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| 국가/구분 | United States(US) Patent 등록 |
|---|---|
| 국제특허분류(IPC7판) |
|
| 출원번호 | US-0780589 (2013-02-28) |
| 등록번호 | US-8647489 (2014-02-11) |
| 발명자 / 주소 |
|
| 출원인 / 주소 |
|
| 대리인 / 주소 |
|
| 인용정보 | 피인용 횟수 : 0 인용 특허 : 540 |
A sensor system, device, and methods for determining the concentration of an analyte in a sample is described. Gated voltammetric pulse sequences including multiple duty cycles of sequential excitations and relaxations may provide a shorter analysis time and/or improve the accuracy and/or precision
A sensor system, device, and methods for determining the concentration of an analyte in a sample is described. Gated voltammetric pulse sequences including multiple duty cycles of sequential excitations and relaxations may provide a shorter analysis time and/or improve the accuracy and/or precision of the analysis. The disclosed pulse sequences may reduce analysis errors arising from the hematocrit effect, variance in cap-gap volumes, non-steady-state conditions, mediator background, a single set of calibration constants, under-fill, and changes in the active ionizing agent content of the sensor strip.
1. A handheld measuring device, for determining the concentration of an analyte in a sample, where the device is adapted to receive a sensor strip and the device comprises: at least two contacts;at least one display; andelectrical circuitry establishing electrical communication between the at least
1. A handheld measuring device, for determining the concentration of an analyte in a sample, where the device is adapted to receive a sensor strip and the device comprises: at least two contacts;at least one display; andelectrical circuitry establishing electrical communication between the at least two contacts and the at least one display, where the electrical circuitry includes a processor in electrical communication with an electric charger and a computer readable storage medium,where the processor is capable of implementing a pulse sequence from the electric charger to the at least two contacts, where the pulse sequence comprises at least two duty cycles,where each of the duty cycles includes an excitation and a relaxation,where the relaxation is from 0.1 to 3 seconds and includes a current reduction to at least one-half the current flow at the excitation maxima,where the excitation includes a potential varied with time,where the processor is capable of measuring resulting currents at the at least two contacts from at least one of the excitations including the potential varied with time, andwhere the processor is capable of determining the analyte concentration in the sample in response to the at least one of the resulting currents. 2. The device of claim 1, where the processor is capable of applying at least one data treatment selected from the group consisting of semi-integral, semi-derivative, and derivative to the resulting currents to determine the analyte concentration in the sample. 3. The device of claim 1, where the relaxation includes a current flow reduction to at least an order of magnitude less than the current flow at the excitation maxima. 4. The device of claim 1, where the relaxation includes a current reduction to a zero current flow state. 5. The device of claim 1, where the excitation is from 0.1 to 1.5 seconds. 6. The device of claim 1, where the relaxation is from 0.1 to 2 seconds. 7. The device of claim 1, where an excitation/relaxation time ratio of the duty cycles is from 0.3 to 0.2. 8. The device of claim 1, where the pulse sequence implemented by the processor comprises at least three duty cycles within 5 seconds. 9. The device of claim 1, where the processor is further capable of linearly varying the excitation potential at a rate of at least 2 mV/sec. 10. The device of claim 9, where the excitation implemented by the processor is selected from the group consisting of linear, cyclic, acyclic, and combinations thereof. 11. The device of claim 1, where the excitations are acyclic and substantially exclude a reverse oxidation peak or a reverse reduction peak of a measurable species responsive to the concentration of the analyte in the sample. 12. The device of claim 1, where the excitations are acyclic and terminate before initiation of a reverse current peak. 13. The device of claim 1, where the excitations are acyclic and substantially exclude forward and reverse oxidation and reduction peaks of a measurable species responsive to the concentration of the analyte in the sample. 14. The device of claim 1, where the excitations are acyclic and are substantially within a diffusion limited current region of a redox pair. 15. The device of claim 1, where the processor is further capable of determining a plurality of calibration sets from the resulting currents. 16. The device of claim 15, where the processor is capable of determining the analyte concentration in the sample in response to the at least one of the resulting currents by averaging multiple concentration values obtained from the plurality of calibration sets. 17. The device of claim 15, where the processor is further capable of determining the number of duty cycles of the pulse sequence to apply to the sample from the plurality of calibration sets. 18. The method of claim 15, where the processor is further capable of determining a duration of the pulse sequence to apply to the sample in response to the determined analyte concentration in the sample. 19. The device of claim 1, where the processor is further capable of comparing at least one resulting current to a pre-selected value stored in the computer readable storage medium; and determining if a sensor strip containing the sample is under-filled with the sample from the comparison. 20. The device of claim 19, where the processor is further capable of providing a signal to the at least one display signaling to add additional sample to the sensor strip if the sensor strip is under-filled. 21. The device of claim 1, the processor further capable of determining a ratio from forward and reverse scan resulting currents; and determining an active ionizing agent content of a sensor strip, where the ratio was previously correlated to known amounts of the active ionizing agent, and where the known amounts of the active ionizing agent are stored in the computer readable storage medium. 22. The device of claim 21, the processor further capable of altering a calibration slope in response to the active ionizing agent content of the sensor strip. 23. The device of claim 1, where the sample is a liquid comprising a biological fluid. 24. The device of claim 1, where the sensor strip comprises at least first and second sensor strip contacts, the first sensor strip contact in electrical communication with a working electrode and the second sensor strip contact in electrical communication with a counter electrode through conductors, where a first reagent layer is on at least one of the electrodes, the first reagent layer comprising an oxidoreductase and at least one species of a redox pair. 25. The device of claim 24, where the electrodes are on the same substrate. 26. The device of claim 24, where the electrodes are on different substrates. 27. The device of claim 24, where the working electrode includes a diffusion barrier layer. 28. The device of claim 1, where the processor is capable of determining the analyte in the sample with less bias attributable to mediator background than a device that determines the analyte in the sample lacking a processor capable of implementing a pulse sequence including the at least two duty cycles.
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