A system for at least partially filling and marking a cavity at a site within a patient's body includes a marker delivery device having a chamber configured to contain a marking substance and having a mechanism configured to expel the marking substance. A quantity of the marking substance is contain
A system for at least partially filling and marking a cavity at a site within a patient's body includes a marker delivery device having a chamber configured to contain a marking substance and having a mechanism configured to expel the marking substance. A quantity of the marking substance is contained within the chamber of the marker delivery device. The marking substance is configured to at least partially fill the cavity and form therein a porous bioabsorbable body. A delivery tube is coupled in fluid communication with the chamber of the marker delivery device. The delivery tube has a distal end with a discharge port through which the marking substance is expelled. A marker is configured to be delivered to the cavity from the distal end of the delivery tube and is configured to remain with the porous bioabsorbable body within the cavity upon the formation thereof.
대표청구항▼
1. A system for at least partially filling and marking a cavity at a site within a patient's breast from which tissue has been removed, comprising: a syringe having an elongated body, an inner bore, and a plunger slidably disposed within the inner bore;a delivery tube having a distal end with a disc
1. A system for at least partially filling and marking a cavity at a site within a patient's breast from which tissue has been removed, comprising: a syringe having an elongated body, an inner bore, and a plunger slidably disposed within the inner bore;a delivery tube having a distal end with a discharge port and a delivery tube bore in fluid communication with the inner bore of the syringe and the discharge port;a quantity of marker forming fluid within the inner bore of the syringe configured to at least partially fill the cavity at the biopsy site and form therein a porous bioabsorbable body; anda radiopaque marker attached to an external surface of a portion of the delivery tube; the radiopaque marker configured to be delivered to the cavity from the distal end of the delivery tube comprising radiopaque metal and configured to remain within the porous bioabsorbable body within the cavity upon the formation thereof. 2. The system of claim 1, wherein the radiopaque marker is threadably connected to the distal end of the delivery tube. 3. The system of claim 1, wherein the radiopaque marker is coupled to an external surface of the distal end of the delivery tube. 4. The system of claim 1, wherein the radiopaque marker is a distal tip of the delivery tube. 5. The system of claim 1, wherein the marker forming fluid comprises a non-aqueous solvent which is relatively soluble in a body fluid or other water based fluid and a bioabsorbable polymeric solute, and which forms in the cavity the porous bioabsorbable body. 6. The system of claim 5, wherein the bioabsorbable polymeric solute includes a copolymer having about 65% (by wt.) polylactic acid and about 35% (by wt.) polyglycolic acid. 7. The system of claim 1, wherein the quantity of marker forming fluid in the inner bore of the syringe is about 0.2 ml to about 1.2 ml. 8. The system of claim 1, wherein the radiopaque marker is formed of one or more materials selected from the group consisting of stainless steel, platinum, gold, iridium, tantalum, tungsten, silver, rhodium, nickel, bismuth, other radiopaque metals, alloys of radiopaque metals and mixtures of radiopaque metals, and combinations thereof. 9. The system of claim 1, wherein the marker forming fluid includes at least one agent selected from the group consisting of therapeutic, diagnostic agents, and a hemostatic agent. 10. The system of claim 1, wherein the marker forming fluid includes a radioactive element. 11. The system of claim 10, wherein the radioactive element is a brachytherapy seed. 12. A system for at least partially filling and marking a cavity at a site within a patient's breast from which tissue has been removed, comprising: a syringe having an elongated body, an inner bore, and a plunger slidably disposed within the inner bore;a delivery tube having a distal end with a discharge port and a delivery tube bore in fluid communication with the inner bore of the syringe and the discharge port, the syringe and the delivery tube forming a delivery device;a quantity of marker forming fluid within the inner bore of the syringe configured to at least partially fill the cavity at the biopsy site and form therein a porous bioabsorbable body; anda marker element attached to an external surface of the delivery device, the marker element configured to be delivered to the cavity from the delivery tube and configured to accompany the porous bioabsorbable body within the cavity upon the formation of the porous bioabsorbable body. 13. The system of claim 12, wherein the radiopaque marker is coupled to an external surface of the distal end of the delivery tube. 14. The system of claim 12, wherein the marker forming fluid contains about 1 to about 50% by weight water insoluble, bioabsorbable polymeric solute. 15. The system of claim 12, wherein the marker forming fluid contains about 10 to about 90% by weight water insoluble, bioabsorbable polymeric solute. 16. A system for at least partially filling and marking a cavity at a site within a patient's body from which tissue has been removed, comprising: a marker delivery device having a chamber configured to contain a marking substance, the marker delivery device having a mechanism configured to expel the marking substance;a quantity of the marking substance contained within the chamber of the marker delivery device, the marking substance being configured to at least partially fill the cavity at the biopsy site and form therein a porous bioabsorbable body;a delivery tube coupled in fluid communication with the chamber of the marker delivery device, the delivery tube having a distal end with a discharge port through which the marking substance is expelled; anda releasable marker configured to be released from the delivery tube by an action separate from that of the marking substance being expelled, the releasable marker being disposed within the cavity with the porous bioabsorbable body formed in the cavity. 17. The system of claim 16, wherein the releasable marker forms an extension of the delivery tube to define the discharge port. 18. The system of claim 16, wherein the releasable marker comprises radiopaque material. 19. The system of claim 16, wherein the marking substance in the chamber of the marker delivery device is a marker forming fluid. 20. The system of claim 19, wherein the marker forming fluid in the chamber of the marker delivery device comprises a non-aqueous solvent which is relatively soluble in a body fluid or other water based fluid, a bioabsorbable polymeric solute comprising a copolymer of polylactic acid and polyglycolic acid in a weight ratio of 90:10 to 60:40 in the non-aqueous solvent which is relatively insoluble in body fluid or other water based fluid and which forms in the cavity the porous bioabsorbable body.
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