Dry powder inhalers with rotating piercing mechanisms and related devices and methods
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61M-016/00
A61M-015/00
출원번호
US-0054809
(2009-09-25)
등록번호
US-8646446
(2014-02-11)
국제출원번호
PCT/US2009/005338
(2009-09-25)
§371/§102 date
20110415
(20110415)
국제공개번호
WO2010/039202
(2010-04-08)
발명자
/ 주소
Lewis, Scott Alexander
Gow, Andrew Murray
Tuckwell, Jonathan David
Beard, Greg
Harris, David
출원인 / 주소
Oriel Therapeutics, Inc.
대리인 / 주소
Myers Bigel Sibley & Sajovec, P.A.
인용정보
피인용 횟수 :
2인용 특허 :
58
초록▼
Dry powder inhalers with rotatable piercing mechanisms facilitate the use of dose container assemblies having dose containers arranged in concentric rows. A piercing mechanism is operably associated with the dose container assembly and is configured to pierce sealants that seal a dose container. The
Dry powder inhalers with rotatable piercing mechanisms facilitate the use of dose container assemblies having dose containers arranged in concentric rows. A piercing mechanism is operably associated with the dose container assembly and is configured to pierce sealants that seal a dose container. The piercing mechanism is rotatable such that it can serially alternate between the two rows of dose containers. The piercing mechanism includes a rotatable drum, an elongate piercing member, and a biasing member operably associated with the piercing member. The rotatable drum has an open end, an opposite closed end, and a cylindrical wall that extends from the closed end and terminates at the open end. The closed end includes an aperture formed therein in a location adjacent to the wall. The elongate piercing member is extended and retracted through the aperture to pierce the sealants of a dose container.
대표청구항▼
1. A dry powder inhaler, comprising: a housing;a dose container disk rotatably secured within the housing, wherein the dose container disk comprises opposing upper and lower primary surfaces, a first row of circumferentially spaced apart through apertures associated with dose containers at a first r
1. A dry powder inhaler, comprising: a housing;a dose container disk rotatably secured within the housing, wherein the dose container disk comprises opposing upper and lower primary surfaces, a first row of circumferentially spaced apart through apertures associated with dose containers at a first radius and a second row of circumferentially spaced apart apertures associated with dose containers at a second radius;a first flexible sealant residing over the apertures in the upper surface, and a second flexible sealant residing over the apertures in the lower surface, and wherein the dose containers have dry powder therein; anda piercing mechanism configured to serially alternate between rows to pierce the sealants of a respective dose container in the first row, then pierce the sealants of a respective dose container in the second row, wherein the piercing mechanism comprises: a rotatable drum; andan elongate piercing member operably associated with the rotatable drum and capable of reciprocal movement between piercing and non-piercing positions. 2. The dry powder inhaler of claim 1, wherein the rotatable drum comprises an open end, an opposite closed end, and a cylindrical wall extending from the closed end and terminating at the open end, wherein the closed end includes an aperture formed therein and wherein the elongate piercing member comprises a distal piercing portion and a proximal head portion, wherein the distal piercing portion extends through the drum aperture and through the first and second sealants when the piercing member is in a piercing position, and wherein the distal piercing portion is retracted above a lower surface of the drum aperture when in a retracted position. 3. The dry powder inhaler of claim 1, wherein the piercing mechanism comprises a biasing member configured to urge the piercing member toward a retracted position. 4. The dry powder inhaler of claim 2, wherein the drum comprises gear teeth that extend circumferentially around the cylindrical wall, and further comprising a ring gear rotatably secured within the housing, wherein the drum gear teeth cooperate with the ring gear such that rotation of the ring gear by a predetermined amount causes the drum to rotate such that the piercing member moves from a position overlying a dose container in one row to a position overlying a dose container in the other row. 5. The dry powder inhaler of claim 2, wherein the drum comprises gear teeth that extend circumferentially around the cylindrical wall, and further comprising a ring gear rotatably secured within the housing, wherein the drum gear teeth cooperate with the ring gear such that rotation of the ring gear by a predetermined amount causes the drum to rotate about one-hundred eighty degrees (180°). 6. The dry powder inhaler of claim 4, wherein the ring gear comprises sets of teeth circumferentially spaced-apart. 7. The dry powder inhaler of claim 4, wherein the dose container assembly comprises gear teeth on an outer perimeter thereof, wherein the drum cylindrical wall comprises a pair of one or more teeth extending outwardly from the wall in diametric opposition that are configured to engage the dose container assembly gear teeth, and wherein rotation of the drum causes rotation of the dose container assembly. 