IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0702245
(2010-02-08)
|
등록번호 |
US-8622992
(2014-01-07)
|
발명자
/ 주소 |
- Baxter, Blaise
- Devlin, Thomas
- Devlin, Christian
|
출원인 / 주소 |
|
대리인 / 주소 |
Soody Tronson Law Group, P.C.
|
인용정보 |
피인용 횟수 :
2 인용 특허 :
11 |
초록
Devices, methods, and assemblies for perfusion therapy including cerebral perfusion therapy such as those for use in the treatment of acute ischemic stroke. The treatment includes delivery of blood to or about the vicinity of a thrombus site.
대표청구항
▼
1. An assembly for cerebral perfusion therapy, including: an outer catheter configured for cerebral perfusion therapy and including a single lumen first elongate member having a proximal portion with a proximal end, a distal portion with a distally tapered distal end and an open distal tip, the tape
1. An assembly for cerebral perfusion therapy, including: an outer catheter configured for cerebral perfusion therapy and including a single lumen first elongate member having a proximal portion with a proximal end, a distal portion with a distally tapered distal end and an open distal tip, the tapered distal end configured to facilitate navigating the outer catheter into the cerebral circulation and traversing clots within vessels within the brain, an inner lumen extending along at least the distal portion, a plurality of apertures disposed along the distal portion and extending from an outer surface of the first elongate member to the first elongate member inner lumen; the outer catheter being further configured for perfusion of fluids including any one or more of blood, therapeutic agents, diagnostic agents, lytic solutions, and the like; through or in the vicinity of an obstructing cerebral thrombus; andAn inner catheter configured for use in cerebral perfusion therapy and including a second elongate member having a proximal portion with a proximal end, a distal portion with a distal end and an open distal tip, a lumen extending along at least the distal portion, the inner catheter configured for slidable coaxial advancement within the inner lumen of the outer catheter and slidable disposal at any one or more locations, proximal, adjacent, or distal; to at least a portion of the apertures; the inner catheter further being configured for extending distally from the open distal tip of the outer catheter. 2. A device according to claim 1, wherein the inner catheter is configured for slidably, to at least partially obstruct, at least a portion of the apertures, when the inner catheter is disposed in the inner lumen of the outer catheter enabling the distal flow of fluids through the open distal tip of the outer catheter to a treatment site distal to the thrombus. 3. A device according to claim 2, wherein the inner catheter is further configured for delivery of either or both fluids including blood, therapeutic agents, diagnostic agents, lytic solutions and the like; and delivery of treatment devices including thrombectomy devices; to or in the vicinity of the obstructing thrombus. 4. A device according to claim 3, further including a guide catheter having an inner lumen configured to receive the outer catheter therein. 5. A system for cerebral perfusion therapy, including: A cerebral perfusion device including an outer catheter configured for cerebral perfusion therapy and including a single lumen first elongate member having a proximal portion with a proximal end, a distal portion with a distally tapered distal end and an open distal tip, the tapered distal end configured to facilitate navigating the outer catheter into the cerebral circulation and traversing clots within vessels within the brain, an inner lumen extending along at least the distal portion, a plurality of apertures disposed along the distal portion and extending from an outer surface of the first elongate member to the first elongate member inner lumen; the outer catheter being further configured for perfusion of fluids including any one or more of blood, therapeutic agents, diagnostic agents, lytic solutions, and the like; through or in the vicinity of an obstructing cerebral thrombus; andAn inner catheter configured for use in cerebral perfusion therapy and including a second elongate member having a proximal portion with a proximal end, a distal portion with a distal end and an open distal tip, a lumen extending along at least the distal portion, the inner catheter configured for slidable coaxial advancement within the inner lumen of the outer catheter and slidable disposal at any one or more locations, proximal, adjacent, or distal; to at least a portion of the apertures; the inner catheter further being configured for extending distally from the open distal tip of the outer catheter; andA perfusion pump fluidically connectable to the cerebral perfusion device and configured to actively supply blood to or to a vicinity of a thrombus site through the perfusion device. 6. A system according to claim 5, wherein the inner catheter is configured for slidably, to at least partially obstruct, at least a portion of the apertures, when the inner catheter is disposed in the inner lumen of the outer catheter enabling the distal flow of fluids through the open distal tip of the outer catheter to a treatment site distal to the thrombus. 7. A system according to claim 6, wherein the blood delivered to the patient through the cerebral perfusion device is hyper-oxygenated prior to delivery to the patient's cerebral vessels by way of an external ventilator. 