IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0984482
(2011-01-04)
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등록번호 |
US-8627861
(2014-01-14)
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발명자
/ 주소 |
- Py, Daniel
- Chan, Julian V.
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출원인 / 주소 |
- Medical Instill Technologies, Inc.
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대리인 / 주소 |
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인용정보 |
피인용 횟수 :
0 인용 특허 :
277 |
초록
▼
A dispenser for holding multiple doses of fluids or other substances, and for dispensing the substances, has a vial, a flexible bladder received within the vial, and a variable volume storage chamber formed between the bladder and vial. A filling valve is coupled in fluid communication with the stor
A dispenser for holding multiple doses of fluids or other substances, and for dispensing the substances, has a vial, a flexible bladder received within the vial, and a variable volume storage chamber formed between the bladder and vial. A filling valve is coupled in fluid communication with the storage chamber and defines (1) a normally closed, fluid-tight position hermetically sealing the storage chamber from the ambient atmosphere, and (2) an open position allowing the passage of fluid through the valve both to evacuate the storage chamber and to introduce fluid through the valve to fill the storage chamber. A pump is coupled in fluid communication with the storage chamber for pumping fluids out of the storage chamber. A dispensing valve is coupled in fluid communication with the pump and defines (1) a normally closed, fluid-tight position preventing the passage of fluid out of the dispenser, and (2) an open position for dispensing pumped fluid therethrough. The sealed, empty dispenser is sterilized, such as by applying gamma radiation thereto. Then, the sterilized, sealed, empty dispenser is filled with fluid by engaging the filling valve with an evacuating/dispensing member to evacuate the storage chamber, and by introducing fluid from the filling member through the open filling valve and into the storage chamber. The filling member is withdrawn from the valve, and a spring moves the valve to a closed position to hermetically seal the fluid within the dispenser.
대표청구항
▼
1. A method comprising: sterilizing a sealed empty device having a collapsible variable-volume storage chamber;sealingly engaging a filling member with the device, and, in turn, forming an opening in fluid communication with the sealed variable-volume storage chamber;evacuating the device via the fi
1. A method comprising: sterilizing a sealed empty device having a collapsible variable-volume storage chamber;sealingly engaging a filling member with the device, and, in turn, forming an opening in fluid communication with the sealed variable-volume storage chamber;evacuating the device via the filling member, thereby collapsing the variable-volume storage chamber;introducing fluid or other substance through the filling member and said opening and into the collapsed variable-volume storage chamber; andpreventing said fluid or other substance from exiting the device during said introducing step. 2. A method as defined in claim 1, further comprising: withdrawing the filling member from the device after said introducing step; andresealing the opening in the variable-volume storage chamber. 3. A method as defined in claim 1, wherein said device includes a filling valve and a dispensing valve, and wherein said preventing step includes preventing said fluid or other substance from exiting the device through the dispensing valve during said introducing step. 4. A method as defined in claim 3, wherein said preventing step includes preventing fluid communication between the filling valve and the dispensing valve. 5. A method as defined in claim 1, wherein said device includes a filling valve coupled in fluid communication with the variable-volume storage chamber and defining (1) a normally closed, fluid tight position hermetically sealing the storage chamber, and (2) an open position permitting flow of fluid or other substance therethrough, and wherein the engaging step comprises moving said filling valve with said filling member from the normally closed position into the open position, and, in turn, forming said opening in fluid communication with the sealed variable-volume storage chamber. 6. A method as defined in claim 2, wherein said device includes a filling valve coupled in fluid communication with the variable-volume storage chamber and defining (1) a normally closed, fluid tight position hermetically sealing the storage chamber, and (2) an open position permitting flow of fluid or other substance therethrough, and wherein the engaging step comprises moving said filling valve with said filling member from the normally closed position into the open position, and, in turn, forming said opening in fluid communication the sealed variable-volume storage chamber. 7. A method as defined in claim 6, wherein said filling valve defines an substantially dome-shaped spring adapted to normally bias the valve from said opening position into said closed position, and wherein said resealing step comprises disengaging said filling member from said filling valve, and, in turn, returning said filling valve form the open position to the closed position. 8. A method as defined in claim 1, further comprising the step of re-sterilizing the sealed evacuated device after the evacuating step and prior to the introducing step. 9. A method as defined in claim 8, wherein the sterilizing and/or re-sterilizing steps comprise applying gamma, e-beam or other radiation to the device. 10. A method as defined in claim 2, further comprising the step of dispensing a metered amount of said fluid or other substance from said device. 11. A method as defined in claim 1, further comprising directing a substantially laminar flow of sterilized air or other gas over the filling member and device during said introducing step.
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