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A nozzle assembly for a needle-free injection device. The nozzle assembly includes a nozzle body including an injectate chamber and one or more outlet orifices and a plunger configured to move through the injectate chamber toward the one or more outlet orifices. In some embodiments, the plunger incl

A nozzle assembly for a needle-free injection device. The nozzle assembly includes a nozzle body including an injectate chamber and one or more outlet orifices and a plunger configured to move through the injectate chamber toward the one or more outlet orifices. In some embodiments, the plunger includes a first portion and a second portion removably joined by a frangible region. In some embodiments, the plunger includes extensions configured to couple the plunger to a drive assembly of a needle-free injection device.

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1. A nozzle assembly for a needle-free injection device comprising: a nozzle body including an injectate chamber and an outlet orifice; anda plunger configured to move through the injectate chamber toward the outlet orifice, the plunger including a proximal portion, a distal portion and frangible re

1. A nozzle assembly for a needle-free injection device comprising: a nozzle body including an injectate chamber and an outlet orifice; anda plunger configured to move through the injectate chamber toward the outlet orifice, the plunger including a proximal portion, a distal portion and frangible region along which the proximal portion and distal portion are configured to uncouple upon injection;wherein the proximal portion is adapted to rotate relative to and away from the distal portion about a longitudinal axis of the plunger upon injection, the rotation being sufficient to prevent the proximal region from catching on the distal portion when the distal portion is withdrawn;wherein the proximal portion remains in the injectate chamber upon retraction of the distal portion from the injectate chamber. 2. The nozzle assembly of claim 1, wherein the proximal portion is configured to lodge in a proximal end of the injectate chamber, thereby preventing intake of an injectate into the injectate chamber. 3. The nozzle assembly of claim 1, wherein the frangible region is configured to yield in response to a force applied along a longitudinal axis of the plunger. 4. The nozzle assembly of claim 3, wherein a surface of the proximal portion that is proximal to the frangible region is planar and is at an angle relative to the longitudinal axis. 5. The nozzle assembly of claim 4, wherein the surface of the proximal portion guides the region of the distal portion adjacent the frangible region away from the region of the proximal portion adjacent the frangible region after the proximal portion and the distal portion have uncoupled. 6. The nozzle assembly of claim 3, wherein a surface of the distal portion that is distal to the frangible region is planar and is at an angle relative to the longitudinal axis. 7. The nozzle assembly of claim 6, wherein the surface of the distal portion guides the region of the proximal portion adjacent the frangible region away from the region of the distal portion adjacent the frangible portion after the proximal portion and the distal portion have uncoupled. 8. The nozzle assembly of claim 3, wherein the region of the proximal portion adjacent the frangible region is adapted to rotate away from the region of the distal portion adjacent the frangible region about the longitudinal axis of the plunger. 9. A plunger for use in a needle-free injection device comprising: a plunger configured to move through an injectate chamber of the needle-free device toward an outlet orifice, the plunger including a proximal portion, a distal portion and a frangible region along which the proximal portion and distal portion are configured to uncouple upon injection;wherein the proximal portion is adapted to rotate relative to and away from the distal portion about a longitudinal axis of the plunger upon injection, the rotation being sufficient to prevent the proximal region from catching on the distal portion when the distal portion is withdrawn; andwherein the proximal portion remains in the injectate chamber upon retraction of the distal portion from the injectate chamber. 10. The plunger of claim 9, wherein the proximal portion is configured to lodge in a proximal end of the injectate chamber, thereby preventing intake of an injectate into the injectate chamber. 11. The plunger of claim 9, wherein the frangible region is configured to yield in response to a force applied along a longitudinal axis of the plunger. 12. The plunger of claim 11, wherein a surface of the proximal portion that is proximal to the frangible region is planar and is at an angle relative to the longitudinal axis. 13. The plunger of claim 12, wherein the surface of the proximal portion guides the region of the distal portion adjacent the frangible region away from the region of the proximal portion adjacent the frangible region after the proximal portion and the distal portion have uncoupled. 14. The plunger of claim 11, wherein a surface of the distal portion that is distal to the frangible region is planar and is at an angle relative to the longitudinal axis. 15. The plunger of claim 14, wherein the surface of the distal portion guides the region of the proximal portion adjacent the frangible region away from the region of the distal portion adjacent the frangible portion after the proximal portion and the distal portion have uncoupled. 16. The plunger of claim 11, wherein the region of the proximal portion adjacent the frangible region is adapted to rotate away from the region of the distal portion adjacent the frangible region about the longitudinal axis of the plunger. 17. A nozzle assembly for an injection device comprising: a nozzle body including an injectate chamber and an outlet orifice; anda plunger configured to move through the injectate chamber toward the outlet orifice, the plunger including a proximal portion, a distal portion, a frangible region along which the proximal portion and distal portion are configured to uncouple upon injection, a first surface proximal to the frangible region that is at an angle relative to a longitudinal axis of the injection device, and a second surface distal to the frangible region that is at an angle relative to the longitudinal axis of the injection device;wherein the first surface guides the proximal portion to rotate about a longitudinal axis of the plunger relative to and away from the distal portion during injection, the rotation being sufficient to prevent the proximal region from catching on the distal portion when the distal portion is withdrawn;wherein the second surface guides a region of the proximal portion adjacent the frangible region away from a region of the proximal portion adjacent the frangible region during injection; andwherein the proximal portion remains in the injectate chamber upon retraction of the distal portion from the injectate chamber.