Transdermal porator and patch system and method for using same
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61M-035/00
A61F-013/02
A61N-001/30
출원번호
US-0272592
(2011-10-13)
등록번호
US-8641689
(2014-02-04)
발명자
/ 주소
Messier, Bernadette
Novakovic, Zoran
O'Leary, Jeremiah Peter
Spiehl, Regina
Bowerman, Wendy E.
Braun, Stephen Wilson
Eppstein, Jonathan
Farquhar, David
Fisher, Mark James
Kascak, Uros
Henkel, Erin Koch
Lantz, Loren J.
McRae, Stuart
출원인 / 주소
Nitto Denko Corporation
대리인 / 주소
King & Spalding
인용정보
피인용 횟수 :
0인용 특허 :
115
초록▼
A transdermal permeant delivery system for delivery of at least one permeant composition into a tissue membrane of a subject including a disposable substrate having at least a portion of a bottom surface of a first release liner connected to an upper surface of the substrate and a patch having a bac
A transdermal permeant delivery system for delivery of at least one permeant composition into a tissue membrane of a subject including a disposable substrate having at least a portion of a bottom surface of a first release liner connected to an upper surface of the substrate and a patch having a backing layer and a reservoir that is selectively removable from the top surface of the first release liner. In a connected position, a first portion of the backing layer of the patch is releaseably mounted to a top surface of the first release liner in spaced registration with a poration area of the substrate.
대표청구항▼
1. A transdermal permeant delivery system comprising: i) a disposable substrate defining a poration area andhaving an upper substrate surface, a lower substrate surface, a conduit that extends between the upper substrate surface and the lower substrate surface, andat least one channel disposed on th
1. A transdermal permeant delivery system comprising: i) a disposable substrate defining a poration area andhaving an upper substrate surface, a lower substrate surface, a conduit that extends between the upper substrate surface and the lower substrate surface, andat least one channel disposed on the upper substrate surface and in fluid communication with the conduit so that a vacuum, generated by a vacuum source to be provided to the system, is delivered to the poration area via the conduit and the at least one channel;ii) a first release liner having a top surface and an opposed bottom surface, wherein at least a portion of the bottom surface of the first release liner is connected to the upper substrate surface; andiii) a patch that is selectively removable from the top surface of the first release liner, the patch comprising: a) a backing layer having an upper surface and an opposed lower surface, andb) a reservoir mounted thereon a portion of the lower surface of the backing layer and configured for releaseably containing at least one permeant;wherein, in a connected position, at least a portion of the backing layer of the patch is releaseably mounted thereto the top surface of the first release liner in spaced registration with the poration area of the substrate. 2. The system of claim 1, wherein the patch further comprises a skin adhesive layer disposed thereon at least a portion of the lower surface of the backing layer of the patch. 3. The system of claim 2, further comprising a second release liner that is releaseably mountable to a portion of the skin adhesive layer. 4. The system of claim 1, wherein a first portion of the backing layer is releaseably mounted thereto the top surface of the first release liner in spaced registration with the poration area of the substrate, and wherein,in the connected position, a second portion of the backing layer is folded back into a folded position, in which the lower surface of the second portion of the backing layer faces outwardly away from the upper substrate surface of the substrate. 5. The system of claim 4, wherein the force required to remove the second release liner from the skin adhesive layer is less than the force required to remove the first portion of the backing layer from the top surface of the first release liner. 6. The system of claim 4, wherein, in a connected position, the first portion of the backing layer is positioned in folded registration with the poration area of the substrate. 7. The system of claim 1, further comprising a means for forming at least one micropore in the tissue membrane, wherein said means is mounted on the substrate, and wherein at least a portion of the means is positioned within the poration area. 8. The system of claim 7, wherein the means for forming at least one micropore is selected from the group consisting of: at least one filament capable of conductively delivering thermal energy via direct contact to the tissue membrane to cause the ablation of some portion of that membrane deep enough to form the micropore,at least one probe element capable of delivering electrical energy via direct contact to a tissue membrane to cause ablation of some portion of said membrane deep enough to form the micropore,an electro-mechanical applicator,a microlancet,an array of microneedles or lancets,a sonic energy ablator, a laser ablation system, and a high-pressure fluid jet puncturer. 9. The system of claim 8, wherein the means for forming at least one micropore is at least one filament. 10. The system of claim 1, wherein the at least one permeant is a drug or biologically active ingredient. 11. The system of claim 1, further comprising an applicator comprising: a body defining an interior cavity;a controller board comprising driving electronics and a power source, wherein the controller board is positioned within the interior cavity; andan interface for releasably receiving the substrate. 12. The system of claim 9, wherein the means for forming at least one micropore is a filament array. 13. The system of claim 2, wherein the filament array is mounted to a portion of the upper substrate surface, and wherein the substrate further comprises a backing that is configured for mounting to and overlying a top surface of the filament array such that a portion of the filament array in the poration area is exposed. 14. The system of claim 3, wherein the filament array is enclosed in the substrate, and wherein the portion of the filament array in the poration area is exposed.
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