Engineered polypeptide agents for targeted broad spectrum influenza neutralization
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IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-038/16
C07K-014/00
C07K-016/46
C12Q-001/70
A61P-031/16
출원번호
US-0015455
(2011-01-27)
등록번호
US-8637456
(2014-01-28)
발명자
/ 주소
Sasisekharan, Ram
Viswanathan, Karthik
Soundararajan, Venkataramanan
Raguram, S.
Sasisekharan, Viswanathan
Subramanian, Vidya
출원인 / 주소
Massachusetts Institute of Technology
대리인 / 주소
Choate, Hall & Stewart LLP
인용정보
피인용 횟수 :
4인용 특허 :
30
초록▼
The present invention provides novel agents for broad spectrum influenza neutralization. The present invention provides agents for inhibiting influenza infection by bind to the influenza virus and/or hemagglutinin (HA) polypeptides and/or HA receptors, and reagents and methods relating thereto. The
The present invention provides novel agents for broad spectrum influenza neutralization. The present invention provides agents for inhibiting influenza infection by bind to the influenza virus and/or hemagglutinin (HA) polypeptides and/or HA receptors, and reagents and methods relating thereto. The present invention provides a system for analyzing interactions between infolds and the interaction partners that bind to them.
대표청구항▼
1. An infold agent that binds an hemagglutinin (HA) polypeptide, which infold agent comprises an infold selected from the group consisting of Infold-1, Infold-2, Infold-3, Infold-4, Infold-5, Infold-6, Infold-7, Infold-8, Infold-9, Infold-10, Infold-11, Infold-12, Infold-13, Infold-14, Infold-15, In
1. An infold agent that binds an hemagglutinin (HA) polypeptide, which infold agent comprises an infold selected from the group consisting of Infold-1, Infold-2, Infold-3, Infold-4, Infold-5, Infold-6, Infold-7, Infold-8, Infold-9, Infold-10, Infold-11, Infold-12, Infold-13, Infold-14, Infold-15, Infold-16, Infold-17, Infold-18, Infold-19, Infold-20, Infold-21, Infold-22, Infold-23, Infold-24, Infold-25, Infold-26, Infold-27, Infold-28, Infold-29, Infold-30, Infold-31, Infold-32, Infold-33, Infold-34, Infold-35, Infold-36, Infold-37, Infold-38, Infold-39, and Infold-40. 2. The infold agent of claim 1, wherein the infold agent comprises Infold-3. 3. The infold agent of claim 1, wherein the infold agent comprises Infold-28. 4. A pharmaceutical composition comprising: an infold agent of claim 1 and a pharmaceutically acceptable carrier. 5. An infold agent that binds an HA polypeptide, which infold agent comprises Infold-22. 6. A pharmaceutical composition comprising: the infold agent of claim 5 and a pharmaceutically acceptable carrier. 7. A method of treating influenza A virus subtype H1N1 or H3N2 in a subject comprising administering to the subject the pharmaceutical composition of claim 4, wherein the subject has been exposed to an infected source selected from the group consisting of avian, human, swine and combinations thereof. 8. The method of claim 7, comprising administering the pharmaceutical composition in combination with one or more other pharmaceutical agents.
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