8. The dry powder inhaler of claim 4, further comprising an actuator that is movable between first and second positions, wherein movement of the actuator from the first position to the second position causes the piercing member to pierce the sealants over and under a dose container and then move to a partially retracted position, and wherein movement of the actuator from the second position to the first position causes the piercing member to retract and the ring gear to move the predetermined amount such that the piercing member rotates from a position overlying a dose container in one row to another position overlying a dose container in the other row. 9. The dry powder inhaler of claim 8, wherein rotation of the piercing member causes the dose container assembly to rotate relative to the piercing mechanism. 10. The dry powder inhaler of claim 4, further comprising an actuator that is movable between first and second positions, wherein movement of the actuator from the first position to the second position causes the ring gear to move the predetermined amount such that the piercing member rotates from a position overlying a dose container in one row to another position overlying a dose container in the other row, to pierce the sealants over and under a dose container, and then move to a partially retracted position, and wherein movement of the actuator from the second position to the first position causes the piercing member to fully retract. 11. The dry powder inhaler of claim 10, wherein rotation of the piercing member causes the dose container assembly to rotate relative to the piercing mechanism. 12. The dry powder inhaler of claim 4, further comprising an actuator that is movable between first and second positions, wherein movement of the actuator from the first position to the second position causes the piercing member to pierce the sealants over and under a dose container, and wherein movement of the actuator from the second position to the first position causes the piercing member to retract and the ring gear to move the predetermined amount such that the piercing member rotates from a position overlying a dose container in one row to another position overlying a dose container in the other row. 13. The dry powder inhaler of claim 4, further comprising an actuator that is movable between first and second positions, wherein movement of the actuator from the first position to the second position causes the ring gear to move the predetermined amount such that the piercing member rotates from a position overlying a dose container in one row to another position overlying a dose container in the other row, and wherein movement of the actuator from the second position to the first position causes the piercing member to fully retract. 14. The dry powder inhaler of claim 8, wherein the ring gear comprises an inner perimeter having a plurality of spaced-apart steps, and wherein the actuator comprises a pawl that engages one of the plurality of spaced-apart steps to cause rotation of the ring gear when the actuator is moved from the second position to the first position. 15. The dry powder inhaler of claim 8, wherein the actuator comprises a first portion that engages the head portion of the piercing member and that causes the piercing member to move to the piercing position, and an adjacent second portion causes the piercing member to move to the partially retracted position. 16. The dry powder inhaler of claim 10, wherein the ring gear comprises an inner perimeter having a plurality of spaced-apart steps, and wherein the actuator comprises a pawl that engages one of the plurality of spaced-apart steps to cause rotation of the ring gear when the actuator is moved from the first position to the second position. 17. The dry powder inhaler of claim 10, wherein the actuator comprises a first portion that engages the head portion of the piercing member and that causes the piercing member to move to the piercing position, and an adjacent second portion causes the piercing member to move to the partially retracted position. 18. The dry powder inhaler of claim 1, wherein the first row of dose containers have centerlines that are circumferentially spaced apart from centerlines of the second row of dose containers. 19. The dry powder inhaler of claim 1, wherein the piercing member comprises a corkscrew piercer configured to pierce the sealants with a straight vertical non-rotational movement. 20. The dry powder inhaler of claim 1, wherein the piercing member comprises a fluted piercer configured to pierce the sealants. 21. The dry powder inhaler of claim 20, wherein the fluted piercer comprises three or four lobes. 22. The dry powder inhaler of claim 1, wherein each dose container comprises a dry powder having a pharmaceutically active agent, and wherein the agent comprises one or more of the following bronchodilators: albuterol, salmeterol, ephedrine, adrenaline, fenoterol, formoterol, isoprenaline, metaproterenol, phenylephrine, phenylpropanolamine, pirbuterol, reproterol, rimiterol, terbutaline, isoetharine, tulobuterol, or (−)-4-amino-3,5-dichloro-.alpha.-[[[6-[2-(2-pyridinyl)ethoxy]hexyl]methyl]benzenemethanol;wherein the bronchodilator may be used in the form of salts, esters or solvates to thereby optimize the activity and/or stability of the medicament. 