Compositions and methods for biological remodeling with frozen particle compositions
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-051/00
A61K-009/14
A61K-009/00
출원번호
US-0384201
(2009-03-31)
등록번호
US-8603495
(2013-12-10)
발명자
/ 주소
Boyden, Edward S.
Cook, Daniel B.
Hyde, Roderick A.
Leuthardt, Eric C.
Myhrvold, Nathan P.
Sweeney, Elizabeth A.
Wood, Jr., Lowell L.
출원인 / 주소
The Invention Science Fund I, LLC
인용정보
피인용 횟수 :
1인용 특허 :
129
초록▼
Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particula
Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.
대표청구항▼
1. A frozen particle composition, comprising: one or more frozen particles coated with at least one neuro-muscular toxin and further include at least one biological remodeling agent including collagen and one or more of vitamin A, vitamin C, fibrin, thrombin, hyaluronic acid, hydroxylapatite, kerati
1. A frozen particle composition, comprising: one or more frozen particles coated with at least one neuro-muscular toxin and further include at least one biological remodeling agent including collagen and one or more of vitamin A, vitamin C, fibrin, thrombin, hyaluronic acid, hydroxylapatite, keratin, fibrinogen, hyaluronate, chitin, chitosan, methylcellulose, alginate, cellulose, polyaldehyde glucornate, Factor XIII, Factor XII, silicone, polyurethane, elastin, glycosaminoglycan, poly(alpha-hydroxyacid), or glutaraldehyde;wherein the one or more frozen particles have at least one major dimension of approximately one micrometer or less, approximately one nanometer or less, or any value therebetween. 2. The frozen particle composition of claim 1, wherein the at least one major dimension includes at least one of the radius, diameter, length, width, height, or perimeter. 3. The frozen particle composition of claim 1, further including one or more extracellular matrix components. 4. The frozen particle composition of claim 1, wherein the at least one biological remodeling agent is located in at least one cavity of the frozen particle compositions. 5. The frozen particle composition of claim 1, further including one or more of a blood cell, chondrocyte, endothelial cell, hepatocyte, keratinocyte, myocyte, osteoblast, osteoclast, osteocyte, mesenchymal cell, stem cell, progenitor cell, or fibroblast. 6. The frozen particle composition of claim 1, wherein the collagen includes one or more of Type I collagen, Type II collagen, Type III collagen, Type VII collagen, Type X collagen, elastin fibers, or soluble elastin. 7. The frozen particle composition of claim 1, wherein the biological remodeling agent includes one or more of an angiogenic factor, growth factor, or cytokine. 8. The frozen particle composition of claim 1, further including at least one of a nanoparticle, detection material, sensor, micro-syringe, or circuit. 9. The frozen particle composition of claim 1, the frozen particles further including at least one antimicrobial agent. 10. The frozen particle composition of claim 9, wherein the at least one antimicrobial agent includes at least one antibiotic or anti-fungal agent. 11. The frozen particle composition of claim 9, wherein the at least one antimicrobial agent includes one or more of penicillin, cephalosporin, polymixin, sulfonamide, beta-lactam antibiotic, beta-lactamase inhibitor, enediynes, lincosamide antibiotic, nitroimidazole antibiotic, pleuromutilin antibiotic, polyketide antibiotic, polymyxin antibiotic, polypeptide antibiotic, antimicrobial peptides, quinolone antibiotic, rifamycin antibiotic, sulfonamide antibiotic, tetracycline antibiotic, aminoglycoside antibiotic, macrolide, tetracycline, cyclic lipopeptide, glycylcycline, oxazolidinone, amoxicillin, tobramycin, levofloxacin, gatifloxacin, moxifloxacin, streptomycin, oxytetracycline, chloramphenicol, or ampicillin. 12. The frozen particle composition of claim 1, further including at least one cytotixic agent.
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Cates Michael C. (Solana Beach CA) Hamm Richard R. (San Diego CA) Lewis Michael W. (Wichita KS) Schmitz Wayne N. (St. Louis MO), Method and system for removing a coating from a substrate using radiant energy and a particle stream.
Costantino Henry R. ; Jaworowicz Warren E. ; Tracy Mark A. ; Beganski Christopher P., Method of producing sub-micron particles of biologically active agents and uses thereof.
Cummins Thomas J. (Rochester NY) Ekeze Tobias D. (Rochester NY), Methods of extracting nucleic acids and PCR amplification without using a proteolytic enzyme.
Rhim Won-Kyu (Pasadena CA) Hyson Michael T. (Glendale CA) Chung Sang-Kun (Diamond Bar CA) Colvin Michael S. (Malibu CA) Chang Manchium (Los Angeles CA), Monodisperse, polymeric microspheres produced by irradiation of slowly thawing frozen drops.
Shih, Hong; Leonte, Oana M.; Daugherty, John E.; Huang, Tuochuan; Goldspring, Gregory J.; May, Michael C., On-line chamber cleaning using dry ice blasting.
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Fages Jacques,FRX ; Marty Alain,FRX ; Combes Didier,FRX ; Condoret Jean-Stephane,FRX, Process for treating bone tissue and corresponding implantable biomaterials.
Clauss Steven L. (Manville NJ) Pastel Michael J. (Highland Mills NY) Zawadzki Rainer K. (Wuhan CNX), Stable porfimer sodium compositions and methods for their manufacture.
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Santa Cruz Cathy D. ; Deniston-Korgol Christine L. ; Baugh Barbara I. ; Baugh Alexandria D. ; Baugh Roger D., Weather-proof wrist, forearm, and elbow protectors.
Dean ; Jr. Robert C. (Norwich VT) Silver Frederick H. (Long Valley NJ) Berg Richard A. (Lambertville NJ) Phillips Philip G. (Norwich VT) Runstadler ; Jr. Peter W. (Hanover NH), Weighted collagen microsponge for immobilizing bioactive material.
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