Number coding for identification of subtypes of coded types of solid phase carriers
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
G01N-033/48
G01N-031/00
G06G-007/48
G06G-007/58
출원번호
US-0071055
(2011-03-24)
등록번호
US-8615367
(2013-12-24)
발명자
/ 주소
Seul, Michael
Chau, Chiu Wo
Tan, Enqing
출원인 / 주소
Bioarray Solutions, Ltd.
대리인 / 주소
Womble Carlyle Sandridge & Rice, LLP
인용정보
피인용 횟수 :
0인용 특허 :
464
초록▼
Disclosed is number coding of pairs (“doublets”) or small sets (“multiplets”) of solid phase carriers which provides distinguishable subtypes of a given type of such carriers, where each carrier type is distinguishable on the bases of a different code. Such number coding is useful for augmenting a c
Disclosed is number coding of pairs (“doublets”) or small sets (“multiplets”) of solid phase carriers which provides distinguishable subtypes of a given type of such carriers, where each carrier type is distinguishable on the bases of a different code. Such number coding is useful for augmenting a coding system, such as a color code, and thereby effectively multiplying the number of “colors” (distinguishable sub-types). It can be applied, for example, to determine whether a sample is homozygous or heterozygous at a number of different sites for one of two different alleles, where the same color code is applied for each of the two alleles, and the alleles with the same color code are distinguished by knowing how many carriers are associated with molecules which detect each different allele.
대표청구항▼
1. A method of employing numerical encoding of particles in a bioassay, comprising: providing uniquely color encoded groups of particles having ligands attached to said particles wherein each group of particles comprises two or more subtypes of particles having different ligands attached to said two
1. A method of employing numerical encoding of particles in a bioassay, comprising: providing uniquely color encoded groups of particles having ligands attached to said particles wherein each group of particles comprises two or more subtypes of particles having different ligands attached to said two or more subtypes of particles;wherein the number of each subtype of particles provided has a unique decomposition into one or more summands, such that no partial sum of one or more summands can be obtained in any other way of combining summands, and no summand is itself the sum of two or more of the other summands;conducting an assay by contacting the groups of particles with a sample comprising analytes;determining, for each group of particles, the number of particles generating a positive assay signal, indicating reaction between a ligand and an analyte;comparing, for each group of particles, said number of particles generating a positive assay signal with the number of particles of each subtype; anddetermining, for each group of particles, the analytes present in the sample based on said comparing step. 2. The method of claim 1, wherein the different ligands attached to said two or more subtypes of particles comprise one of four oligonucleotide probes, each probe differing by having one of the nucleotides A, C, G or T in the 3′ terminal position. 3. The method of claim 2 wherein a positive assay signal is generated by an elongation reaction. 4. A method of employing numerical coding of particles, comprising: providing uniquely color encoded groups of particles having peptides or antibodies attached to said particles, wherein each group of particles comprises two or more subtypes of particles having different peptides or antibodies attached to said two or more subtypes of particles;wherein the number of each subtype of particles provided has aunique decomposition into one or more summands, such that no partial sum of one or more summands can be obtained in any other way of combining summands, and no summand is itself the sum of two or more of the other summands;conducting an assay by contacting the groups of particles with a sample comprising analytes;determining for each group of particles, the number of particles generating a positive assay signal, indicating reaction between a peptide or antibody and an analyte;comparing for each group of particles, said number of particles generating a positive assay signal with the number of particles of each subtype; anddetermining for each group of particles, the analytes present in the sample based on said comparing step. 5. The method of claim 4 wherein the ligands comprise peptides and the analytes comprise specific epitopes of auto-antibodies in the sample. 6. The method of claim 5, further comprising adding a secondary detection antibody which binds to auto-antibodies bound to the peptides. 7. The method of claim 4 wherein the color encoded groups comprise different colors corresponding to different groups of peptide ligands, each such group of peptides corresponding to epitopes of a specific autoantibody. 8. The method of claim 4 wherein two or more different types of peptides are attached to beads of the same group.
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Klainer Stanley M. (San Ramon CA) Walt David R. (Lexington MA) Gottlieb Amos J. (San Francisco CA), Surface-bound fluorescent polymers and related methods of synthesis and use.
Albert, Jonathan D.; Comiskey, Barrett; Jacobson, Joseph M.; Zhang, Libing; Loxley, Andrew; Feeney, Robert; Drzaic, Paul; Morrison, Ian, Suspended particle displays and materials for making the same.
Fodor Stephen P. A. (Palo Alto CA) Pirrung Michael C. (Durham NC) Read J. Leighton (Palo Alto CA) Stryer Lubert (Stanford CA), Synthesis and screening of immobilized oligonucleotide arrays.
Dower William J. (Menlo Park CA) Barrett Ronald W. (Sunnyvale CA) Gallop Mark A. (Palo Alto CA) Needels Michael C. (Oakland CA), Synthesizing and screening molecular diversity.
Schulz Donald N. (Annandale NJ) Berluche Enock (Phillipsburg NJ) Maurer John J. (New Providence NJ) Bock Jan (Bridgewater NJ), Tetrapolymers of N-vinyl pyrrolidone/acrylamide/salt of acrylic acid/N-alkyl acrylamide.
Walt David R. (Lexington MA) Bronk Karen S. (Somerville MA), Thin film fiber optic sensor array and apparatus for concurrent viewing and chemical sensing of a sample.
McGuire Kenneth Stephen ; Tweddell ; III Richard ; Hamilton Peter Worthington, Three-dimensional, amorphous-patterned, nesting-resistant sheet materials and method and apparatus for making same.
Lebl Michal ; Lam Kit S. ; Salmon Sydney E. ; Krchnak Victor ; Sepetov Nikolai ; Kocis Peter, Topologically segregated, encoded solid phase libraries comprising linkers having an enzymatically susceptible bond.
Smith, Martin A.; Fomovskaia, Galina N.; Fomovsky, Mikhail A.; Butt, Neil J.; Baker, Matthew, Transfusion medicine leukodepletion filter devices as a source of genetic material for genotyping studies.
Anne R. Kopf-Sill ; Andrea W. Chow ; Peter C. Jann ; Morten J. Jensen ; Michael Spaid ; Colin B. Kennedy ; Michael J. Kennedy, Ultra high throughput microfluidic analytical systems and methods.
Chait, Brian T.; Latimer, Darin R.; Lizardi, Paul M.; Kershnar, Eric R.; Morrow, Jon S.; Roth, Matthew E.; Mattessich, Martin J.; McConnell, Kevin J., Ultra-sensitive detection systems using alterable peptide tags.
Zarling David A. (Menlo Park CA) Rossi Michel J. (Lausanne CHX) Peppers Norman A. (Belmont CA) Kane James (Lawrenceville NJ) Faris Gregory W. (Menlo Park CA) Dyer Mark J. (San Jose CA) Ng Steve Y. (S, Up-converting reporters for biological and other assays using laser excitation techniques.
McCasky Feazel Rhonda J. ; Helentjaris Timothy G. ; Malmberg Sharon E. ; Martin Barry A., Use of selective DNA fragment amplification products for hybridization-based genetic fingerprinting, marker assisted selection, and high-throughput screening.
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