23. The dry powder inhaler of claim 2, wherein the drum comprises gear teeth that extend circumferentially around the cylindrical wall, and further comprising: a ring gear rotatably secured within the housing and comprising sets of teeth circumferentially spaced-apart; andan actuator that is movable between first and second positions, wherein movement of the actuator from the first position to the second position causes rotation of the ring gear by a predetermined amount,wherein, during a first stage of the rotation, a first set of ring gear teeth cooperates with the drum gear teeth and rotates the drum such that the piercing member overlies a dose container,wherein, during a second stage of the rotation, the piercing member is moved to the piercing position,wherein, during a third stage of the rotation, the piercing member is moved to the retracted position, andwherein, during a fourth stage of the rotation, a second set of ring gear teeth cooperates with the drum gear teeth and rotates the drum such that the piercing member does not overlie a dose container. 24. The dry powder inhaler of claim 23, wherein the dose container assembly comprises gear teeth on an outer perimeter thereof, wherein the drum cylindrical wall comprises a pair of one or more teeth extending outwardly from the wall in diametric opposition that are configured to engage the dose container assembly gear teeth, and wherein rotation of the drum causes rotation of the dose container assembly. 25. The dry powder inhaler of claim 23, wherein the actuator comprises a ramp;wherein the piercing mechanism comprises at least one arm extending outwardly therefrom;wherein, during the second stage of the rotation, the at least one arm is contacted by the ramp to urge the piercing member to the piercing position; andwherein, during the third stage of the rotation, the at least one arm disengages from the ramp and the piercing member is urged to the retracted position by a biasing member. 26. The dry powder inhaler of claim 25, wherein the ramp comprises spaced-apart first and second inclined portions, wherein the at least one arm comprises a pair of arms extending outwardly from the piercing member in opposing relationship, and wherein, during the second stage of the rotation, each arm is contacted by a respective inclined portion to urge the piercing member to the piercing position. 27. The dry powder inhaler of claim 23, wherein the drum is rotated by ninety degrees (90°) during the first stage, and wherein the drum is rotated by ninety degrees (90°) during the fourth stage. 28. The dry powder inhaler of claim 2, wherein the drum comprises gear teeth that extend circumferentially around the cylindrical wall, and further comprising: a ring gear rotatably secured within the housing and comprising sets of teeth circumferentially spaced-apart; andan actuator that is movable between first and second positions, wherein movement of the actuator from the first position to the second position causes rotation of the ring gear by a predetermined amount,wherein, during a first stage of the rotation, a first set of ring gear teeth cooperates with the drum gear teeth and rotates the drum such that the piercing member overlies a dose container,wherein, during a second stage of the rotation, the piercing member is moved to the piercing position, andwherein, during a third stage of the rotation, the piercing member is moved to a partially retracted position. 29. The dry powder inhaler of claim 28, wherein the actuator comprises a pair of ramps positioned in adjacent, spaced-apart relationship;wherein the piercing mechanism comprises a pair of arms extending outwardly therefrom in opposing relationship;wherein, during the second stage of the rotation, each arm is contacted by a respective ramp to urge the piercing member to the piercing position; andwherein, during the third stage of the rotation, each arm disengages from a respective ramp and the piercing member is urged to a partially retracted position by a biasing member. 30. The dry powder inhaler of claim 29, wherein each ramp comprises a first leg attached to an actuator surface and a second leg having a free end adjacent to the actuator surface, wherein, during the second stage of the rotation, an arm is contacted by a respective second leg to urge the piercing member to the piercing position, and wherein the second leg is configured to deflect such that a respective arm can pass between the free end and the actuator surface when the actuator is moved from the second position to the first position. 31. A method of operating an inhaler, comprising: providing a dose container disk having opposing upper and lower primary surfaces, a first row of circumferentially spaced apart dose containers at a first radius and a second row of circumferentially spaced apart dose containers at a second radius so that the first and second rows are concentric with respect to a center of the disk, wherein the dose containers have dry powder therein, wherein each dose container terminates at a respective aperture in the upper surface and at a respective aperture in the lower surface, wherein a first flexible sealant resides over the apertures in the upper surface, and a second flexible sealant resides over the apertures in the lower surface; andoperating a piercing mechanism to serially rotate between the first and second rows to pierce the sealants of a dose container in one row, then pierce the sealants of a dose container in the other row.
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