IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0223885
(2007-02-13)
|
등록번호 |
US-8616072
(2013-12-31)
|
국제출원번호 |
PCT/US2007/004139
(2007-02-13)
|
§371/§102 date |
20100809
(20100809)
|
국제공개번호 |
WO2007/095366
(2007-08-23)
|
발명자
/ 주소 |
- Boeke, Jef D.
- Li, Min
- Zhu, Heng
- Long, Shunyou
|
출원인 / 주소 |
- The Johns Hopkins University
|
대리인 / 주소 |
Johns Hopkins Technology Transfer
|
인용정보 |
피인용 횟수 :
0 인용 특허 :
5 |
초록
Provided herein are systems and methods for storage, retrieval and sampling of materials.
대표청구항
▼
1. A system for retrieving a subset of a stored sample, comprising: an automated freezer comprising a dispenser,a climate controlled receiving chamber adjacent to the dispenser,a transfer device within the receiving chamber,a robot operatively connected to the transfer device and positioned to acces
1. A system for retrieving a subset of a stored sample, comprising: an automated freezer comprising a dispenser,a climate controlled receiving chamber adjacent to the dispenser,a transfer device within the receiving chamber,a robot operatively connected to the transfer device and positioned to access the subset of a stored sample,wherein the robot comprises a tip, said tip being selected from the group consisting of a metal tip with high thermal heat capacity, metal pin, a ceramic pin, a hollow pin, and a core sampler for retrieving a portion of a sample, andwherein the tip comprises a volume control mechanism. 2. The system of claim 1, wherein the dispenser communicates with the climate controlled receiving chamber through a port. 3. The system of claim 1, wherein the robot comprises a sample locator or a rotating tip station for maintaining sampling tips at a sampling temperature. 4. The system of claim 3, wherein the sample locator comprises a barcode reader. 5. The system of claim 1, further comprising a tip sterilizer positioned in functional proximity to the robot. 6. The system of claim 1, further comprising one or more destination plates for receiving retrieved samples positioned in functional proximity to the robot. 7. The system of claim 1, wherein the automated freezer is a vertical or horizontal storage freezer. 8. The system of claim 1, wherein the climate controlled receiving chamber comprises one or more of a humidity controller, an atmospheric gas control mechanism, a temperature controlling mechanism, or a reading device to identify the containers as they are inserted into and retrieved from the chamber. 9. A system for retrieving a subset of a stored sample, comprising: an automated freezer comprising a dispenser,a climate controlled receiving chamber adjacent to the dispenser,a transfer device within the receiving chamber,a robot operatively connected to the transfer device and positioned to access the subset of a stored sample, wherein the robot comprises a tip, anda heat sensor to monitor the temperature in the vicinity of the tip. 10. A system for retrieving a subset of a stored sample, comprising: an automated freezer comprising a dispenser,a climate controlled receiving chamber adjacent to the dispenser,a transfer device within the receiving chamber,a robot operatively connected to the transfer device and positioned to access the subset of a stored sample, anda delidder within the receiving chamber. 11. The system of claim 10, wherein the robot comprises a tip. 12. The system of claim 11, wherein the tip is selected from the group consisting of a metal tip with high thermal heat capacity, metal pin, a ceramic pin, a hollow pin, and a core sampler for retrieving a portion of a sample. 13. The system of claim 12, wherein the tip comprises a tip head. 14. The system of claim 12, wherein the tip is disposable. 15. A method for sampling a frozen sample, comprising: retrieving a sample in a container from a freezer,transferring the container to a climate controlled receiving chamber, andsampling the sample with a robot and transferring the container to the freezer. 16. The method of claim 15, further comprising delidding the container in the climate controlled chamber. 17. The method of claim 15, wherein retrieving the sample comprises ejecting the container to an exterior of the freezer for transport to the robot. 18. The method of claim 15, wherein sampling comprises transiently thawing at least a portion of the sample. 19. The method of claim 15, wherein the sample rapidly refreezes upon return to the freezer. 20. The method of claim 15, wherein the container comprises a multiwell plate. 21. The method of claim 20, wherein adjacent samples to the sample being sampled are not thawed. 22. The method of claim 15, further comprising sealing the container with a seal prior to freezing in the freezer a first time. 23. The method of claim 22, wherein the seal comprises a foil seal, a plastic seal, a polymer seal or a septum.
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