IPC분류정보
국가/구분 |
United States(US) Patent
등록
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국제특허분류(IPC7판) |
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출원번호 |
US-0337544
(2008-12-17)
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등록번호 |
US-8603073
(2013-12-10)
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발명자
/ 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 |
피인용 횟수 :
17 인용 특허 :
197 |
초록
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Systems for removing heat from a subject's subcutaneous lipid-rich regions, such as tissue, organs, cells, and so forth, are described herein. In various embodiments, the system includes a treatment device and a controller for controlling a treatment process. The controller is configured to detect a
Systems for removing heat from a subject's subcutaneous lipid-rich regions, such as tissue, organs, cells, and so forth, are described herein. In various embodiments, the system includes a treatment device and a controller for controlling a treatment process. The controller is configured to detect and compensate for an interruption in the treatment process.
대표청구항
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1. A system for treating a subcutaneous lipid-rich region of a subject, comprising: a treatment device having a cooling plate configured to remove heat from the subcutaneous lipid-rich region of the subject during a treatment process; anda controller in electrical communication with the treatment de
1. A system for treating a subcutaneous lipid-rich region of a subject, comprising: a treatment device having a cooling plate configured to remove heat from the subcutaneous lipid-rich region of the subject during a treatment process; anda controller in electrical communication with the treatment device, the controller having a computer-readable medium containing instructions for performing a process comprising: performing a treatment process of the subcutaneous lipid-rich region with the treatment device to cool the subcutaneous lipid-rich region;detecting an interruption while the treatment device operates to cool the subcutaneous lipid-rich region during the treatment process;performing a recovery process in response to the detected interruption;returning the subcutaneous lipid-rich region of the subject to a condition generally similar to that at a time of the detected interruption; andcontinuing the treatment process to cool the subcutaneous lipid-rich region after performing the recovery process. 2. The system of claim 1 wherein the instructions for performing a recovery process further include instructions for performing a process comprising: determining an elapsed time of the treatment process;deriving an interrupt temperature (Tinterrupt) of the subcutaneous lipid-rich region based on the elapsed time of the treatment process;determining an elapsed time of the interruption;deriving a rewarming temperature (Trewarm) of the subcutaneous lipid-rich region based on the elapsed time of the interruption;calculating a cooling rate ({dot over (Q)}) for the recovery process as follows: Q.=ρVCp(Trewarm-Tinterrupt)πwhere ρ is a density, V is a volume, and Cp is a specific heat capacity of the subcutaneous lipid-rich region; and π is a recovery duration;initiating the recovery process by cooling the subcutaneous lipid-rich region according to the calculated cooling rate;monitoring a rate of change in a temperature at an interface between the heat exchanging device and the subject; andif the monitored rate of change exceeds a threshold, adjusting the calculated cooling rate or the recovery duration based on the monitored rate of change. 3. The system of claim 1 wherein the instructions for performing a recovery process further include instructions for performing a process comprising: determining an interrupt temperature (Tinterrupt) of the subcutaneous lipid-rich region when the treatment process is interrupted;determining a rewarming temperature (Trewarm) of the subcutaneous lipid-rich region based on an elapsed time since the interruption;calculating a cooling rate ({dot over (Q)}) for the recovery process as follows: Q.=ρVCp(Trewarm-Tinterrupt)πwhere ρ is a density, V is a volume, and Cp is a specific heat capacity of the subcutaneous lipid-rich region; and π is a recovery duration. 4. The system of claim 1 wherein the instructions for performing a recovery process further include instructions for performing a process comprising: determining whether the treatment process is resumable;if the treatment process is resumable, performing the recovery process in response to the detected interruption; andif the treatment process is not resumable, initiating a new treatment process. 5. A controller useful for treating a subcutaneous lipid-rich region of a subject, the controller having a computer-readable medium containing instructions for performing a process comprising: activating a cooling plate to remove heat from the subcutaneous lipid-rich region during a treatment process; andwhen the treatment process is interrupted while the cooling plate operates to cool the subcutaneous lipid-rich region, determining a profile for a recovery process to compensate for rewarming of the subcutaneous lipid-rich region of the subject during the interruption. 6. The controller of claim 5 wherein the profile for the recovery process includes at least one of an average cooling rate, a recovery duration, and an expected rate of change for a temperature at an interface between the subject and the cooling plate. 7. The controller of claim 5 wherein the profile for the recovery process includes an average cooling rate ({dot over (Q)}) and a recovery duration (π) related to each other as follows: Q.=ρVCp(Trewarm-Tinterrupt)πwhere ρ is a density, V is a volume, and Cp is a specific heat capacity of the subcutaneous lipid-rich region; Trewarm is a temperature of the subcutaneous lipid-rich region after the interruption; and Tinterrupt is a temperature of the subcutaneous lipid-rich region at the time of the interruption. 8. The controller of claim 5 wherein the profile for the recovery process includes an expected rate of change for a temperature at an interface between the subject and the cooling plate calculated as follows: ΔT=(Trewarm-Tinterrupt)πwhere Trewarm is a temperature of the subcutaneous lipid-rich region after the interruption; Tinterrupt is a temperature of the subcutaneous lipid-rich region at the time of the interruption; and π is a recovery duration. 