.g. electrodes), three or more accelerometers, a temperature sensor, and an optical sensor (e.g., a light source and photodiode) attached to the patient's thumb.
대표청구항
▼
1. A method for monitoring a blood pressure value from a patient, comprising: (a) applying a variable pressure to the patient's arm using a pressure-delivery system;(b) detecting a time-dependent pressure waveform representing the pressure applied to the patient's arm;(c) digitally filtering a porti
1. A method for monitoring a blood pressure value from a patient, comprising: (a) applying a variable pressure to the patient's arm using a pressure-delivery system;(b) detecting a time-dependent pressure waveform representing the pressure applied to the patient's arm;(c) digitally filtering a portion of the time-dependent pressure waveform to determine a processed pressure waveform;(d) analyzing the processed pressure waveform to determine values for systolic blood pressure, diastolic blood pressure, and mean arterial pressure;(e) detecting a first time-dependent waveform comprising a first feature induced by the patient's heartbeat with a first sensor configured to attach to the patient;(f) detecting a second time-dependent waveform comprising a second feature induced by the patient's heartbeat with a second sensor configured to attach to the patient;(g) determining a pulse transit time from a separation in time between the first feature and the second feature;(h) determining a variation in the pulse transit time as a function of the pressure applied to the patient's arm;(i) processing the variation in pulse transit time to determine a relationship between pulse transit time and mean arterial blood pressure using a mathematical model that estimates an effective mean arterial pressure in the patient's arm that varies with pressure applied by the pressure-delivery system,wherein the effective mean arterial pressure is the difference between the mean arterial pressure determined during step (d) and a pressure-induced blood pressure change,wherein the pressure-induced blood pressure change is defined by the following equation or a mathematical derivative thereof: ΔMAP(P)=F×(Papplied−DIAINDEX) where ΔMAP(P) is the pressure-induced blood pressure change,Papplied is pressure applied by the pressure-delivery system during inflation, DIAINDEX is the diastolic pressure determined from the processed pressure waveform, and F is a mathematical constant; and (j) analyzing a pulse transit time determined when no pressure is applied to the patient's arm with the pressure delivery system, the relationship between pulse transit time and mean arterial blood pressure, and the blood pressure values determined from the processed pressure waveform in step (d) to determine a blood pressure value when no pressure is applied to the patient's arm with the pressure delivery system. 2. The method of claim 1, wherein step (b) comprises detecting the time-dependent pressure waveform representing the pressure applied to the patient's arm while the pressure-delivery system is inflating. 3. The method of claim 2, wherein step (c) comprises digitally filtering a portion of the time-dependent pressure waveform measured during inflation to determine the processed pressure waveform. 4. The method of claim 3, wherein step (c) comprises digitally filtering a portion of the time-dependent pressure waveform measured during inflation with: 1) a digital bandpass filter; and then 2) a digital low-pass filter to determine the processed pressure waveform. 5. The method of claim 1, wherein the pressure-delivery system comprises a cuff comprising an inflatable bladder. 6. The method of claim 5, wherein the pressure-delivery system comprises a pneumatic system connected to the cuff and configured to inflate the cuff. 7. The method of claim 1, wherein step (a) is performed once every 4 hours or more. 8. The method of claim 1, wherein step (j) is performed once every 1 second or less. 9. The method of claim 8, wherein step (j) further comprises determining an average pulse transit time from a set of pulse transit times collected over a time period. 10. The method of claim 9, wherein the time period is between 10 and 120 seconds. 11. The method of claim 1, wherein both the first and second sensors are selected from the group comprising an optical sensor, a pressure sensor, an electrical impedance sensor, an ECG waveform sensor, and a transducer.
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