Nebuliser for the production of aerosolized medication
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61M-011/00
B05B-017/06
출원번호
US-0833932
(2004-04-27)
등록번호
US-8616195
(2013-12-31)
발명자
/ 주소
Power, John S
Moran, Declan
Devery, Donal
O'Sullivan, Gavan
Fink, James
Smith, Niall
출원인 / 주소
Novartis AG
대리인 / 주소
Janah & Associates, PC
인용정보
피인용 횟수 :
19인용 특허 :
368
초록▼
A nebulizer to deliver a medicament that includes a housing having a reservoir for the medicament, an aerosol generator that can be supplied the medicament from the reservoir, where the generator aerosolizes at least a portion of the medicament into an aerosol, a gas venting inlet to permit a gas to
A nebulizer to deliver a medicament that includes a housing having a reservoir for the medicament, an aerosol generator that can be supplied the medicament from the reservoir, where the generator aerosolizes at least a portion of the medicament into an aerosol, a gas venting inlet to permit a gas to enter the nebulizer and form a mixture with the aerosol, and a passage through which the mixture of the aerosol and the gas is delivered to an outlet port of the nebulizer.
대표청구항▼
1. A nebuliser to deliver a medicament comprising: a housing having a reservoir for the medicament;an aerosol generator comprising a vibratable member having a plurality of apertures extending between a first surface and second surface of the member that can be supplied the medicament from the reser
1. A nebuliser to deliver a medicament comprising: a housing having a reservoir for the medicament;an aerosol generator comprising a vibratable member having a plurality of apertures extending between a first surface and second surface of the member that can be supplied the medicament from the reservoir, wherein the generator aerosolizes at least a portion of the medicament into an aerosol;a gas venting inlet to permit a gas to enter the nebuliser and form a mixture with the aerosol;a passage through which the mixture of the aerosol and the gas is delivered to an outlet port of the nebulizer; anda drive circuit for the aerosol generator;wherein the drive circuit is configured to, substantially throughout aerosolization, repeatedly change a frequency of vibration of the vibratable member between a first frequency and a second frequency. 2. A nebuliser according to claim 1, wherein the medicament is supplied from the reservoir to the aerosol generator by gravitational flow. 3. A nebuliser according to claim 1, wherein the gas venting inlet is located in close proximity to the aerosol generator. 4. A nebuliser according to claim 1, wherein the housing has a baffle to direct the mixture of the gas and the aerosol to the outlet port. 5. A nebuliser according to claim 4, wherein the baffle comprises an inclined surface oriented to cause aerosol to flow through the outlet port. 6. A nebuliser according to claim 4, wherein the baffle is inclined towards the outlet port. 7. A nebuliser according to claim 1, wherein the nebuliser comprises an aerosol rainout trap. 8. A nebuliser according to claim 7, wherein the rainout trap is adjacent to the outlet port. 9. A nebuliser according to claim 1, wherein the aerosol generator has a protector to protect the aerosol generator against physical damage. 10. A nebuliser according to claim 9, wherein the protector comprises an upper protector above the aerosol generator. 11. A nebuliser according to claim 10 wherein the upper protector comprises a mesh. 12. A nebuliser according to claim 9, wherein the protector comprises a lower protector below the aerosol generator. 13. A nebuliser according to claim 12 wherein the lower protector comprises a mesh. 14. A nebuliser according to claim 12, wherein the lower protector is integral with the nebuliser housing. 15. A nebuliser according to claim 1, wherein the nebuliser comprises a respiratory connector configured to connect the outlet port to a respiratory system. 16. A nebuliser according to claim 15, wherein the respiratory connector comprises a mouth piece. 17. A nebuliser according to claim 15, wherein the respiratory connector is selected from a group consisting of a mouthpiece, a face mask, and a nasal piece. 18. A nebuliser according to claim 1, wherein the nebuliser comprises an aerosol generator housing in which the aerosol generator is held. 19. A nebuliser according to claim 18, wherein the aerosol generator housing is fixed to the reservoir. 20. A nebuliser according to claim 1, wherein the apertures in the vibratable member are sized to aerosolize the medicament by ejecting droplets of medicament such that about 70% or more of the droplets by weight have a size in the range from about 1 to about 6 micrometers. 21. A nebuliser according to claim 1, wherein the drive circuit comprises a push-pull resonant power circuit. 22. A nebuliser according to claim 21, wherein the vibratable member comprises a piezoelectric element and the push-pull resonant power circuit comprises an inductive element having an impedance value substantially equal to an impedance of the piezoelectric clement. 23. A nebuliser according to claim 21, wherein the push-pull resonant power circuit comprises an inductive element. 24. A nebuliser according to claim 21, wherein the push-pull resonant power circuit comprises a pair of MOSFET switches operated in an on-off arrangement. 25. A nebuliser according to claim 1, comprising an electrical connector for supplying electrical power to the aerosol generator. 26. A nebuliser according to claim 1, comprising an aerosol generator assembly that includes a power inlet coupled to the aerosol generator, wherein at least a portion of the assembly is encased by an electrically insulating elastomeric casing. 27. A nebuliser according to claim 26, wherein the elastomeric encasing is produced by a process of injection molding. 28. A nebuliser according to claim 1, wherein the nebuliser comprises a drive circuit coupled to the aerosol generator and adapted to be plugged directly to a wall outlet receiving an input of an alternating voltage in the range from about 90V to about 250V at a frequency from about 50 Hz to about 60 Hz, and producing an alternating voltage output at an operating frequency range from about 50 Khz to about 300 Khz. 29. A nebuliser according to claim 28, wherein the drive circuit includes an inductive element having a substantially same impedance of the nebuliser circuit at at least one operating frequency. 30. A nebuliser according to claim 1, wherein the nebuliser comprises a drive circuit coupled to the aerosol generator adapted for use with batteries receiving an input of voltage in the range from 1.5 to 12 Volt and producing an alternating voltage output at an operating frequency range from 50 Khz to 300 Khz. 31. A nebuliser according to claim 30, wherein the drive circuit comprises an inductive element having a substantially same impedance of said nebuliser circuit at at least one operating frequency. 32. A nebuliser according to claim 1, wherein the gas entering the nebuliser comprises air. 33. A method for nebulising a liquid comprising: providing a vibratable thin shell member comprising a front surface, a rear surface and a plurality of tapered apertures extending therebetween, said apertures being tapered to narrow from the rear surface to the front surface;vibrating the thin shell member; andsubstantially throughout nebulisation, repeatedly sweeping a frequency of vibration of the vibrating thin shell member across a delivery range of the vibratable member. 34. A method according to claim 33, wherein changing a frequency of vibration of the vibrating thin shell member comprises changing a drive frequency of a drive circuit that controls the frequency of vibration of the vibrating thin shell, wherein the drive frequency goes from a first drive frequency to a second drive frequency in a plurality of incremental steps. 35. A method according to claim 33, wherein the liquid is a lipid. 36. A method for nebulising a liquid comprising: providing a vibratable thin shell member comprising a front surface and a rear surface and a plurality of tapered apertures extending therebetween, said apertures being tapered to narrow from rear surface, to the front surface;vibrating the thin shell member;substantially throughout nebulisation, repeatedly sweeping a frequency of vibration of the vibrating thin shell member across a delivery range of the vibratable member; andsupplying heat to the liquid. 37. A method according to claim 36, wherein the liquid is a lipid..
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