8. A method for cerebral perfusion therapy of a patient, including: Providing a cerebral perfusion device including an outer catheter configured for cerebral perfusion therapy and including a single lumen first elongate member having a proximal portion with a proximal end, a distal portion with a distally tapered distal end and an open distal tip, the tapered distal end configured to facilitate navigating the outer catheter into the cerebral circulation and traversing clots within vessels within the brain, an inner lumen extending along at least the distal portion, a plurality of apertures disposed along the distal portion and extending from an outer surface of the first elongate member to the first elongate member inner lumen; the outer catheter being further configured for perfusion of fluids including any one or more of blood, therapeutic agents, diagnostic agents, lytic solutions, and the like; through or in the vicinity of an obstructing cerebral thrombus; andan inner catheter configured for use in cerebral perfusion therapy and including a second elongate member having a proximal portion with a proximal end, a distal portion with a distal end and an open distal tip, a lumen extending along at least the distal portion, the inner catheter configured for slidable coaxial advancement within the inner lumen of the outer catheter and slidable disposal at any one or more locations, proximal, adjacent, or distal; to at least a portion of the apertures; the inner catheter further being configured for extending distally from the open distal tip of the outer catheter;Providing a perfusion pump fluidically connectable to the cerebral perfusion device and configured to actively supply blood to a treatment site through the outer catheter or the inner catheter;Advancing intracorporeally the outer catheter and the inner catheter through a patient's artery to a treatment site distal to a distal edge of the thrombus site;Retracting the inner catheter proximally to expose at least a portion of the apertures which are distal to the distal edge of the thrombus site; andPumping blood from the perfusion pump through either the outer catheter or the inner catheter to the treatment site distal to the thrombus site, through any one or more of the open distal tip of the outer catheter, the open distal tip of the inner catheter, and any unobstructed apertures. 9. A method according to claim 8, wherein the inner catheter at least substantially obstructs the apertures which are within or proximal to the thrombus area prior to delivering fluids from the pump to the treatment site which is distal to the thrombus. 10. A method according to claim 8, wherein the blood delivered to the patient through the cerebral perfusion device is hyper-oxygenated prior to delivery to the patient's cerebral vessels by way of an external ventilator. 11. A method according to claim 8, further including advancing a revascularizing device including an endovascular thrombectomy device through the inner lumen of the inner catheter and revascularizing the thrombus site. 12. A method according to claim 11, wherein the revascularization step includes advancing an endovascular thrombectomy device through the inner catheter and performing a thrombectomy procedure. 13. A method according to claim 12, wherein the method is to directly treat ischemic stroke. 14. A method for cerebral perfusion therapy of a patient, including: Providing a perfusion device including An outer catheter including an elongate member having proximal and distal ends, proximal and distal portions, an inner lumen extending along at least the distal portion, a plurality of apertures disposed along the distal portion and extending from an outer surface of the elongate member to the inner lumen; andAn inner catheter including an elongate member having proximal and distal ends, proximal and distal portions, a lumen extending along at least the distal portion, the inner catheter configured for slidable disposal within the inner lumen of the outer catheter and further configured for slidable disposal adjacent at least a portion of the apertures and further configured to slidably at least partially obstruct at least a portion of the apertures; the inner catheter further configured to be disposed at least partially within the inner lumen of the perfusion catheter during an advancing step;Providing a perfusion pump fluidically connectable to the perfusion device and configured to actively supply blood to a treatment site through the outer catheter or the inner catheter;Advancing intracorporeally the outer catheter and the inner catheter through a patient's artery to a treatment site distal to a thrombus site;Retracting the inner catheter proximally to expose at least a portion of the apertures; andPumping blood from the perfusion pump through the outer catheter or the inner catheter to the treatment site distal to the thrombus site. 15. A method according to claim 8, wherein the inner catheter substantially obstructs the apertures of the outer catheter which are within or proximal to the thrombus. 16. A method according to claim 8, wherein the inner catheter substantially obstructs fluid flow from all the apertures. 17. A method according to claim 8, further including retracting the inner catheter proximally to expose at least a portion of the apertures of the outer catheter which are distal to the distal edge of the thrombus, the method further including perfusion of the fluid to the treatment site which is distal to the distal edge of the thrombus by way of any one or more of the unobstructed apertures, the open distal tip of the outer catheter, and the open distal tip of the inner catheter. 18. A method according to claim 8, the method further including retracting the inner catheter proximally to remove it from the inner lumen of the outer catheter, the method further including delivering fluids directly through the outer catheter and perfusing fluids including blood into cerebral vessels distal to the thrombus. 19. A method according to claim 8, the method further including perfusion of one or more fluids directly through the outer catheter.
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