Solid polymer delivery compositions and methods for use thereof
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-048/00
A61K-039/395
C08F-020/00
A61F-002/02
출원번호
US-0525491
(2006-09-21)
등록번호
US-8652504
(2014-02-18)
발명자
/ 주소
Li, Hong
Turnell, William G.
Yuan, Yumin
Landis, Geoffrey C.
Knoy, Ryan L.
출원인 / 주소
Medivas, LLC
대리인 / 주소
Nixon & Vanderhye P.C.
인용정보
피인용 횟수 :
0인용 특허 :
83
초록▼
The present invention provides an implantable solid polymer delivery composition that can be formulated to release a bioactive agent to an interior body site at a controlled rate over an extended period of time by adjusting the various components of the composition. The controlled delivery of the co
The present invention provides an implantable solid polymer delivery composition that can be formulated to release a bioactive agent to an interior body site at a controlled rate over an extended period of time by adjusting the various components of the composition. The controlled delivery of the composition avoids an initial drug spike, resulting in a smooth delivery profile over time. Polymer layers in the composition can be porous and are both biodegradable in water and body enzymes and biocompatible. Methods of making the implantable solid polymer compositions and methods of delivering a bioactive agent at a controlled rate to an interior body site are also provided.
대표청구항▼
1. A method for making a solid polymer composition for controlled release of a bioactive agent comprising: a) casting or spraying onto a removable solid substrate the following polymer layers: i) a carrier layer comprising a liquid dispersion or solution in a first solvent of at least one bioactive
1. A method for making a solid polymer composition for controlled release of a bioactive agent comprising: a) casting or spraying onto a removable solid substrate the following polymer layers: i) a carrier layer comprising a liquid dispersion or solution in a first solvent of at least one bioactive agent and a biodegradable, biocompatible polymer;ii) a coating layer of a liquid solution in a second solvent of a biodegradable, biocompatible polymer; andiii) a liquid barrier layer intermediate between the carrier layer and the coating layer, wherein the barrier layer is insoluble in the first or second solvent, but dissolves under physiological conditions;b) drying each layer before casting or spraying the next layer thereon,wherein the biodegradable, biocompatible polymer of a) i) comprises at least one or a blend of poly(ester-amide)s (PEAs) having formula (I) or formula (IV); andc) removing the removable solid substrate from the composition prior to use,wherein the PEA of formula (I) is: wherein n ranges from about 5 to about 100;R1 is independently selected from residues of α,ω-bis(4-carboxyphenoxy)(C1-C8)alkane, 3,3′-(alkanedioyldioxy)dicinnamic acid, 4,4′-(alkanedioyldioxy)dicinnamic acid, residues of α,ω-alkylene dicarboxylates of formula (III): (C2-C20)alkylene, (C2-C20)alkenylene and combinations thereof;R5 and R6 are independently selected from (C2-C12)alkylene and (C1-C12)alkenylene;the R3s in individual n monomers are independently selected from hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, (C6-C10)aryl(C1-C6)alkyl and —(CH2)2S(CH3); andR4 is independently selected from (C2-C20)alkylene, (C2-C20)alkenylene, (C2-C8)alkyloxy (C2-C20)alkylene, bicyclic-fragments of 1,4:3,6-dianhydrohexitols of structural formula (II): and combinations thereof; andwherein the PEA of formula (IV) is: wherein n ranges from about 5 to about 150, m ranges about 0.1 to 0.9: p ranges from about 0.9 to 0.1;R1 is independently selected from residues of α,ω-bis(4-carboxyphenoxy)(C1-C8)alkane, 3,3′-(alkanedioyldioxy)dicinnamic acid, 4,4′-(alkanedioyldioxy)dicinnamic acid, residues of α,ω-alkylene dicarboxylates of formula (III), (C2-C20)alkylene, (C2-C20)alkenylene, and combinations thereof;R5 and R6 in Formula (III) are independently selected from (C2-C12)alkylene and (C2-C12)alkenylene;each R2 is independently selected from hydrogen, (C1-C12)alkyl, (C2-C8)alkyloxy(C2-C20) alkyl, (C6-C10)aryl, and a protecting group;the R3s in individual m monomers are independently selected from hydrogen, (C1-C6) alkyl, (C2-C6)alkenyl, (C6-C10)aryl(C1-C6)alkyl and —(CH2)2S(CH3); andR4 is independently selected from (C2-C20)alkylene, (C2-C20)alkenylene, (C2-C8)alkyloxy (C2-C20)alkylene, bicyclic-fragments of 1,4:3,6-dianhydrohexitols of formula (II), and combinations thereof, andR7 is independently selected from (C1-C20) alkyl and (C2-C20 alkenyl. 2. The method of claim 1, wherein the biodegradable, biocompatible polymer of the coating layer of a) ii) comprises at least one or a blend of PEAs having formula (I) or formula (IV). 3. The method of claim 1, wherein the coating layer is free of bioactive agents. 4. The method of claim 1, wherein the polymer of a) i) is the same as the polymer of a) ii). 5. The method of claim 4, wherein the first solvent and the second solvent are the same. 6. The method of claim 1, wherein the casting is electrospinning and the layers of the composition are formed as a mesh of micro fibers. 7. The method of claim 1, wherein each of the polymer layers further comprises a pore-forming substance that results in the composition product having increased porosity. 8. The method of claim 7, wherein the pore-forming substance forms interconnected macroporous scaffolds in the composition product. 9. The method of claim 1, further comprising repeating a) ii) and a) iii) multiple times to form multiple sets of the barrier layer and the coating layer, with the coating layer of each set being exterior to the barrier layer in the composition. 10. The method of claim 9, wherein the multiple sets are applied twice to form two external sides of a sandwich structure, with a coating layer being exterior to each of the two sides and with the carrier layer being at the center of the sandwich structure. 11. The method of claim 1, wherein two to ten sets of the barrier layer and coating layer are formed. 12. The method of claim 1, wherein two to eight sets of the barrier layer and the coating layer are formed. 13. The method of claim 1, wherein the first solvent is ethanol and the liquid polymer used in a) iii) is polyvinyl alcohol. 14. The method of claim 1, wherein R3 is CH2Ph. 15. The method of claim 1, wherein the barrier layer is free of bioactive agents.
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