초록 ▼

Methods and systems for evaluating a pathological condition include acquiring movement information, such as electromyogram (EMG) information, and sleep disordered breathing (SDB) information, and detecting the presence of a pathological condition using both movement and SDB information. Methods may

Methods and systems for evaluating a pathological condition include acquiring movement information, such as electromyogram (EMG) information, and sleep disordered breathing (SDB) information, and detecting the presence of a pathological condition using both movement and SDB information. Methods may involve sensing physiological signals including at least muscle movement signals. Sleep-related disorders are detected using the sensed physiological signals, the sleep-related disorders including at least an involuntary muscle movement disorder and sleep-disordered breathing. Methods and systems also provide for detecting and treating a sleep-related disorder using movement and SDB information. Cardiac, respiratory, nerve stimulation, drug, or a combination of such therapies may be delivered to treat a detected or diagnosed pathological condition.

대표청구항 ▼

1. A system, comprising: a plurality of sensors configured to respectively sense a plurality of physiological signals including at least muscle movement signals comprising electromyogram signals;a detector configured to detect sleep-related disorder events using the sensed physiological signals, the

1. A system, comprising: a plurality of sensors configured to respectively sense a plurality of physiological signals including at least muscle movement signals comprising electromyogram signals;a detector configured to detect sleep-related disorder events using the sensed physiological signals, the sleep-related disorder events comprising involuntary muscle movement events of non-respiratory muscles and sleep-disordered breathing events, the detection of the sleep-disordered breathing events and the involuntary muscle movement events based at least in part on the electromyogram signals; anda processor configured to calculate a composite sleep disorder index, the composite sleep disorder index quantifying combined effect of the involuntary muscle movement events and the sleep-disordered breathing events, wherein at least one of calculating and detecting is configured to be implemented at least in part patient-internally. 2. The system of claim 1, further comprising communications circuitry configured to communicate one or both of the plurality of physiological signals and information associated with the detected sleep-related disorder events to a patient-external processing system. 3. The system of claim 1, further comprising communications circuitry configured to communicate one or more of the plurality of physiological signals, information associated with the detected sleep-related disorder events, and the composite sleep disorder index to an implantable medical device. 4. The system of claim 1, further comprising at least one of a controller configured to control therapy to treat a condition associated with one or more of the detected sleep-related disorder events based on the sleep movement disorder index and a therapy delivery unit configured to deliver the therapy to treat the condition associated with one or more of the detected sleep-related disorder events based on the composite sleep disorder index. 5. The system of claim 1, wherein the processor is configured to calculate the composite sleep disorder index including calculating an apnea/hypopnea index and a movement disorder index, the apnea/hypopnea index representative of an amount of apnea and hypopnea events relative to time and the movement disorder index representative of an amount of the involuntary muscle movement events relative to time. 6. The system of claim 1, wherein the sleep-disordered breathing events comprise one or more of sleep apnea, hypopnea, and Cheyne-Stokes respiration. 7. The system of claim 1, wherein the involuntary muscle movement events comprise one or more of bruxism, periodic limb movement disorder, and restless leg syndrome. 8. The system of claim 1, wherein the plurality of sensors includes a transthoracic impendence sensor. 9. The system of claim 1, wherein the processor is further configured to determine one or more sleep stages based at least in part on one or more of the physiological signals. 10. The system of claim 1, wherein the processor is further configured to determine a patient's arousal from sleep events. 11. The system of claim 1, further comprising an implantable device configured to deliver a therapy in response to the composite sleep disorder index. 12. The system of claim 1, further comprising a positive airway pressure device configured to deliver a respiratory therapy in response to the composite sleep disorder index. 13. The system of claim 1, further comprising a drug delivery device configured to treat the involuntary muscle movement events. 14. The system of claim 1, further comprising a transcutaneous electric nerve stimulation therapy device configured to treat the involuntary muscle movement events. 15. A system, comprising: a plurality of sensors configured to respectively sense a plurality of physiological signals including at least one muscle movement signal;one or more electrical components structured to: detect sleep-related disorder events using the sensed physiological signals, the sleep-related disorder events including involuntary muscle movement events of non-respiratory muscles and sleep-disordered breathing events; anddetermine a composite sleep disorder index, the composite sleep disorder index quantifying combined effect of the involuntary muscle movement events and the sleep-disordered breathing events. 16. The system of claim 15, wherein the one or more electrical components includes two or more electrical components, with at least one of the two or more electrical components is configured to be implanted patient-internally. 17. The system of claim 16, wherein at least one of the two or more electrical components is part of a patient-external processing system. 18. The system of claim 15, wherein the sleep-disordered breathing events include one or more of sleep apnea, hypopnea, and Cheyne-Stokes respiration. 19. The system of claim 15, wherein the involuntary muscle movement events include one or more of bruxism, periodic limb movement disorder, and restless leg syndrome. 20. A system, comprising: a plurality of sensors configured to respectively sense a plurality of physiological signals including at least one muscle movement signal that is an electromyogram signal;one or more electrical components structured to: detect sleep-related disorder events using the sensed physiological signals, the sleep-related disorder events including involuntary muscle movement events of non-respiratory muscles and sleep-disordered breathing events, the detection of the sleep-disordered breathing events and/or the involuntary muscle movement events based at least in part on the electromyogram signal; anddetermine a composite sleep disorder index, the composite sleep disorder index quantifying combined effect of the involuntary muscle movement events and the sleep-disordered breathing events, wherein at least one of determining and detecting is configured to be implemented at least in part patient-internally.