IPC분류정보
국가/구분 |
United States(US) Patent
등록
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국제특허분류(IPC7판) |
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출원번호 |
US-0878163
(2007-07-20)
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등록번호 |
US-8642016
(2014-02-04)
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발명자
/ 주소 |
- Chau, Tommy L.
- Pinney, John M.
- Henningfield, Jack E.
- Cone, Edward J.
- Shiffman, Saul M.
- Gitchell, Joseph G.
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 |
피인용 횟수 :
0 인용 특허 :
147 |
초록
▼
A method is provided of making a medicinal delivery system which satiates a craving in an individual when the medicinal delivery system is administered orally to the individual. A coating composition is applied on a saliva-soluble powder to establish a coated powder, the coating composition featurin
A method is provided of making a medicinal delivery system which satiates a craving in an individual when the medicinal delivery system is administered orally to the individual. A coating composition is applied on a saliva-soluble powder to establish a coated powder, the coating composition featuring an at least partially solubilized craving satiation medicinal compound. The coated powder is combined with an edible carrier base to establish a medicinal delivery system that rapidly releases medicine and buffer preferably followed by slower, sustained release.
대표청구항
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1. A method of making a medicinal delivery system for oral delivery of a nicotine compound which satiates nicotine craving for an individual in need of nicotine-craving relief, comprising: providing a paste comprising a solvent-treated nicotine compound that has been at least partially dissolved in
1. A method of making a medicinal delivery system for oral delivery of a nicotine compound which satiates nicotine craving for an individual in need of nicotine-craving relief, comprising: providing a paste comprising a solvent-treated nicotine compound that has been at least partially dissolved in a solvent of a bulk sweetener solution to make the nicotine compound more readily dissolvable during ingestion or mastication to promote a high initial nicotine release rate;coating a saliva-soluble bulk sweetener powder with the paste to establish a coated powder premix; andsubsequent to establishing the coated powder premix, distributing the coated powder premix in an edible carrier base selected from the group consisting of a chewing gum base and a lozenge base and combining the edible carrier base and the coated powder premix with a buffer to establish a medicinal delivery system,wherein the nicotine compound comprises at least one member selected from the group consisting of nicotine, nor-nicotine, lobeline, free base nicotine, and pharmacologically acceptable salts of nicotine. 2. The method of claim 1, wherein the bulk sweetener solution comprises a sorbitol solution. 3. The method of claim 1, wherein the saliva-soluble bulk sweetener powder comprises a bulk sweetener selected from the group consisting of sorbitol, xylitol, mannitol, isomalt, maltitol, and lactitol. 4. The method of claim 1, wherein the saliva-soluble bulk sweetener powder comprises sorbitol powder. 5. The method of claim 1, wherein the solvent of the bulk sweetener solution has been removed from the paste prior to said coating of the saliva-soluble bulk sweetener powder. 6. The method of claim 1, wherein the solvent of the bulk sweetener solution is retained in the paste for said coating of the saliva-soluble bulk sweetener powder. 7. The method of claim 1, wherein the carrier base comprises chewing gum. 8. The method of claim 1, wherein the carrier base comprises a lozenge. 9. The method of claim 1, wherein the medicinal delivery system provides for about 45% or more release of the nicotine compound within 5 minutes of the onset of ingestion or mastication. 10. The method of claim 1, wherein the medicinal delivery system provides for about 50% or more release of the nicotine compound within 5 minutes of the onset of ingestion or mastication. 11. A method of making a medicinal delivery system for oral delivery of a nicotine compound which satiates nicotine craving for an individual in need of nicotine-craving relief, comprising: at least partially dissolving a nicotine compound in a solvent of a bulk sweetener solution to form a paste;coating a saliva-soluble bulk sweetener powder with the paste to establish a coated powder premix; andsubsequent to establishing the coated powder premix, distributing the coated powder premix in an edible carrier base selected from the group consisting of a chewing gum base and a lozenge base and combining the edible carrier base and the coated powder premix with a buffer to establish a medicinal delivery system,wherein the nicotine compound comprises at least one member selected from the group consisting of nicotine, nor-nicotine, lobeline, free base nicotine, and pharmacologically acceptable salts of nicotine. 12. The method of claim 11, wherein the bulk sweetener solution comprises a sorbitol solution. 13. The method of claim 11, wherein the saliva-soluble bulk sweetener powder comprises a bulk sweetener selected from the group consisting of sorbitol, xylitol, mannitol, isomalt, maltitol, and lactitol. 14. The method of claim 11, wherein the saliva-soluble bulk sweetener powder comprises sorbitol powder. 15. The method of claim 11, further comprising removing the solvent of the bulk sweetener solution from the paste prior to said coating of the saliva-soluble bulk sweetener powder. 16. The method of claim 11, further comprising retaining the solvent of the bulk sweetener solution in the paste for said coating of the saliva-soluble bulk sweetener powder. 17. The method of claim 11, wherein the carrier base comprises chewing gum. 18. The method of claim 11, wherein the carrier base comprises a lozenge. 19. The method of claim 11, wherein the medicinal delivery system provides for about 45% or more release of the nicotine compound within 5 minutes of the onset of ingestion or mastication. 20. The method of claim 11, wherein the medicinal delivery system provides for about 50% or more release of the nicotine compound within 5 minutes of the onset of ingestion or mastication.
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