9. The controller of claim 5 wherein the process further includes: detecting the interruption in the treatment process;determining whether the treatment process is resumable; andif the treatment process is resumable, performing the recovery process according to the determined profile and subsequently continuing the treatment process. 10. The controller of claim 5 wherein the profile for the recovery process includes an expected rate of change for a temperature at an interface between the subject and the cooling plate, and wherein the process further includes: detecting the interruption in the treatment process;determining whether the treatment process is resumable;if the treatment process is resumable, and performing the recovery process according to the determined profile;monitoring the rate of change; andadjusting the profile for the recovery process if the monitored rate of change deviates from the expected rate of change by a preselected amount. 11. The controller of claim 5 wherein the profile for the recovery process includes at least one of an average cooling rate, a recovery duration, and an expected rate of change for a temperature at an interface between the subject and the cooling plate, and wherein the process further includes: detecting the interruption in the treatment process;determining whether the treatment process is resumable; andif the treatment process is resumable, performing the recovery process according to the determined profile;monitoring the rate of change for the temperature at the interface between the subject and the cooling plate; andif the monitored rate of change deviates from the expected rate of change by a preselected amount, performing at least one of increasing a power level to the heat exchanging device and increasing the recovery duration. 12. The controller of claim 5 wherein the process further includes determining an interruption temperature of the subcutaneous lipid-rich region at the time of the interruption and a rewarming temperature of the subcutaneous lipid-rich region after the interruption based on an elapsed time of the treatment process and an elapsed time of the interruption, respectively. 13. The controller of claim 5 wherein the process further includes a database containing lookup tables of temperatures of the subcutaneous lipid-rich region and corresponding cooling and/or rewarming durations, and wherein the process further includes determining an interruption temperature of the subcutaneous lipid-rich region at the time of the interruption and a rewarming temperature of the subcutaneous lipid-rich region after the interruption based on the lookup tables in the database and an elapsed time of the treatment process and an elapsed time of the interruption, respectively. 14. The system of claim 1 wherein the interruption is at least one of detaching of the treatment device from the subject and freezing of adipose tissue of the subject. 15. A system for treating a subcutaneous lipid-rich region of a subject, comprising: a treatment device configured to remove heat from the subcutaneous lipid-rich region of the subject during a treatment process; anda controller in communication with the treatment device and containing instructions for: starting a treatment process by removing heat from the subcutaneous lipid-rich region using the treatment device such that the subcutaneous lipid-rich region is substantially maintained within a treatment temperature range at which lipid rich cells in the subcutaneous lipid-rich region are affected;detecting an interruption of the treatment process before completion of the treatment process;performing a recovery process in response to the detected interruption, the recovery process including cooling the subcutaneous lipid-rich region to return the subcutaneous lipid-rich region to the treatment temperature range; andresuming the treatment process after performing the recovery process by substantially maintaining the subcutaneous lipid-rich region within the treatment temperature range to affect lipid rich cells in the subcutaneous lipid-rich region. 16. The system of claim 15 wherein performing the recovery process includes compensating for warming of the subcutaneous lipid-rich region of the subject after the interruption and before resuming the treatment process. 17. The system of claim 15 wherein the treatment temperature range is about −20° C. to about 20° C. 18. The system of claim 15 wherein performing the recovery process includes determining a profile for operating the treatment device to compensate for warming of the subcutaneous lipid-rich region of the subject to return the subcutaneous lipid-rich region to the treatment temperature range. 19. A system for treating a subcutaneous lipid-rich region of a subject, comprising: a treatment device configured to cool the subcutaneous lipid-rich region of the subject; anda controller in communication with the treatment device and containing instructions for: starting a treatment process by cooling the subcutaneous lipid-rich region using the treatment device such that the subcutaneous lipid-rich region is at a therapeutically effective cooled state;detecting an interruption of heat transfer between the treatment device and the subject before completion of the treatment process;after detecting the interruption, cooling the subcutaneous lipid-rich region such that the subcutaneous lipid-rich region is returned to the therapeutically effective cooled state; andafter returning the subcutaneous lipid-rich region to the therapeutically effective cooled state, continuing the treatment process to substantially maintain the subcutaneous lipid-rich region at the therapeutically effective cooled state to complete the treatment process. 20. The system of claim 19 wherein continuing the treatment process to substantially maintain the subcutaneous lipid-rich region at the therapeutically effective cooled state includes maintaining the subcutaneous lipid-rich region within a temperature range of about −20° C. to about 20° C. 21. The system of claim 19 wherein controller further contains instructions for: determining whether the treatment process is resumable based on the detected interruption;if the treatment process is resumable, cooling the subcutaneous lipid-rich region to perform an uncompleted portion of the treatment process; andif the treatment process is not resumable, initiating a new protocol to complete the treatment process.
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